A5101495343- RNA modifications and cancer
- Inflammasome and immune disorders
- RNA Research and Splicing
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Parathyroid Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Chronic Kidney Disease and Diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Adenosine and Purinergic Signaling
- Medicinal Plants and Bioactive Compounds
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Nanoplatforms for cancer theranostics
- BRCA gene mutations in cancer
- Cardiac electrophysiology and arrhythmias
- Advanced Breast Cancer Therapies
China Medical University
2014-2025
Harbin Medical University
2024-2025
Sheng Jing Hospital
2020-2025
Yale University
2020-2025
Xi'an Peihua University
2018-2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Hudson Institute
2020
Shanxi Medical University
2019
Nanjing University
2016-2019
Traumatic brain injury (TBI) is a critical public health and socioeconomic problem throughout the world. Inflammation-induced secondary one of vital pathogenic parameters TBI. Molecular signaling cascades pyroptosis, specific type cellular necrosis, are key drivers TBI-induced inflammation.In this study, mice with genetically ablated caspase-1 (caspase-1-/-) were subjected to controlled cortical impact in vivo, primary neuron deficient through siRNA knockdown pharmacologic inhibition was...
As one of the most common causes mortality and disability, traumatic brain injury (TBI) is a huge psychological economic burden to patients, families, societies worldwide. Neuroinflammation reduction may be favorable option alleviate secondary injuries ameliorate outcome TBI. The nucleotide-binding oligomerization domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome, has been shown involved in NIMA-related kinase 7 (NEK7) verified as an essential mediator NLRP3...
Diabetic retinopathy (DR), an obstacle of the visual microvascular system, is a serious complication diabetic patients. Paraoxonase 1 (PON1) has been extensively evaluated as genetic candidate for complications, and PON1 associated with DR. In this study, biological functions its related proteins were determined via gene ontology (GO) enrichment analysis; we demonstrated that treatment resveratrol alleviated retinal inflammatory activities to evaluate protective effects on streptozotocin...
Several EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib (Gef), have been used effective clinical therapies for patients with non-small cell lung cancer (NSCLC). However, due to acquired resistance, the efficacy of Gef treatment is severely blocked. Our preliminary study found that epigallocatechin gallate (EGCG) in combination could work synergistically increase sensitivity NSCLC, but mechanisms responsible this not completely defined.In our present study, we devoted investigate...
Diosmetin was found to exert protective effect on renal and myocardial ischemia-reperfusion (IR) injury. This study aimed investigate the role of diosmetin in cerebral IR (CIR) PC12 neurons were exposed oxygen-glucose deprivation/reoxygenation (OGD/R) establish CIR injury model vitro then incubated with diosmetin, we that alleviated OGD/R-induced viability inhibition, LDH release, apoptosis, oxidative stress cells. Then our results showed downregulated kelch like ECH-associated protein 1...
Autophagy plays an important role in cellular homeostasis. Epigallocatechin gallate (EGCG), a polyphenol derived from green tea, has been shown to elicit vascular protective effects. Our study aimed investigate the effect of EGCG endothelial injury model induced by hydrogen peroxide (H2O2) and reveal possible mechanisms.Human cells (HUVECs) were pretreatment with different concentration EGCG, then exposed H2O2. Cell viability was measured MTS assay. Apoptosis evaluated TUNEL staining...
Fat mass and obesity-associated protein (FTO) regulates critical pathways in various diseases, including malignant tumours. However, the functional link between FTO its target genes epithelial ovarian cancer (EOC) development remains to be elucidated. In this study, biological functions of were verified vitro vivo. The m6A modification binding sites SNAI1 mRNA confirmed by RNA immunoprecipitation (MeRIP) RIP experiments. actinomycin D assay was used test stability RNA. We found that...
Recurrent tumors that are resistant to conventional chemotherapy a major challenge of ovarian cancer treatment. A better understanding the underlying molecular mechanisms chemoresistance is critical for developing more effective targeted therapies cancer. In this study, we analyzed transcriptomic profiles thirteen pairs matching primary and recurrent cancers identify genes were upregulated in tumors. Among these genes, identified sortilin-related receptor 1 (SORL1) its role promoting...
Sinomenine (SINO), which is used clinically to treat rheumatoid arthritis and neuralgia, derived from the root stems of <em>Sinomenium acutum</em>. SINO has been reported exert analgesic, sedative anti‑inflammatory effects, provides a protective role against shock organ damage. Studies have suggested that primarily exerts it function by inhibiting NF‑κB signaling. There also evidence indicate may regulate inflammation Nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) The present study aimed...
Abstract Methytransferase-like proteins 9 (METTL9) has been characterized as an oncogene in several cancers, however, its role hepatocellular carcinoma (HCC) remains unknown. Here, we investigated the function and molecular mechanism of METTL9 HCC. We showed that expression was elevated HCC, high associated with poor survival outcomes. Knockdown observed a significant inhibition HCC cell viability, migration, invasion both vitro vivo. By contrast, overexpression cells obtained stronger...
BRCA mutations are the main known hereditary factor for breast cancer. Notably, poly (ADP-ribose) polymerase 1 (PARP1) expression status plays a critical role in cancer progression and clinical development of PARP1 inhibitors to treat BRCA-mutated has advanced rapidly. However, dynamic crosstalk between BRCA1 remains largely unknown. Here, we showed that: (i) inactivation events (mutation, promoter methylation, or knockdown) were accompanied by increased nicotinamide adenine dinucleotide...
ITFG2, as an immune-modulatory intracellular protein that modulate the fate of B cells and negatively regulates mTORC1 signaling. ITFG2 is highly expressed in heart, but its pathophysiological function heart disease unclear. In this study, we found MI mice, overexpression via AAV9 vector significantly reduced infarct size ameliorated cardiac function. Knockdown endogenous by shRNA partially aggravated ischemia-induced dysfunction. cardiac-specific transgenic (TG) myocardial infarction was...
Antiaging protein Klotho exhibits impressive properties of anti-inflammation, however is declined early after intervertebral disc injury, making restoration an attractive strategy treating inflammatory disorders. Here, we have found that enriched in nucleus pulposus (NP) cells and overexpression attenuates H 2 O -induced acute inflammation essentially via suppressing Toll-like receptor 4 (TLR4). The proinflammatory NF- κ B signaling cytokine expressions paralleled with repression TLR4...
Neurological dysfunction provoked by traumatic brain injury (TBI) makes a huge impact on individual learning ability, memory level, social participation, and quality of life. Pyroptosis, the caspase-1-dependent cell death, which is associated with release numerous pro-inflammatory factors, plays major role in pathological process after TBI. Inhibition pyroptosis has been shown to be an attractive strategy for treatment various neurological disorders. Here, we found that Rhein, anthraquinone...
Inflammation is thought to play an important role in the pathophysiology of ischaemic stroke, which a main cause disability and morbidity worldwide. Inhibition NOD‑like receptor protein 1 (NLRP1) inflammasome has been reported alleviate inflammatory response cell animal models. Ligustroflavone (LIG) compound derived from <em>Ligustrum lucidum</em>, shows anti‑inflammatory activity may beneficial number neurological diseases. To date, potential for LIG act through NLRP1 as treatment ischemic...
Objectives:The epidemiological and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) have been researched.However, the prevalence repositivity by real-time PCR for severe acute respiratory syndrome 2 (SARS-CoV-2) remains unclear.Methods: A retrospective study was conducted involving 599 discharged COVID-19 in a single medical centre.The features during their hospitalization 14-day postdischarge quarantine were collected.Results: total 122 (20.4%) out retested...