A5101683837- Wheat and Barley Genetics and Pathology
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Yeasts and Rust Fungi Studies
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Sarcoidosis and Beryllium Toxicity Research
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Inhalation and Respiratory Drug Delivery
- Genetic Syndromes and Imprinting
- RNA and protein synthesis mechanisms
- Renin-Angiotensin System Studies
- Cytokine Signaling Pathways and Interactions
- Genetic and phenotypic traits in livestock
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- Bone and Joint Diseases
- Genomics and Phylogenetic Studies
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Plant Pathogens and Fungal Diseases
Sun Yat-sen University Cancer Center
2023-2024
Sun Yat-sen University
2023-2024
Agricultural Research Service
2019-2022
Chinese Academy of Agricultural Sciences
2022
Institute of Plant Protection
2022
Shanghai Sixth People's Hospital
2021
United States Department of Agriculture
2019
Southern Medical University
2012-2014
Nanfang Hospital
2014
Abstract Methytransferase-like proteins 9 (METTL9) has been characterized as an oncogene in several cancers, however, its role hepatocellular carcinoma (HCC) remains unknown. Here, we investigated the function and molecular mechanism of METTL9 HCC. We showed that expression was elevated HCC, high associated with poor survival outcomes. Knockdown observed a significant inhibition HCC cell viability, migration, invasion both vitro vivo. By contrast, overexpression cells obtained stronger...
Sustained renin-angiotensin system (RAS) activation in asthmatic patients plays a crucial role airway hyperresponsiveness and airflow limitation. Angiotensin II (Ang II), as key peptide of RAS, contributes to the contraction human smooth muscle by activating RhoA/Rho-associated coiled-coil containing protein kinase 2 (ROCK2) signaling pathway. Angiotensin-(1-7) [Ang-(1-7)], is component angiotensin I converting enzyme (ACE2)-Ang-(1-7)-Mas axis which counteracts detrimental effects ACE- Ang...
Powdery mildew is a key airborne foliar disease of barley in southeastern and southwestern China. Barley varieties usually partially or wholly lose resistance to the pathogen Blumeria graminis (DC.) f. sp. hordei 3 5 years after release due frequent acquirements new virulences population. However, no B. virulence detection has been carried out recent decade and, thus, information available on present components major pathotypes epidemic regions. Twenty-one near-isogenic lines Pallas were...
To address the increased energy demand, tumor cells undergo metabolic reprogramming, including oxidative phosphorylation (OXPHOS) and aerobic glycolysis. This study investigates role of Kruppel-like factor 4 (KLF4), a transcription factor, as suppressor in hepatocellular carcinoma (HCC) by regulating ATP synthesis. Immunohistochemistry was performed to assess KLF4 expression HCC tissues. Functional assays, such CCK-8, EdU, colony formation, well vivo subcutaneous formation liver orthotopic...
Verticillium wilt (VW) of alfalfa is a devastating disease that causes forage yield reductions up to 50% in the northern United States and Canada. The most effective method for controlling through development use resistant varieties. To identify quantitative trait loci (QTL) VW resistance alfalfa, we used full-sib population segregating resistance. High-density linkage maps both susceptible parents were constructed using single-dose alleles single-nucleotide polymorphism markers generated by...
Verticillium wilt (VW) is a soil-borne fungus disease in wide range of plant species including alfalfa and caused yield loss up to 50% less than 3 years due the rapid spreading pathogen soil (Vandemark et al., 2006). However, genes responsible for resistance against V. alfalfae still unknown. In tomato, well-studied gene locus VW known as Ve (Fradin 2011). orthologues M. truncatula sativa share low sequence identity with tomato Ve1 were not involved response (Toueni 2016), indicating...
The aim of this study was to investigate the correlation between -112G/A polymorphism uteroglobulin-related protein 1 (UGRP1) gene and asthma risk using meta-analysis. PubMed, BIOSIS Previews EBSCOhost were searched, data extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) used assess strength associations. Statistical analysis performed Review Manager 5.2 STATA 11.0 software. Six studies, involving 816 cases 1,165 controls, included...