A5078459356- Anesthesia and Neurotoxicity Research
- Bone and Dental Protein Studies
- dental development and anomalies
- Intensive Care Unit Cognitive Disorders
- Vagus Nerve Stimulation Research
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Airway Management and Intubation Techniques
- Hip disorders and treatments
- Oral and Maxillofacial Pathology
- Bone health and treatments
- Anesthesia and Sedative Agents
- Genetics and Neurodevelopmental Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Peroxisome Proliferator-Activated Receptors
- Restraint-Related Deaths
- Cancer Research and Treatments
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
Shenzhen University
2022-2024
Hainan General Hospital
2022-2023
Hainan Medical University
2021-2023
Wenzhou Medical University
2021
Hubei Provincial Women and Children's Hospital
2013-2021
Children's Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
Southern Medical University
2012-2020
Hainan Maternal and Child Health Hospital
2020
University of Benin
2020
Traumatic brain injury (TBI) is one of the main concerns worldwide as there still no comprehensive therapeutic intervention. Astrocytic water channel aquaporin-4 (AQP-4) system closely related to edema, transport at blood-brain barrier (BBB) and astrocyte function in central nervous (CNS). Minocycline, a broad-spectrum semisynthetic tetracycline antibiotic, has shown anti-inflammation, anti-apoptotic, vascular protection neuroprotective effects on TBI models. Here, we tried further explore...
Dentin dysplasia type I (DDI) is an autosomal-dominant genetic disorder resulting from dentin defects. The molecular basis of DDI remains unclear. exhibits unique characteristics with phenotypes featuring obliteration pulp chambers and diminutive root, thus providing a useful model for understanding the genetics tooth formation. Using large Chinese family 14 patients, we mapped gene locus responsible to 3p26.1–3p24.3 further identified missense mutation, c.353C>A (p.P118Q) in SSUH2 on...
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") the second most abundant enamel matrix protein known to have key role in amelogenesis. Amelogenesis imperfecta (AI [MIM: 104500]) refers genetically phenotypically heterogeneous group conditions characterized by inherited developmental defects. The hereditary dentin disorders comprise...
<h3>Background</h3> Dentin dysplasia I (DDI) is a genetically heterogeneous autosomal-dominant disorder characterised by rootless teeth with abnormal pulpal morphology, the aetiology of which presents as heterogeneous. <h3>Methods and results</h3> Using cohort large Chinese family 10 patients DDI, we mapped to 9.63 Mb candidate region for DDI on chromosome 18q21.2–q21.33. We then identified mutation IVS7+46C>G resulted in novel donor splice site intron 7 <i>VPS4B</i> gene co-segregation...
The overexpression of peroxiredoxins (prxs) has been shown to be associated with the development, progression and drug resistance cancer. However, role prxs in ovarian cancer is unknown. present study aimed investigate effect mechanism downregulation PRDX3 on cisplatin‑induced cell apoptosis. expression was examined by immunohistochemistry. apoptosis silencing determined proliferation colony formation assays examination tumor growth nude mice. To further behind PRDX3, anti‑apoptotic proteins...
Abstract Objective The aim of this prospective randomized double-blind study is to evaluate whether oral dexmedetomidine (DEX) premedication could increase sedation in order reduce preoperative anxiety and inhibit stress response during general anesthesia tracheal intubation. Materials A total 100 ASA I II adult patients undergoing elective neurosurgery were randomly divided into the control group (C group, n = 50) DEX (DEX 50). Patients administrated 4 μg/kg orally pre-anesthesia 120 min....
Suspension laryngoscopy is commonly used in operative laryngology. Although it efficient and minimally invasive most cases, can lead to postoperative sore throat (POST) cough. Because of intensive stimulation by the rigid metal suspension laryngoscope, procedures must be implemented under general anesthesia. Together, these factors increase possibility complications. Blocking internal branch superior laryngeal nerve (SLN) useful inhibiting endotracheal intubation stress response. Thus, we...
Mutations in proline-rich transmembrane protein 2 (PRRT2) are a cause of paroxysmal kinesigenic dyskinesia (PKD). In this study, we investigated the PRRT2 gene mutation Chinese Han family with PKD and study pathogenesis gene. Peripheral venous blood was taken from members. Sanger sequencing used for novel sequencing. For analyzed by bioinformatics, real-time PCR, subcellular localization Western blot. The showed mutation, c.186-187delGC, deletion exon gene, frameshift generated truncated...
Background: Our study sought to obtain data which assess the diagnostic value of transvaginal three-dimensional ultrasound (3D-US) combined with color Doppler (US) for early cesarean scar pregnancy (CSP). Methods: All participants were randomly divided into a Control group diagnosed using 3D-US and Combination US. The preoperative US results compared postoperative pathological results. coincidence rate, sensitivity, specificity these two examination methods compared, their different types...
The purpose of this study was to determine whether interleukin-10 (IL-10) promoter polymorphisms are associated with leprosy or their subtypes in ethnic groups from southwest China. Genotyping using TaqMan® SNP Master Mix and ABI 7500 real-time PCR system performed for IL-10 T3575A, G2849A, C2763A, A1082G, C819T, C592A 189 healthy controls (40 ± 18 years) 193 patients (46 [multibacillary, N = 131; paucibacillary (PB), 62]. allelic frequencies -2763C (97.9 vs 94.0%, P 0.0074) -1082A (92.8...
The aim of this study was to observe the therapeutic effect curcumin chitosan microspheres (CCM) on ulcerative colitis (UC) in rats. Rat UC model prepared by 2,4,6-trinitrobenzenesulfonic acid (TNBS) method. All animals were divided into blank control group (BCG), (MCG), mesalazine enteric-coated tablets (MECT), microsphere low (CCML), medium (CCMM) and high dose groups (CCMH). Starting from third day after establishment, rats intra-gastrically administered for 10 days. On 14th experiment,...
Objective: To report a family diagnosed with Allan-Herndon-Dudley syndrome (AHDS) due to SLC16A2 gene mutation and summarize the phenotypes, genotypes, diagnosis, treatment, prognosis. Methods: The clinical features of AHDS in Xiangya Hospital Central South University November 2017 were analyzed. Related literature was searched at Online Mendelian Inheritance Man (OMIM), PubMed, CNKI Wanfang database (from establishment databases June 2018) by using "Allan-Herndon-Dudley syndrome" , "AHDS"...
Background Alcoholic osteonecrosis of the femoral head (ONFH) is a multifaceted illness that seriously disturbs patients’ quality life. The role lncRNAs in alcoholic ONFH has attracted widespread attention recent years. This study mainly explored whether MIR31HG polymorphism affects risk ONFH. Methods There were 733 males (308 alcohol-induced patients and 425 healthy controls). Seven single nucleotide polymorphisms from genotyped using Agena MassARRAY platform. Odds ratio (OR) 95% confidence...
Ciprofol is a novel anesthetic agent, its efficacy and safety had been verified clinical implementation has expanded. However, the knowledge about ciprofol in children meager. The aim of study to evaluate effectiveness general anesthesia undergoing adenoidectomy adenotonsillectomy, compared with propofol.
Polycystic kidney disease (PKD) and Alport syndrome (AS) are serious inherited disorders associated with renal disease, thalassemia is a hereditary blood high prevalence in south China. Here, we report an exceptional PKD coincidence of minor AS (diagnosed genetically) large Chinese family. Whole genome next-generation sequencing (NGS) was performed on the proband, all family members underwent clinical evaluation. Sanger used to validate mutations distinguished by NGS. The pathogenic...
Objective General anesthesia can disturb the hormone levels in surgical patients. Hormone deficiency is one of major symptoms craniopharyngioma (CP) pediatric The aim this prospective randomized controlled clinical study to evaluate whether propofol and sevoflurane influence perioperative these patients determine which technique causes less impact on levels. Materials Sixty-four ASA I II with CP undergoing elective neurosurgery were randomly divided into group (S group, n = 32) (P 32)....