A5100452666- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Virology and Viral Diseases
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Family Support in Illness
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Axon Guidance and Neuronal Signaling
- Sleep and related disorders
- Family and Disability Support Research
- Psychosocial Factors Impacting Youth
- Nuclear Receptors and Signaling
- Electrolyte and hormonal disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience and Neuropharmacology Research
- Wnt/β-catenin signaling in development and cancer
- Vitamin D Research Studies
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Hormonal Regulation and Hypertension
Peking University Sixth Hospital
2018-2024
Zhejiang University
2024
Peking University
2018-2024
Capital University
2024
Capital Medical University
2021-2024
Central China Normal University
2022
Beijing Anding Hospital
2021
Leibniz Institute for Neurobiology
2012
Otto-von-Guericke University Magdeburg
2012
Abstract Chronic stress may disrupt the normal neurodevelopmental trajectory of adolescent brain (especially prefrontal cortex) and contribute to pathophysiology stress-related mental illnesses, but underlying molecular mechanisms remain unclear. Here, we investigated how synaptic cell adhesion molecules (e.g., nectin3) are involved in effects chronic on mouse medial cortex (mPFC). Male C57BL/6N mice were subjected social instability from postnatal days 29 77. One week later, exposed...
Major depressive disorder is a major psychiatric and leading cause of disability around the world. Females have about twice as high an incidence depression males. However, preclinical animal models seldom investigated molecular alterations associated with higher risk in females. In this study, adopting early-life stress (ELS) paradigm limited bedding nesting material, we found that ELS induced depression-like behaviors only adult female mice, evaluated by sucrose preference tail suspension...
With the growing use of second-generation antipsychotics for treatment a spectrum psychiatric illnesses in pregnancy, concerns have been raised about long-term impact these medications on offspring neurodevelopment. However, preclinical and clinical evidence lasting effects prenatal antipsychotic exposure is still sparse.Risperidone, widely used antipsychotic, haloperidol, representative first-generation were administered to pregnant C57BL/6N mice from embryonic day 6 16. Behavioral tests,...
Cognitive impairment, a core symptom of psychiatric disorders, is frequently observed in adolescents exposed to early-life stress (ES). However, the underlying neural mechanisms are unclear, and therapeutic efficacy limited. Targeting parvalbumin-expressing interneurons (PVIs) medial prefrontal cortex (mPFC), we report that ES reduces mPFC PVI activity, which causally mediated ES-induced cognitive deficits adolescent male mice through chemogenetic optogenetic experiments. To understand...
Exposure to adverse experiences in early life may profoundly reshape the neurodevelopmental trajectories of brain and lead long-lasting behavioral neural alterations. One deleterious effect early-life stress that manifests later is sleep disturbance, but this has not been examined aged mice underlying mechanisms remain unknown. Considering important role nucleus accumbens (NAc) sleep-wake regulation, study aimed assess effects on behaviors potential involvement NAc stress-induced...
The early postnatal stage is a critical period of hippocampal neurodevelopment and also high vulnerability to adverse life experiences. Recent evidence suggests that nectin-3, cell adhesion molecule, mediates memory dysfunction dendritic alterations in the adult hippocampus induced by stress. But it unknown whether nectin-3 reduction alone sufficient alter structure function adulthood. Here, we down regulated expression its heterophilic partner nectin-1, respectively, from injecting...
<title>Abstract</title> Cognitive impairment, one core symptom of psychiatric disorders, is frequently observed in adolescents exposed to early-life stress (ES). However, the underlying neural mechanisms are unclear and therapeutic efficacy limited. Targeting at parvalbumin-expressing interneurons (PVIs) medial prefrontal cortex (mPFC), we report that mPFC PVI activity was reduced by ES causally mediated ES-induced cognitive deficits adolescent mice through chemogenetic or optogenetic...
Autism is a complex neurodevelopmental disorder with high heritability. Zinc finger protein 804A (ZNF804A) was suggested to play important roles in neurodevelopment. Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 ZNF804A strongly associated schizophrenia and might influence social interaction. Only one study explored the significance of polymorphisms autism, which discovered rs7603001 nominally autism. Moreover, no previous investigated association between...
Parental support plays a very important role in students" development from the aspects of academic achievement, cognitive style, wellbeing, etc. In fact, parental is long-lasting strength for all students through different learning stages. However, several studies have examined impact on primary and secondary school students, but less known about college students. The phase embedded developmental stage emerging adulthood. Due to changing nature adulthood, need adapt new environment learn be...