A5103326266- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Effects and risks of endocrine disrupting chemicals
- Cancer Treatment and Pharmacology
- Tea Polyphenols and Effects
- Immune cells in cancer
- Herbal Medicine Research Studies
- Cell death mechanisms and regulation
- Fatty Acid Research and Health
- Cardiovascular Health and Risk Factors
- Ectopic Pregnancy Diagnosis and Management
- Heat shock proteins research
- Adipose Tissue and Metabolism
- Pluripotent Stem Cells Research
- Pregnancy-related medical research
- Pregnancy and Medication Impact
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Inflammation biomarkers and pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Uterine Myomas and Treatments
- Microscopic Colitis
- Redox biology and oxidative stress
- RNA modifications and cancer
Wenzhou Medical University
2021-2025
Fudan University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2021-2025
Second Military Medical University
2019-2024
Huazhong University of Science and Technology
2018-2021
Xinxiang Medical University
2017
Henan Psychiatric Hospital
2017
First Affiliated Hospital of Zhengzhou University
2017
McLean Hospital
2017
Harvard University
2017
Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. Developing efficient strategies reverse MDR remains a challenge. Surfactin (SUR), cyclic lipopeptide biosurfactant, has been found display anticancer activity.In this paper, SUR was assembled by solvent-emulsion method load drug doxorubicin (DOX). The cytotoxicity DOX-loaded nanoparticles (DOX@SUR) against DOX-resistant human breast MCF-7/ADR measured MTT assay. cellular uptake and intracellular...
Background and Purpose Dihydro‐resveratrol (DHR), a polyphenol derivative, that has been demonstrated to suppress inflammation‐mediated injury. However, it is still unknown whether anti‐neuroinflammatory neuroprotective effects, therapeutic action in Alzheimer's disease (AD). Experimental approach The anti‐inflammatory anti‐Alzheimer's actions of dihydro‐resveratrol were investigated using lipopolysaccharide (LPS) AD mice models, primary microglial cells. changes behaviour detected by the...
The overexpression of peroxiredoxins (prxs) has been shown to be associated with the development, progression and drug resistance cancer. However, role prxs in ovarian cancer is unknown. present study aimed investigate effect mechanism downregulation PRDX3 on cisplatin‑induced cell apoptosis. expression was examined by immunohistochemistry. apoptosis silencing determined proliferation colony formation assays examination tumor growth nude mice. To further behind PRDX3, anti‑apoptotic proteins...
In recent decades, epidemiological, clinical, and experimental studies have demonstrated that a diet with antioxidant or anti-inflammatory function plays central role in the prevention of atherosclerosis (AS). The purpose this study was to explore effects Cannabis seed oil (CO) administration on vitro capacity as well blood lipid profiles, peroxidation, inflammatory response, endothelial cell integrity. Female ApoE–/– mice were fed high-cholesterol administrated CO phosphate-buffered saline...
Angelica dahurica is a famous functional food and herb. To guarantee quality of A. dahurica, strategy "Q-markers targeted screening" was successfully developed by sufficient extraction compounds the screening qualitative quantitative markers calculated through chemometric methods based fingerprints. Accelerated solvent selected due to its prominent advantages exhibiting maximum yields varieties especially excellent reproducibility (RSD < 1). After extraction, fingerprints dahuricae samples...
In recent years, carbon nanotubes have emerged as a widely used nanomaterial, but their human exposure has become significant concern. our former study, we reported that pulmonary of multiwalled (MWCNTs) promoted tumor metastasis breast cancer; macrophages were key effectors MWCNTs and contributed to the metastasis-promoting procedure in cancer, underlying molecular mechanisms remain be explored. As follow-up herein demonstrated MWCNT cancer cells macrophage coculture systems both vitro...
Tolypocladium sinense is a new asexual strain isolated from natural Cordyceps sinensis. The mycelium produced by its fermentation culture has similar chemical components and pharmacological effects to C. T. soft capsule primarily prepared mycelium, which mainly used for the treatment of body damage induced low-dose ionizing radiation. However, potential toxicity remains unclear. This study was designed assess toxicological characteristics capsules through acute 28-day repeated dose studies....
Objective To study risk factors and pregnancy outcome in patients with preterm premature rupture of membrane (PPROM). Methods From June 2012 to November 2014, a total 100 cases PPROM the Fifth People's Hospital Jingzhou, Hubei Province were recruited as group. Inclusion standards group: diagnosis met Obstetrics Gynecology (2 edition) diagnostic criteria for PPROM. Exclusion ①Pregnancy who abused drug during pregnancy. ②Pregnancy complicated obstetric complications, severe internal...
Objective Analyse about the effect, application and contraindication of GnRH-a agonist therapy before laparoscopic hysteromyomectomy. Methods A retrospective study hysteromyomectomy leiomyoma is longer than 5 cm. Of them 28 cases given GnRH-a(investigation group),36 without any disposal(comparison group), compare operation time, bleeding quantity syndrome 2 groups. Results ①In investigation group, every case includes 1 〜2 leiomyoma, aggregately 32 was excised. Without drug...