A5101656842- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Mesoporous Materials and Catalysis
- Biosensors and Analytical Detection
- Graphene and Nanomaterials Applications
- Supramolecular Self-Assembly in Materials
- Supercapacitor Materials and Fabrication
- Insect Pest Control Strategies
- Microbial Metabolic Engineering and Bioproduction
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Heat Transfer Mechanisms
- Antimicrobial Peptides and Activities
- Agricultural pest management studies
- Nanocluster Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Heat Transfer and Optimization
- Inorganic Chemistry and Materials
- Biofuel production and bioconversion
- Anaerobic Digestion and Biogas Production
- Nanofluid Flow and Heat Transfer
- Metal-Organic Frameworks: Synthesis and Applications
- Photochromic and Fluorescence Chemistry
Huazhong University of Science and Technology
2014-2019
Xinjiang Institute of Materia Medica
2018
Union Hospital
2017
Lasbela University of Agriculture Water and Marine Science
2016
Bharathiar University
2007
Developing biomimetic nanoparticles without loss of the integrity proteins remains a major challenge in cancer chemotherapy. Here, we develop biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon (PSiNPs) as drug carrier for targeted Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis endocytosed DOX-loaded from tumor cells, exhibit enhanced accumulation, extravasation blood vessels and penetration into deep parenchyma following intravenous...
Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The nanovalves tightly close the pores of to control premature cargo release under physiological conditions but respond lysozyme and acidic media trapped cargo.
We demonstrate an ultrasensitive microRNA detection method based on extremely simple probe with only fluorogens but without quencher groups. It avoids complex and difficult steps to accurately design the relative distance between groups in probes. Furthermore, assay could accomplish various limits by tuning reaction temperature due different activity of exonuclease III corresponding diverse temperature. Specifically, 1 pM miR-21 can be detected 40 min at 37 °C, 10 aM (about 300 molecules 50...
Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. Developing efficient strategies reverse MDR remains a challenge. Surfactin (SUR), cyclic lipopeptide biosurfactant, has been found display anticancer activity.In this paper, SUR was assembled by solvent-emulsion method load drug doxorubicin (DOX). The cytotoxicity DOX-loaded nanoparticles (DOX@SUR) against DOX-resistant human breast MCF-7/ADR measured MTT assay. cellular uptake and intracellular...
Herein, we design novel cellulose conjugated mesoporous silica nanoparticle (CLS-MSP) based nanotherapeutics for stimuli responsive intracellular doxorubicin (DOX) delivery. DOX molecules are entrapped in pores of the fabricated nanoparticles (MSPs) while is used as an encapsulating material through esterification on outlet MSPs to avoid premature release under physiological conditions. In vitro studies, successfully achieved from loaded (DOX/CLS-MSPs) by pH and cellulase triggers....
Layered double hydroxides (LDHs) have attracted particular attention as drug delivery carriers due to their variable chemical composition, excellent biocompatibility, high anion exchange capacity and controlled release. However, capability only meets the requirement for encapsulating drugs with negative charge in aqueous media. Encapsulation of positive into LDHs still remains a big challenge. Herein, we report facile strategy obtain highly dispersible doxorubicin-loaded MgAl-LDH nanohybrids...
Nanotechnology-based drug delivery systems exhibit promising therapeutic efficacy in cancer chemotherapy. However, ideal nano carriers are supposed to be sufficiently internalized into cells and then release cargoes response certain intracellular stimuli, which has never been an easy task achieve.This study is design mesoporous silica nanoparticles (MSNs)-based pH-responsive system that effectively lysosomal/endosomal acidified environment.We synthesized MSNs by sol-gel method. Doxorubicin...
We combine the telomerase extension reaction and microRNA (miRNA)-induced rolling circle amplification, followed by graphene oxide (GO) nicking enzyme-assisted signal amplification as a method to analyze miRNA-21 in urine samples with following merits. First, it is binary assay can simultaneously output double signals that correspond quantities of miRNA, respectively. Second, activity enhanced using DNA molecular beacon probe inhibit formation G-quadruplex. Third, background noise decreased...
Disruptive variation in intracellular pH and its fluctuations lysosomes have a close relationship with the more acidic lysosome lumen of cancer cells (pH 4.5-5.5). Traditional lysosome-targeted probes, such as LysoTracker Green DND-26 (LTG) Red DND-99 (LTR), can fluoresce when weak base units probes are removed after donating protons under photoinduced electron-transfer (PET) effect. However they only be used at low concentration to avoid aggregation-caused quenching (ACQ) effect also easily...
Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because controlling functions, properties and stability trapped molecules. Although there are few reports on protein/MOFs composites their applications, none DNA/MOFs composite is reported, as far we know. Here, report a new material which self-assembled from 3D DNA (guest) pre-synthesized MOFs (host) by electrostatic interactions hydrophilic well-dispersed fashion. Its biophysical...
We report a simple colorimetric method using gold nanoparticles as signal generators for the real-time detection of product strand displacement cascade.
Natural convection heat transfer in a square cavity induced by heated plate is studied numerically. Top and bottom of the are adiabatic, two vertical walls have constant temperature lower than plate’s temperature. The flow assumed to be two-dimensional. discretized equations were solved finite difference method using Alternating Direction Implicit technique Successive OverRelaxation method. study was performed for different values Grashof number ranging from 103 105 aspect ratios position...
Acceleration of the reaction rate by polar organic solvents during both simple and complicated DNA strand replacement reactions is reported.
Correction for 'A photostable AIE fluorogen lysosome-targetable imaging of living cells' by Xiaoding Lou et al., J. Mater. Chem. B, 2016, 4, 5412-5417.