A5083396254- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Urologic and reproductive health conditions
- Multiple and Secondary Primary Cancers
- Ureteral procedures and complications
- Genetics and Neurodevelopmental Disorders
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Angiogenesis and VEGF in Cancer
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
Wuhan Institute of Technology
2023-2024
First Affiliated Hospital of Nanchang University
2015-2024
Nanchang University
2015-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Sichuan University
2021
West China Second University Hospital of Sichuan University
2021
Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3) has been reported to contribute tumorigenesis in several human cancers. However, the biological functions of IGF2BP3 bladder cancer are poorly understood. We investigated relation between expression and prognosis patients. Cell proliferation, cell cycle apoptosis assays were performed assess functions. The results showed that was overexpressed tissues compared with normal tissues, its higher closely correlated poor...
We combine the telomerase extension reaction and microRNA (miRNA)-induced rolling circle amplification, followed by graphene oxide (GO) nicking enzyme-assisted signal amplification as a method to analyze miRNA-21 in urine samples with following merits. First, it is binary assay can simultaneously output double signals that correspond quantities of miRNA, respectively. Second, activity enhanced using DNA molecular beacon probe inhibit formation G-quadruplex. Third, background noise decreased...
Few patients with prostate cancer benefit from current immunotherapies. Therefore, we aimed to explore new strategies change this paradigm. Human tissues, cell lines and in vivo experiments were used determine whether how N-cadherin impacts the production of programmed death ligand-1 (PD-L1) indole amine 2,3-dioxygenase (IDO-1) can increase effector (e)Treg cells. Then, PC3-bearing humanized non-obese diabetic/severe combined immunodeficiency IL2Rγnull (hNSG) mice an intravenous injection...
MicroRNAs are small non-coding RNAs, which critical regulators of carcinogenesis and tumor progression. Previous studies have identified that microRNA-20b (miR-20b) acts as an oncogene in numerous cancers. However, the role miR-20b prostate cancer remains unclear. The present study aimed to investigate expression examine whether modulating impacts cellular proliferation migration. It was revealed strongly expressed tissues compared with adjacent normal (P<0.05). Knockdown by inhibitor...
To describe in detail the techniques for transvesical robot-assisted radical prostatectomy (RARP) using da Vinci Si/Xi system (Intuitive Surgical, Sunnyvale, CA, USA) and to evaluate functional oncological outcomes 35 patients with prostate cancer.Thirty-five localized cancer were enrolled RARP. The patients' preoperative data (mean ± sd age 63.4 8.1 years, body mass index 28.6 5.3 kg/m2 , total prostate-specific antigen 10.8 4.9 ng/mL volume 30.6 14.4 mL, median [interquartile range {IQR}]...
Abstract The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replication, and repair. Loss of function the can cause neurodevelopmental disorder Williams syndrome. However, molecular mechanism underlying regulation prostate cancer remains largely elusive. Here, we report that deubiquitinating USP3 directly interacts with removes K63-linked polyubiquitination to maintain its stability, which promotes damage repair chemotherapy...
Immune evasion of cancer cells is mainly due to the impaired transduction apoptotic signals from immune cells, as well inhibition subsequent apoptosis signal cascades within cells. Over past few decades, research has focused more on rather than intracellular signaling pathways. In this study, miR‑221 inhibitor was transfected into bladder cell lines 5637, J82 and T24 repress expression miR‑221. As a result, repression p53 upregulated modulator (PUMA) abolished, resulting in increased...
To assess the perioperative, functional, and oncological outcomes of transvesical robot-assisted radical prostatectomy (T-RARP) posterior (P-RARP) for localized prostate cancer.We analyzed data 96 patients who underwent T-RARP or P-RARP cancer between January 2017 June 2019 in a retrospective fashion.No significant differences baseline characteristics existed arms. Both interventions were successfully performed without open conversion either group. was associated with slightly more operative...
Purpose: To explore the role of ORC6 in clear cell renal carcinoma (ccRCC). Methods: The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database was used to investigate association between expression and clinicopathological parameters. Furthermore, level determined human RCC tissues lines by western blot PCR. Receiver operating characteristics curves Kaplan-Meier were performed assess diagnostic prognostic value RCC. Results: High predicted shorter overall survival (OS)...
The regulation of initiation and progression during carcinogenesis bladder carcinoma is not completely elucidated. Dysregulation microRNAs has been detected to play critical roles in the development various cancers, including carcinoma, whereas involvement miR-223-3p tumorigenesis studied. Here, we show that significantly higher levels nuclear receptor coactivator 1 lower were tissue, compared adjacent non-tumor tissue. In addition, inversely correlated. Moreover, low specimens associated...
MLN4924 is a specific small-molecule inhibitor of NEDD8-activating enzyme (NAE) that blocks the neddylation modification cascade. Several I/II/III clinical trials suggested exerts an antitumor effect against various malignancies. However, recent studies have also found activates PI3K/AKT and MAPK/ERK signal pathways, important regulators tumorigenesis, drug resistance in human urothelial carcinoma (UC). This study examined synergistic celecoxib, cyclooxygenase-2 (COX-2) selective inhibitor,...
Background and Objectives : Bladder cancer (BC) is a complex tumor associated with high recurrence mortality. To discover key molecular changes in BC, we analyzed next-generation sequencing data of BC surrounding tissue samples from clinical specimens. Methods . Gene expression profiling datasets bladder were online. The Database for Annotation, Visualization, Integrated Discovery (DAVID, https://david.ncifcrf.gov/ ) was used to perform Ontology (GO) functional KEGG pathway enrichment...
The aim of the present study was to determine role androgen receptor in effect dexamethasone on cell proliferation and migration multiple prostate cancer cells. lines LNCaP, 22Rv1, C4‑2 PC3 were cultured vitro. For glucocorticoid‑induced experiments, cells transferred RPMI‑1640 medium with 10% charcoal‑stripped serum from fetal bovine for at least 24 h. effects various analyzed by MTT assays. Dexamethasone exhibited no 22Rv1 lines, but suppressed glucocorticoid (GR)+ (AR)‑ line. migration,...
Hypoxia is an essential hallmark of solid tumors and HIF1α a central regulator tumor cell adaptation survival in the hypoxic environment. In this study, we explored biological functions cycle division-related gene 8 (CDCA8) bladder cancer (BCa) cells settings. Specifically, found that CDCA8 was significantly upregulated BCa lines clinical samples its expression positively correlated with advanced stage, grade, poor overall (OS). The proteins required for to survive condition....
We aimed to analyze the perioperative, functional, and oncologic outcomes following robot-assisted radical prostatectomy (RARP) laparoscopic (LRP) for patients with localized prostate cancer (PCa) characterized by a large volume (PV; ≥50 ml) over minimum of 2 years follow-up.Patients undergoing RARP LRP PCa PV were included in final analysis. The analyzed between two groups.All operations successfully completed without open conversion both groups. mean operative time estimated blood loss...
BACKGROUND Bladder cancer caused by exposure to aniline dyes, chronic cystitis, and smoking is detected in approximately 70 000 new cases annually. In the USA alone, it leads 15 deaths every year. present study, we investigated role of 3-((4'-amino-[1,1'-biphenyl]-4-yl)amino)-4-bromo-5-oxo-2,5-dihydrofuran-2-yl acetate (ABDHFA) inhibition bladder cell viability. MATERIAL AND METHODS Viability cells was examined using MTT assay distribution cycle assessed flow cytometry. Expression cyclin D1,...
This study aimed to share a single institute experience of 4,380 procedures about in-traoperative serious complications laparoscopic urological surgeries. From January 2005 December 2013, cases surgeries were recruited in our department. The distribution, incidence, and characteristics intraoperative retrospectively sorted out analyzed. divided into three groups: very difficult (VD), (D), easy (E). com¬plication at Satava class II was defined be serious. One hundred thirty one with found...
To investigate the clinical and pathological features of metanephric adenoma (MA) outcome after retroperitoneal laparoscopic nephron-sparing surgery. Six out 183 partial nephrectomies performed during January 2009 to August 2014 were confirmed be MA by postoperative study. Perioperative parameters six patients then retrospectively collected, analyzed compared with current literature, including warm ischemia time (WIT), total operation time, estimated blood loss (EBL), positive surgical...
Abstract Purpose To study prognostic values of bladder neck involvement (BNI) and survival outcomes in non‐muscle‐invasive cancer (NMIBC). Method materials The national Surveillance, Epidemiology, End Results database (2004–2015) was applied to gain further insight into the BNI 19,919 patients diagnosed with NMIBC were included our study. We used Kaplan–Meier method log‐rank test subgroup analyses evaluate cancer‐specific (CSS) overall (OS). In addition, multivariable Cox proportional hazard...