A5100622009- Tuberculosis Research and Epidemiology
- Air Quality and Health Impacts
- Circular RNAs in diseases
- Climate Change and Health Impacts
- Diagnosis and treatment of tuberculosis
- COVID-19 epidemiological studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Herpesvirus Infections and Treatments
- Mycobacterium research and diagnosis
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Esophageal Cancer Research and Treatment
- Mitochondrial Function and Pathology
- Gastric Cancer Management and Outcomes
- COVID-19 impact on air quality
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Gastrointestinal Tumor Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Peptidase Inhibition and Analysis
- Infectious Diseases and Tuberculosis
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
Nanjing Medical University
2018-2025
Zhongshan Hospital
2024
Fudan University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2023-2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
Shaanxi Normal University
2020-2024
First Affiliated Hospital of Wannan Medical College
2024
Wannan Medical College
2024
Southeast University
2024
Immune checkpoint inhibitors have greatly improved the prognoses of diverse advanced malignancies, including gastric and gastroesophageal junction (G/GEJ) cancer. However, role anti-programmed cell death protein-1 treatment in neoadjuvant setting remains unclear. This phase 2 study aimed to evaluate sintilimab plus CapeOx as a regimen patients with resectable G/GEJ adenocarcinoma. Eligible adenocarcinoma stage cT3-4NanyM0 were enrolled. Patients received (3 mg/kg for cases <60 kg or 200...
The SARS-CoV-2 B.1.617.2 (Delta) variant has caused a new surge in the number of COVID-19 cases. effectiveness inactivated vaccines against this is not fully understood.Using data from recent large-scale outbreak infection Jiangsu, China, we conducted real-world study to explore effect vaccine immunization on course disease patients infected with Delta variant.Of 476 infection, 184 were unvaccinated, 105 partially vaccinated, and 187 vaccinated. A total 42 (8.8%) developed severe illness,...
The important role of miR-133a in the progress and development postmenopausal osteoporosis has been reported, however, underlying mechanism is not clear yet.In this study, qRT-PCR analysis was performed to assess miR-133 expression serum isolated from patients (PMOP) healthy controls.Bone mineral density (BMD) measured at lumbar spine by dual-energy X-ray absorptiometry (DXA).The results showed that significantly upregulated negatively correlated with BMD osteoporotic women.The mimic,...
Forecasting the seasonality and trend of pulmonary tuberculosis is important for rational allocation health resources; however, this foresting often hampered by inappropriate prediction methods. In study, we performed validation research comparing accuracy autoregressive integrated moving average (ARIMA) model back-propagation neural network (BPNN) in a southeastern province China.We applied data from 462,214 notified cases registered January 2005 to December 2015 Jiangsu Province modulate...
To explore the long-term effect of exposure to ambient air pollution on risk active tuberculosis (TB).We constructed a distributed-lag nonlinear model (DLNM) evaluate relatively influence outdoor PM2.5, PM10, SO2 and NO2 TB in city Lianyungang Jiangsu Province, China.There were 7,282 cases reported study area during 2014-2017, with annual median (interquartile range) concentrations at 45.86 (34.57-64.14) μg/m3, 85.43 (62.86-116.14) 22.00 (15.71-30.86) μg/m3 30.00 (23.29-38.57) respectively....
As a new class of endogenous ncRNAs, circRNAs have been recently verified to be involved in the carcinogenesis and progression human cancers. In current study, we attempted explore potential function candidate circRNA (hsa_circ_0000337) esophageal squamous cell carcinoma (ESCC).The altered expression hsa_circ_0000337 was validated clinical samples from 48 patients with ESCC. The lines KYSE-150 TE-1, normal epithelial line (HET-1A) were applied for functional analysis hsa_circ_0000337. Cell...
A variety of abnormalities in vitamin D metabolism have been reported patients with active tuberculosis. However, intervention trials produced inconsistent results. We hypothesized that genetic and epigenetic changes the key genes metabolic pathway may partly explain differences between studies. performed a case-control study followed by prospective cohort study. recruited 122 pulmonary tuberculosis 118 healthy controls. The serum 25-hydroxyvitamin 1,25-dihydroxyvitamin levels were measured....
Most studies on associations between meteorological factors and tuberculosis (TB) were conducted in a single city, used different lag times, or merely explored the qualitative TB. Thus, we performed multicenter study to quantitatively evaluate effects of risk pulmonary (PTB).We collected data newly diagnosed PTB cases 13 sites Jiangsu Province January 1, 2014, December 31, 2019. Data factors, air pollutants, socioeconomic at these during same period also collected. We applied generalized...
Mitochondria are dynamic organelles that important for cell growth and proliferation. Dysregulated mitochondrial dynamics highly associated with the initiation progression of various cancers, including ovarian cancer. However, regulatory mechanism underlying is still not fully understood. Previously, our study showed carnitine palmitoyltransferase 1A (CPT1A) expressed in cancer cells promotes development Here, we find CPT1A regulates fission cells. Our futher shows function through factor...
SPINAccepted Papers No AccessOptimization of dynamic mechanical behavior in aerospace structural design enhanced by quantum computingShuo Pei, Zhongqi Li, and Jinkun GaoShuo Li Search for more papers this author , Gao https://doi.org/10.1142/S2010324725400065Cited by:0 (Source: Crossref) PreviousNext AboutFiguresReferencesRelatedDetailsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend Library ShareShare onFacebookTwitterLinked InRedditEmail Cite Recommend We...
Objectives The detrimental effects of particulate matter (PM) on human health have been widely corroborated. We aimed to examine the association between outdoor PM and drug resistance risk among workers farmers with pulmonary tuberculosis (PTB). Design performed a population-based time-series study using routinely collected meteorological TB surveillance data. Setting selected Suzhou City, China, as area. Data patients PTB factors were extracted from National Tuberculosis Online Registration...
Phase change memory is emerging as a promising candidate for building up future energy efficient systems. To achieve high-performance and proportional design, phase devices need to be reorganized so that (1) the relatively long latency of should hidden; (2) unnecessary power waste preserved. Previous studies show conventional ranks could broken down into multiple smaller increased concurrency lower consumption. Nevertheless, electrical bus incapable supporting large number chips due its...
Abstract Background Tamoxifen resistance remains a significant clinical challenge for the therapy of ER-positive breast cancer. It has been reported that upregulation transcription factor SOX9 in ER + recurrent cancer is sufficient tamoxifen resistance. However, mechanisms underlying regulation remain largely unknown. Methods The acetylation level was detected by immunoprecipitation and western blotting. expressions HDACs SIRTs were evaluated qRT-PCR. Cell growth measured performing MTT...
Objective: To investigate suitable forecasting models for tuberculosis (TB) in a Chinese population by comparing the predictive value of autoregressive integrated moving average (ARIMA) model and ARIMA-generalized regression neural network (GRNN) hybrid model. Methods: We used monthly incidence rate TB Lianyungang city from January 2007 through June 2016 to construct fitting model, we July December evaluate accuracy. The root mean square error (RMSE), absolute percentage (MAPE), (MAE) (MER)...
The use of animal models human cytomegalovirus (HCMV) infection is critical to refine HCMV vaccine candidates. Previous reports have demonstrated that immunization rhesus monkeys against (RhCMV) can reduce both local and systemic replication RhCMV following experimental challenge. These studies used prime/boost combinations DNA expression plasmids alone or priming boosting with either inactivated virion particles modified vaccinia virus Ankara (MVA) expressing the same antigens. Viral...
Circular RNAs (circRNAs) function as efficient microRNA sponges with gene-regulatory potential and are promising cancer biomarkers. In this study, we used the Arraystar Human circRNA Array to construct a genome-wide profile of esophageal squamous cell (ESCC) breast (BC).Expression levels between lesions adjacent normal-appearing tissues were compared. We observed 469 upregulated circRNAs 275 downregulated in ESCC. Hsa_circRNA_103670 was 20.3-fold, while hsa_circRNA_030162 12.1-fold. For BC,...
Abstract Background Many studies have compared the performance of time series models in predicting pulmonary tuberculosis (PTB), but few considered role meteorological factors their prediction models. This study aims to explore whether incorporating can improve PTB. Methods We collected monthly reported number PTB cases and records six three cities China from 2005 2018. Based on this data, we constructed models, including an autoregressive integrated moving average (ARIMA) model, ARIMA with...
BackgroundThe Global Health Security (GHS) Index has been developed to measure a country's capacity cope with public health emergency; however, evidence for whether it corresponds the response global pandemic is lacking. This study performed multidimensional association analysis explore correlation between GHS and COVID-19-associated morbidity, mortality, disease increase rate (DIR) in 178 countries (regions).MethodsThe COVID-19 data – including total cases per million (TCPM), deaths (TDPM),...
We present PanGu-Coder, a pretrained decoder-only language model adopting the PanGu-Alpha architecture for text-to-code generation, i.e. synthesis of programming solutions given natural problem description. train PanGu-Coder using two-stage strategy: first stage employs Causal Language Modelling (CLM) to pre-train on raw data, while second uses combination and Masked (MLM) training objectives that focus downstream task generation loosely curated pairs program definitions code functions....