A5024060570- Cholangiocarcinoma and Gallbladder Cancer Studies
- Optical Wireless Communication Technologies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- Optical Systems and Laser Technology
- RNA modifications and cancer
- Antenna Design and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Advanced MIMO Systems Optimization
- Parathyroid Disorders and Treatments
- Microwave Engineering and Waveguides
- Renal Transplantation Outcomes and Treatments
- Infrared Target Detection Methodologies
- Network Packet Processing and Optimization
- Estrogen and related hormone effects
- Energy Harvesting in Wireless Networks
- Optical Network Technologies
- Cancer Mechanisms and Therapy
- Cognitive Radio Networks and Spectrum Sensing
- Gallbladder and Bile Duct Disorders
Hypertension Institute
2024
Wuhan College
2013-2023
Wenhua College
2023
Tao Yuan General Hospital
2023
McMaster University
2022
Zhejiang University
2015-2022
First Affiliated Hospital Zhejiang University
2018-2022
Guangdong Provincial Hospital of Traditional Chinese Medicine
2021
Hefei University of Technology
2012-2021
Beijing University of Posts and Telecommunications
2018-2020
Immune checkpoint inhibitors have greatly improved the prognoses of diverse advanced malignancies, including gastric and gastroesophageal junction (G/GEJ) cancer. However, role anti-programmed cell death protein-1 treatment in neoadjuvant setting remains unclear. This phase 2 study aimed to evaluate sintilimab plus CapeOx as a regimen patients with resectable G/GEJ adenocarcinoma. Eligible adenocarcinoma stage cT3-4NanyM0 were enrolled. Patients received (3 mg/kg for cases <60 kg or 200...
Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of gastric cancer; however, their mechanisms action remain largely unknown.The aim this study was to identify lncRNAs involved tumorigenesis cancer and investigate signaling pathways they affect.Using microarray RT-qPCR analyses, candidate were screened paired tissues.The analysis revealed MIR4435-2HG be markedly up-regulated samples compared normal stomach specimens.Increased expression associated with aggressive...
In this paper, we investigate the relay selection problem for two-way simultaneous wireless information and power transfer (SWIPT) enabled cognitive radio networks. The system consider includes a pair of primary users multiple secondary user transceivers, where transmitters are energy-constrained employ decode-and-forward scheme to assist transmission between users. Specifically, in order improve spectrum efficiency considered system, design novel communication protocol SWIPT-enabled...
Proliferation of some cultured human tumor cell lines bearing high numbers epidermal growth factor (EGF) receptors is paradoxically inhibited by EGF in nanomolar concentrations. In the present study, we have investigated biochemical mechanism inhibition A431 squamous carcinoma cells exposed to exogenous EGF. parallel, studied a selected subpopulation, A431-F, which resistant EGF-mediated inhibition. We observed marked reduction cyclin-dependent kinase-2 (CDK2) activity when and A431-F were...
Increasing evidence has shown that the transcription factor SOX4 is closely associated with development and progression of many malignant tumors. However, effect on breast cancer unclear. In this study, we purposed to investigate role in growth metastasis underlying mechanism. Moreover, cell resistance chemotherapeutic agents was also evaluated vitro vivo.We used lentivirus technique ectopically express MDA-MB-231 SUM149 cells or knockdown BT474 cells, examined these changes various cellular...
Abstract Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of cancer. However, little known about the genomic features this disease. We perform whole-exome sequencing analysis AFPGC, identify 34 significantly mutated genes. Somatic copy number alterations reveals several significant focal amplifications (e.g. 19q12, 17q12) deletions 1p36.11, 9p21.3), some these negatively affect patient prognosis. Comparative analyses reveal that AFPGC has distinct from...
Aims . Predicting the prognosis of gastric cancer using tumour-node-metastasis (TNM) staging is difficult as patients with same TNM stage exhibit different prognoses. Methods This study investigated prognostic value preoperative fibrinogen/albumin ratio (FAR)-systemic inflammation response index (SIRI) score in resectable (rGC). Results Clinicopathological features 231 rGC were analysed retrospectively. Patients divided into three groups: FAR-SIRI 2 (<mml:math...
Gastric cancer (GC) is one of the leading causes deaths with high heterogeneity. There currently a paucity clinically applicable molecular classification system to guide precise medicine.A total 70 Chinese patients GC were included in this study and whole-exome sequencing was performed. Unsupervised clustering undertaken identify genomic subgroups, based on mutational signature, copy number variation, neoantigen, clonality, essential alterations. Subgroups characterized by...
Claudin 18.2 (CLDN18.2), a tight junction (TJ) family protein controlling molecule exchange between cells, is frequently over-expressed in gastric cancer, pancreatic adenocarcinomas and fraction of non–small cell lung cancer cases. The tumor properties indicate that CLDN18.2 could be an attractive drug target for cancers. In this study, we present effective strategies developing anti-CLDN18.2 therapeutic candidates, based on variable domain heavy chain antibodies (VHHs). CLDN18.2-specific...
Non-small-cell lung cancer is one of the most lethal cancers in worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment aggressive non-small-cell cancers, Paclitaxel resistance emerges major clinical problem. It has demonstrated that Curcumin from Curcuma longa traditional Chinese medicine can inhibit cell proliferation. However, role Paclitaxel-resistant cells not clear. In this study, we investigated effect on and found markedly increased...
RNA-binding proteins (RBPs) and miRNAs are capable of controlling processes in normal development cancer. Both them could determine RNA transcripts fate from synthesis to decay. One such RBP, Dead end (Dnd1), is essential for regulating germ-cell viability suppresses the tumors development, yet how it exerts its functions breast cancer has remained unresolved. The level Dnd1 was detected 21 cancerous tissues paired with neighboring by qRT-PCR. We further annotated TCGA (The Cancer Genome...
Arterial calcifications increase arterial stiffness and are associated with a faster decline of kidney function in patients hypertension (AH) and/or chronic disease (CKD). Yet the underlying mechanisms linking calcifications, vascular renal incompletely understood. A novel in-vitro blood test evaluates propensity patient's serum to prevent formation by measuring maturation time calciprotein particles (CPP) [transformation amorphous calcium phosphate-containing primary CPP crystalline...
To observe the clinical effect of radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization (TACE) for advanced hepatocellular carcinoma (HCC).A total 92 cases primary liver cancer underwent TACE and RFA treatment from June 2005 to 2011 at Department Hepatobiliary Surgery, First Affiliated Hospital Bengbu Medical College. A 88 complete follow-up data were divided into two groups: 43 patients treated (TACE group) 45 that received + group). After assessment, tumor...
We aimed to assess the therapeutic effect of reimplantation biliary metal stents by percutaneous transhepatic cholangial drainage (PTCD) in patients with recurrent malignant obstructive jaundice (MOJ). Furthermore, we explored prognostic value inflammation-based markers these patients. reviewed 33 cases MOJ after implantation PTCD, all which underwent under digital subtraction angiography guidance. Levels alanine aminotransferase (ALT), aspartate (AST), and bilirubin were compared between...
BACKGROUND Worldwide, diabetes has become the most common cause of end-stage renal disease (ESRD), yet Swiss data are largely lacking. METHODS This observational study examined ESRD patients with mellitus (ESRD-DM) at end 2009 and 2014. The prevalence characteristics ESRD-DM were collected in all dialysis facilities Canton Vaud Switzerland 2014, 5-year mortality rate was assessed. RESULTS A total 107 140 underwent respectively. Within period a 167 incidental required dialysis, corresponding...
Aims It remains controversial to choose the optimal equation estimate glomerular filtration rate (GFR) in chronic kidney disease (CKD) patients with diabetes. Materials and Methods 215 diabetic CKD 192 non-diabetic were enrolled this study. Iohexol GFR, serum creatinine (SCr) Cystatin C(CysC) measured simultaneously for each patient. SCr- CysC-based estimated GFR (eGFR) calculated through eight equations, including three CKD-EPI Revised Lund-Malmö study (RLM), CAPA Full Age Spectrum (FAS)...