A5049431247- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Chromatin Remodeling and Cancer
- Glycosylation and Glycoproteins Research
- Cancer therapeutics and mechanisms
- Cancer Mechanisms and Therapy
- Brain Metastases and Treatment
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Insect Resistance and Genetics
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Fermentation and Sensory Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Single-cell and spatial transcriptomics
- Genetic and Kidney Cyst Diseases
- Reproductive tract infections research
- Virology and Viral Diseases
- Big Data and Business Intelligence
Affiliated Hospital of Hebei University
2025
Lanzhou University
2024
First Hospital of Lanzhou University
2024
Northeastern University
2020-2024
Qingdao Agricultural University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Southwest Jiaotong University
2022
Dana-Farber Cancer Institute
2013-2020
Cancer Hospital of Huanxing Chaoyang District Beijing
2020
National Clinical Research
2019
Abstract Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of cancer. However, little known about the genomic features this disease. We perform whole-exome sequencing analysis AFPGC, identify 34 significantly mutated genes. Somatic copy number alterations reveals several significant focal amplifications (e.g. 19q12, 17q12) deletions 1p36.11, 9p21.3), some these negatively affect patient prognosis. Comparative analyses reveal that AFPGC has distinct from...
Abstract Purpose After progression to immunotherapy, the standard of care for non-small cell lung cancer (NSCLC) was limited. Administration same or different immune checkpoint inhibitors (i.e., ICI rechallenge) may serve as a novel option. The present study aimed evaluate efficacy rechallenge NSCLC and explore prognostic factors. Methods In this retrospective cohort study, data advanced metastatic patients rechallenged with at Cancer Hospital, Chinese Academy Medical Sciences, Peking Union...
Abstract Introduction Dysregulated ARID1A expression is frequently detected in lung adenocarcinoma (LUAD) and mediates significant changes cancer behaviors a poor prognosis. deficiency LUAD enhances proliferation metastasis, which could be induced by activation of the Akt signaling pathway. However, no further exploration mechanisms has been performed. Methods Lentivirus was used for establishment knockdown (ARID1A-KD) cell line. MTS migration/invasion assays were to examine behaviors....
This research is dedicated to enhancing the accuracy and processing speed of grape disease recognition. As a result, real-time detection model named MSCI-YOLOv8s, based on an improved YOLOv8s framework proposed. The primary innovation this lies in replacing backbone network original with more efficient MobileNetV3. alteration not only strengthens ability capture features various manifestations leaf images but also improves its generalization capabilities stability. Additionally, incorporates...
Background Histologically, SCLC are classified as pure (P‐SCLC) and combined subtypes (C‐SCLC). Currently, few studies compare the clinicopathological characteristics explore treatment strategies applied to them. Methods Between July 2005 April 2016, clinical records of 297 postoperative patients with pathologically confirmed were retrospectively analyzed. Kaplan‐Meier method Cox regression model separately used for stratified univariate multivariate survival analysis. Results A total 46...
High-throughput genetic screening based on CRISPR/Cas9 or RNA-interference (RNAi) enables the exploration of genes associated with phenotype interest a large scale. The rapid accumulation public available data provides wealth knowledge about genotype-to-phenotype relationships and valuable resource for systematic analysis gene functions. Here we present CRISP-view, comprehensive database RNAi datasets that span multiple phenotypes, including in vitro vivo cell proliferation viability,...
Abstract Introduction EGFR mutations in non-small cell lung cancer (NSCLC) are associated with a poor response to immune checkpoint inhibitors (ICIs), and only 20% of NSCLC patients harboring benefit from immunotherapy. Novel biomarkers or therapeutics needed predict prognosis enhance the efficacy ICIs mutations, especially adenocarcinoma (LUAD) patients, who account for approximately 40–50% all cases. Methods An ARID1A-knockdown (ARID1A-KD) -mutant LUAD line was constructed using...
Abstract Objective Small cell lung cancer (SCLC) is one of the most aggressive malignancies characterized by neuroendocrine (NE) differentiation. The Delta‐like protein 3 (DLL3), as a direct downstream target ASCL1, involved in NE differentiation and carcinogenesis SCLC. This study aims to investigate relationship between ASCL1 DLL3 expressions their clinicopathological implications Methods A total 247 surgically resected pure SCLC samples with limited clinical stage follow‐up data were...
There is a need for the development of therapies to delay cancer progression and prolong survival after initial chemotherapy treatment small cell lung (SCLC). Since apatinib has been found exert promising effects on patients standard first-line chemotherapy, this study aimed investigate as maintenance following in extensive disease (ED)-SCLC.
The objective of this study was to analyze the clinical and pathological characteristics patients with small cell lung cancer (SCLC) after curative surgery explore prognostic factors for disease-free survival (DFS) overall (OS). Clinical data 247 were collected, clinicopathological features retrieved, including gender, age, smoking history, tumor location, distant metastasis. Histopathological also reviewed by three pathologists, primary (T), lymph node metastasis (N), pleural invasion,...
Preeclampsia (PE) and endometrial cancer (EC) are two distinct conditions that share common genetic molecular mechanisms involving immune dysregulation, endothelial dysfunction, angiogenesis. This study aimed to investigate the potential links between PE EC, identify key prognostic genes, develop a risk model predict overall survival in EC patients. We conducted comprehensive analyses, revealing significant overlaps angiogenic pathways EC. Through LASSO regression multivariate Cox analysis,...
在更多不同的情境下提高研究的生态 效度, 同时采用更多的人格评价手段。
Abstract Brain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis matched primary tumors (PT) and their BM lesions may provide new insight into evolutionary immune characteristics. To describe features characteristic differences, we analyzed whole-exome sequencing data 28 paired PT samples 14 non-small cell cancer. In addition, used another 26 as a...
Summary Drugs that block the activity of methyltransferase EZH2 are in clinical development for treatment non-Hodgkin lymphomas harboring gain-of-function mutations enhance its polycomb repressive function. In contrast, castration-resistant prostate cancer (CRPC) we have previously reported plays a non-canonical role as transcriptional activator. this setting, now show inhibitors can also and inhibit growth CRPC cells. Gene expression epigenomic profiling cells treated with demonstrated...
Abstract A major challenge in the application of CRISPR-Cas13d (RfxCas13d, or CasRx) RNA editing system is to accurately predict its guide (gRNA) dependent on-target and off-target effect. Here, we performed proliferation screens that target protein-coding genes long non-coding RNAs (lncRNAs), followed by a systematic modeling Cas13d efficiency viability We first designed deep learning model, named DeepCas13, activity gRNA with high accuracy from sequence secondary structure. DeepCas13...
<h3>Introduction</h3> Since 1980s, sexually transmitted diseases (STD) reappeared in mainland China and the reported cases increased over years, Ministry of Public Health set up national STD surveillance system to monitor trends. The results showed that gonorrhoea was a prevalent became an important public health issue. However, since 2000, incidence had decreased. In order understand trends epidemiological features recent 14 years China, we conduct analysis data from system....