A5041966388- Lung Cancer Treatments and Mutations
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Cancer-related cognitive impairment studies
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Digestive system and related health
- PI3K/AKT/mTOR signaling in cancer
- Plant Pathogens and Resistance
- Colorectal Cancer Treatments and Studies
- Intravenous Infusion Technology and Safety
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Central Venous Catheters and Hemodialysis
- Patient Safety and Medication Errors
Maastro Clinic
2024
Maastricht University Medical Centre
2024
Yantai University
2024
Tianjin University of Traditional Chinese Medicine
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Peking Union Medical College Hospital
2022-2023
Next-generation sequencing (NGS) has failed to detect mesenchymal epithelial transition factor gene (MET) polysomy in previous studies. We included three non–small cell lung cancer (NSCLC) cohorts this retrospective study establish new criteria for detecting MET and explore the clinical relevance of polysomy. Cohort 1 53 patients whose tissues were available both FISH NGS assays. Paired plasma tissue samples obtained from 261 with NSCLC as cohort 2. 3 46 metastatic NSCLC, who presented...
Anemone shikokiana (Makino) Makino is a perennial herb of the genus in family Ranunculaceae. Endemic to Shandong Peninsula China and Shikoku Island Japan, it rare endangered plant with narrow, disjunct distribution. It threatened extinction urgent need conservation. Evaluating genetic diversity species, revealing population structure gene flow, inferring history are great importance for species conservation, especially plants. In our study, 73 samples from eight wild populations were...
Abstract Brain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis matched primary tumors (PT) and their BM lesions may provide new insight into evolutionary immune characteristics. To describe features characteristic differences, we analyzed whole-exome sequencing data 28 paired PT samples 14 non-small cell cancer. In addition, used another 26 as a...
The prognosis of patients with SCLC is poor, and the 5-year survival rate less than 5%. Brain metastasis most common secondary SCLC, it also important factor in progression disease. This study combined WGCNA mfuzz algorithm to identify potential biomarkers peripheral blood brain metastases. By comparing significantly differentially expressed genes present BMS samples, we identified ADCY4 as a target for further study. expression level was used cluster pattern, 28 Hub functional enrichment....
<p>The TMB distribution of all primary and metastases samples. The total (defined as the number nonsynonymous mutations) in each group.</p>
<p>The basic clinical information of all patients.</p>
<p>Supplementary Figure 1. The TMB distribution of all primary and metastases samples. total (defined as the number nonsynonymous mutations) in each group.Supplementary Table basic clinical information patients.</p>
<div>Abstract<p>Brain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis matched primary tumors (PT) and their BM lesions may provide new insight into evolutionary immune characteristics. To describe features characteristic differences, we analyzed whole-exome sequencing data 28 paired PT samples 14 non-small cell cancer. In addition, used...
<p>Supplementary Figure 1. The TMB distribution of all primary and metastases samples. total (defined as the number nonsynonymous mutations) in each group.Supplementary Table basic clinical information patients.</p>
<div>Abstract<p>Brain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis matched primary tumors (PT) and their BM lesions may provide new insight into evolutionary immune characteristics. To describe features characteristic differences, we analyzed whole-exome sequencing data 28 paired PT samples 14 non-small cell cancer. In addition, used...
<p>The TMB distribution of all primary and metastases samples. The total (defined as the number nonsynonymous mutations) in each group.</p>
<p>The basic clinical information of all patients.</p>
<p>One MET-FISH-negative patient was classified as having MET polysomy by NGS</p>
<p>Flowchart of the study design</p>
<p>One MET-FISH polysomy tumor was classified as negative using the NGS assay.</p>
<p>The detection process using NGS of the study.</p>
<p>Summary of MET status tested by NGS, inhibitors with clinical outcome and dynamic changes in gene alterations cohort 3</p>
<p>Clinicopathologic characteristics of patients in cohort 3.</p>
<div>Abstract<p>Next-generation sequencing (NGS) has failed to detect mesenchymal epithelial transition factor gene (MET) polysomy in previous studies. We included three non-small cell lung cancer (NSCLC) cohorts this retrospective study establish new criteria for detecting MET and explore the clinical relevance of polysomy. Cohort 1 53 patients whose tissues were available both fluorescence in-situ hybridization (FISH) NGS assays. Paired plasma tissue samples obtained from 261...
<div><p>Next-generation sequencing (NGS) has failed to detect mesenchymal epithelial transition factor gene (<i>MET</i>) polysomy in previous studies. We included three non–small cell lung cancer (NSCLC) cohorts this retrospective study establish new criteria for detecting <i>MET</i> and explore the clinical relevance of polysomy. Cohort 1 53 patients whose tissues were available both FISH NGS assays. Paired plasma tissue samples obtained from 261 with...
<p>One MET-FISH-positive tumor was identified as negative by NGS</p>
<p>The detection process using NGS of the study.</p>
<p>One MET-FISH-negative patient was classified as having MET polysomy by NGS</p>