A5100672507- CRISPR and Genetic Engineering
- Image Processing Techniques and Applications
- Cell Image Analysis Techniques
- Computational Drug Discovery Methods
- interferon and immune responses
- Bacterial biofilms and quorum sensing
- Electrocatalysts for Energy Conversion
- Nanomaterials for catalytic reactions
- Image Retrieval and Classification Techniques
- Cyclopropane Reaction Mechanisms
- Force Microscopy Techniques and Applications
- Advanced Photocatalysis Techniques
- Pharmacological Effects of Natural Compounds
- Advanced battery technologies research
- Plant-based Medicinal Research
- RNA Interference and Gene Delivery
- Andrographolide Research and Applications
- Mosquito-borne diseases and control
- Biosensors and Analytical Detection
- RNA Research and Splicing
- Iron-based superconductors research
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Physics of Superconductivity and Magnetism
- Graphene research and applications
Wuhan Institute of Technology
2025
Northeastern University
2017-2025
Wuhan University of Technology
2023-2025
Nanjing Agricultural University
2022-2024
Fudan University
2020-2024
Northeastern University
2024
Chinese Center For Disease Control and Prevention
2024
Tsinghua University
2024
Center for Life Sciences
2024
Foshan University
2024
Novel aqueous hybrid ion capacitors based on an MB functionalized graphene cathode and asymmetric electrolytes exhibited both improved energy density power density.
Abstract A major challenge in the application of CRISPR-Cas13d system is to accurately predict its guide-dependent on-target and off-target effect. Here, we perform proliferation screens design a deep learning model, named DeepCas13, activity from guide sequences secondary structures. DeepCas13 outperforms existing methods efficiency guides targeting both protein-coding non-coding RNAs. Guides non-essential genes display viability effects, which are closely related their efficiencies....
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens seven chemotherapeutic agents in multiple cancer cells. Chemoresistance genes vary between conditions primarily due distinct background and mechanism action drugs, manifesting heterogeneous multiplexed routes towards chemoresistance. By focusing on...
As a new wave of technological and industrial revolution accelerates, the fusion evolution societal development is reshaping industries, with digitalization emerging as potent force in competitive landscapes. Artificial Intelligence (AI) has progressively permeated various sectors, including finance, its application finance holds promise enhancing efficiency service quality for financial institutions Its institutions, thereby offering improved experiences clients. Among these applications,...
Genome editing holds great promise for the molecular breeding of plants, yet its application is hindered by shortage simple and effective means delivering genome reagents into plants. Conventional plant transformation-based methods delivery plants often involve prolonged tissue culture, a labor-intensive technically challenging process many elite crop cultivars. In this review, we describe various virus-based that have been employed to deliver reagents, including components CRISPR/Cas...
Optically pure homoallylic alcohols are important synthons for natural products and bioactive compounds, which can be assembled by the chiral phosphoric acid-catalyzed asymmetric allylboration of aldehydes. Based on this reaction, two unprecedented cascade reactions functionalized aldehydes (allylation/oxa-Michael or oxa-Pictet−Spengler reactions) synthesis 2,5-disubstituted 2,2,5-trisubstituted tetrahydrofurans using a single acid catalyst have been developed. The reaction mechanism was...
Abstract The solid tumor microenvironment is a key determinant of successful cancer therapy, with hypoxic cells known to contribute poor therapeutic outcome after radiation chemotherapy, and surgery. Several targeted therapies have been developed against that shown promise in combination therapy pre-clinical models early phase clinical trials, although the difficulty inherent targeting has limited overall efficacy this approach. Our recent data suggest hypoxia can develop tumors due activity...
<title>Abstract</title> The rapid growth of lithium-ion batteries (LIBs) is lighting a more sustainable transportation driven by electric vehicles. However, the end-of-life LIBs in next decades will pose key challenges to resource economy and environment due lack their high-value reuse. Here, we show high-value, sustainable, kilogram-scale upcycling strategy convert spent cathode materials into NiCoMnFeP (NCMFP) electrocatalysts. These catalysts exhibit gradient nanoparticle assembly...
The main obstacle to image augmentation with Generative Adversarial Networks (GANs) is the need for a large amount of training data, but this difficult small datasets like Environmental Microorganisms (EMs). EM analysis plays vital role in environmental monitoring and protection, it often encountered due difficulty collection. To end, we propose an Enhanced Framework GANs (EF-GANs) that combines geometric transformation methods augmentation. First all, color has insignificant impact on its...
Glaucoma is an acquired optic neuropathy, which can lead to irreversible vision loss. Deep learning(DL), especially convolutional neural networks(CNN), has achieved considerable success in the field of medical image recognition due availability large-scale annotated datasets and CNNs. However, obtaining fully like ImageNet still a challenge. Meanwhile, single-modal approaches remain both unreliable inaccurate diversity glaucoma disease types complexity symptoms. In this paper, new multimodal...
A variety of furo[2,3-e][1,4]diazepin-3-one derivatives were facilely synthesized through one-pot tandem cyclization/[4 + 3] annulation reactions between enynamides and α-bromohydroxamates. The proceeded efficiently at room temperature, various functional groups well tolerated. obtained furo[2,3-e][1,4]diazepin-3(2H)-ones containing a 7-membered dinitrogen-fused ring might be biological medicinal value. products could further derived using convenient procedures.
Pd-Pd/PdO nanoclusters well dispersed on intercalated graphene oxide (GO) (denoted as GO@PPD-Pd) were prepared and characterized. GO@PPD-Pd exhibited high catalytic activity (a TOF value of 60 705 h