A5005759115- Diet and metabolism studies
- Folate and B Vitamins Research
- Gut microbiota and health
- Esophageal and GI Pathology
- Dietary Effects on Health
- Renal and related cancers
- Tryptophan and brain disorders
- Genetic and Kidney Cyst Diseases
- Renal cell carcinoma treatment
- Mesenchymal stem cell research
- Nutritional Studies and Diet
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Nutrition and Health in Aging
- Hematopoietic Stem Cell Transplantation
- Eating Disorders and Behaviors
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Diabetes Management and Research
- Berberine and alkaloids research
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Ginseng Biological Effects and Applications
University of Southern California
2020-2024
Chinese PLA General Hospital
2016-2023
Chinese People's Liberation Army
2023
Brigham and Women's Hospital
2020
Broad Center
2020
Xiyuan Hospital
2016-2018
Zero to Three
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2016
Scope It has been demonstrated that a mutation of MTHFR C677T increases plasma total homocysteine (Hcy) concentration and decreases folate. Natural foods can improve Hcy levels, but the effect certain remains undetermined. The aim this study was to investigate association between food groups Hcy, explore correlations dietary folate/vitamin (Vit) B12 for genotype‐specific population. Methods results A 4507 adults were enrolled in study, all whom underwent physical examinations genotyping....
Abstract New strategies of autologous hematopoietic stem cell transplantation (auto-HSCT) have gained much interest for the treatment type 1 diabetes mellitus. However, assessing clinical response and residual β-cell function still has limitations. The aim study was to select optimal quantitative index assess pre-existing explore its predictive after auto-HSCT therapy. In this study, all patients who had undergone were clustered into a responder group (Δβ-score > 0) nonresponder ≤ 0)....
Background: Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine (Hcy) metabolism. A common C677T mutation the MTHFR gene results decreased activity, which contributes to hyperhomocysteinemia (HHcy). Previous studies have shown that HHcy was correlated with various systemic diseases, such as cardiovascular disease, stroke, cancer, renal failure and so on. However, we hypothesized different genotype sex groups may risk factors, would lead pathologic states....
To investigate the associations among methylene tetrahydrofolate reductase rs1801133 C677T gene variant, food groups, and risk of non-alcoholic fatty liver disease in Chinese population.A study polymorphism was conducted using polymerase chain reaction method. A total 4,049 adults participated study, all underwent physical examination genotyping. Participants filled out a dietary questionnaire to enable us assess frequency quantity consumption.The important variables identified as factors...
Objective Intermittent energy restriction (IER) is an effective weight loss strategy. However, little known about the dynamic effects of IER on brain-gut-microbiome axis. Methods In this study, a total 25 obese individuals successfully lost after 2-month intervention. FMRI was used to determine activity brain regions. Metagenomic sequencing performed identify differentially abundant gut microbes and pathways in from fecal samples. Results Our results showed that longitudinally reduced...
Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of kidney. Here we report manipulation p38 YAP activity creates a synthetic niche that allows long-term clonal expansion primary mouse human NPCs, induced NPCs (iNPCs) from pluripotent stem cells. Cultured iNPCs resemble closely generating nephron organoids with abundant distal convoluted tubule cells, which are not observed in published kidney organoids. The reprograms differentiated NPC state,...
Background Intermittent energy restriction (IER) is an effective weight loss strategy. However, the accompanying changes in spontaneous neural activity are unclear, and relationship among anthropometric measurements, biochemical indicators, adipokines remains ambiguous. Methods Thirty-five obese adults were recruited received a 2-month IER intervention. Data collected from blood samples, resting-state functional magnetic resonance imaging at four time points. The regional homogeneity (ReHo)...
Abstract BackgroundHuman adipose derived mesenchymal stem cells (ASCs) are ideal candidates for the treatment of acute myocardial infarction (AMI), due to their favorable availability and regenerative potential. However, in vivo studies showed that ASCs not resilient at infarcted area, a shortage blood oxygen supply. Hypoxic pretreatment was proven be an effective way enhance cell survival ischemic atmosphere. Moreover, co-transplantation another promising strategy improve cardiac function...
Abstract Background- - Our previous studies have identified that both gender and genotype of MTHFR C677T were independent variables for plasma homocysteine (Hcy) levels. Based on these results, we want to further explore their systemic information, in order find specific risk factors each genetic group, which might be used as predictors or targeting markers lowering Hcy Patients Methods-- This cross section study was performed through November 2017 July 2019. A total 4534 adults aged...
Abstract Calorie restriction (CR) has been widely recognized for its effect in reducing body weight and alleviating diabetes humans, as well prolonging life span animal studies. Gut microbiome shifts contribute to part of the effects CR, but little is known regarding their influences except on metabolism immunity. Here we monitored gut using metagenomics metatranscriptomics obese individuals undergoing revealed microbial determinants that could successful loss. Microbiome changes are linked...
Abstract Background: Calorie restriction (CR) has been widely recognized for its effect in reducing body weight and alleviating diabetes humans, as well prolonging life span animal studies. Gut microbiome shifts contribute to part of the effects CR, but little is known regarding their influences except on metabolism immunity. Methods: We combined human population-based (metagenomic, metatranscriptomics shotgun sequencing data) mice-based approaches revealed microbial determinants that could...