A5026350219- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Protein Interaction Studies and Fluorescence Analysis
- Neutropenia and Cancer Infections
- Bioactive natural compounds
- Physical Activity and Health
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chemokine receptors and signaling
- Glaucoma and retinal disorders
- Liver physiology and pathology
- Sirtuins and Resveratrol in Medicine
- Gestational Trophoblastic Disease Studies
- Chromatin Remodeling and Cancer
- Machine Learning in Bioinformatics
- Computational Drug Discovery Methods
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Northwest A&F University
2024
China-Japan Friendship Hospital
2023-2024
Peking Union Medical College Hospital
2023-2024
Beijing University of Chinese Medicine
2023
Institute of Hematology & Blood Diseases Hospital
2022
Henan Normal University
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2021
National Clinical Research
2021
ORCID
2021
The FAS-FASL system plays crucial role in counterattack of cancer cell against immune system. This study examined the effects FAS (-1377G/A and -670A/G) FASL (-844T/C 7896G/C) polymorphisms on breast risk apoptosis T lymphocytes. effect was determined by case-control analysis 840 patients controls. T-lymphocyte were activation-induced death (AICD) cells ex vivo analyzing apoptotic tumor-infiltrating lymphocytes (TILs) tissue. We found moderately increased associated with -1377AG [odds ratio...
Small-cell lung cancer (SCLC) is generally considered a 'homogenous' disease, with little documented inter-tumor heterogeneity in treatment guidance or prognosis evaluation. The precise identification of clinically relevant molecular subtypes remains incomplete and their translation into clinical practice limited. In this retrospective cohort study, we comprehensively characterized the immune microenvironment SCLC by integrating transcriptional protein profiling...
Background Histologically, SCLC are classified as pure (P‐SCLC) and combined subtypes (C‐SCLC). Currently, few studies compare the clinicopathological characteristics explore treatment strategies applied to them. Methods Between July 2005 April 2016, clinical records of 297 postoperative patients with pathologically confirmed were retrospectively analyzed. Kaplan‐Meier method Cox regression model separately used for stratified univariate multivariate survival analysis. Results A total 46...
Recently, expression of YAP1, a nuclear effector an inactivated HIPPO pathway, has been identified as one four molecular subtypes SCLC. However, the clinicopathological relevance and prognostic significance YAP1 in SCLC stratified by histological not systematically reported to date.Tumor sections corresponding formalin-fixed paraffin-embedded (FFPE) samples 297 patients were retrieved from pathological specimen repository subsequently reviewed pathologists. Forty-six C-SCLCs (combined SCLCs)...
The genetic characteristics of rectal neuroendocrine tumors (R-NETs) were poorly understood. Depicting the may provide a biological basis for prognosis prediction and novel treatment development. Tissues 18 R-NET patients analyzed using whole-exome sequencing. median tumor mutation burden (TMB) microsatellite instability (MSI) 1.15 Muts/MB (range, 0.03-23.28) 0.36 0.00-10.97), respectively. Genes involved in P53 signaling, PI3K-AKT DNA damage repair, WNT etc. frequently altered. Higher TMB...
Although evidence indicates that drug target genes share some common evolutionary features, there have been few studies analyzing features of targets from an overall level. Therefore, we conducted analysis which aimed to investigate the characteristics genes. We compared conservation between human and non-target by combining both network topological properties in protein-protein interaction network. The evolution rate, score percentage orthologous 21 species were included our study....
Clinical evidence has shown that few non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations can benefit from immunotherapy. The tumor immune microenvironment (TIME) is a significant affecting the efficacy of However, TIME transformational process in EGFR-mutation unknown.The mRNA expression and mutation data adenocarcinoma (LUAD) clinical were obtained Cancer Genome Atlas (TCGA) database. Profiles describing landscape EGFR characterized by...
The objective of this study was to analyze the clinical and pathological characteristics patients with small cell lung cancer (SCLC) after curative surgery explore prognostic factors for disease-free survival (DFS) overall (OS). Clinical data 247 were collected, clinicopathological features retrieved, including gender, age, smoking history, tumor location, distant metastasis. Histopathological also reviewed by three pathologists, primary (T), lymph node metastasis (N), pleural invasion,...
Treatment response to the standard therapy is low for metastatic pancreatic neuroendocrine tumors (PanNETs) mainly due tumor heterogeneity. We investigated heterogeneity between primary PanNETs and metastases improve precise treatment.The genomic transcriptomic data of were retrieved from Genomics, Evidence, Neoplasia, Information, Exchange (GENIE), Gene Expression Omnibus (GEO) database, respectively. Potential prognostic effects gene mutations enriched in investigated. set enrichment...
An electrophoretically slowly moving hemoglobin variant, Hb Quin-Hai was found in an 8-year-old boy and his father, during a survey for abnormal hemoglobins County, Hainan Island, Guangdong, P.R.C. Both carriers were clinically hematologically normal. Structural studies indicated new variant 378 (EF2) Leu→Arg.
Background Small cell lung cancer (SCLC) is one of the most aggressive cancers. Treatment SCLC has remained unchanged during past decades. Preclinical studies have revealed ASCL1 as a transcription regulator in neuroendocrine (NE) differentiation and carcinogenesis SCLC. However, there are few on correlation expression clinicopathological factors resected SCLCs. Here, we aimed to analyze investigate its associations with survival. Methods A total 247 surgically pure specimens were included...
To explore the relationship of sleep duration and insomnia with muscle mass, strength, quality in Chinese adults.
The incidence of lung cancer is growing fast in China, however, the prognosis remains dismal due to limited therapeutic approaches. "ret proto-oncogene mutation" (RET) fusions have been proven be driver gene development and target several multi-target tyrosine kinase inhibitors.We applied formalin-fixed, paraffin-embedded (FFPE) samples 39 patients with non-small cell (NSCLC) using Lung Plasma panel covering 168 cancer-associated genes performed capture-based targeted deep sequencing...
Marine fog poses a significant hazard to global shipping, necessitating effective detection and forecasting reduce economic losses. In recent years, several machine learning (ML) methods have demonstrated superior accuracy compared traditional meteorological methods. However, most of these works are developed on proprietary datasets, the few publicly accessible datasets often limited simplistic toy scenarios for research purposes. To advance field, we collected nearly decade's worth...
Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a rare group of diseases with poor prognosis and the assessment its significant challenge. This study aimed to develop validate prognostic nomogram assess overall survival (OS) in patients GEP-NEC.
The roles of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in solid tumors are well established. However, the interaction between CSCs EMT pulmonary large cell neuroendocrine carcinoma (LCNEC) remains unknown. aim this study was to investigate expression clinical significance a CSC marker (ALDH1A1) its correlation with Epithelial-like phenotype (E-cadherin) Mesenchymal-like (N-cadherin) LCNEC patients.Immunohistochemistry (IHC) for ALDH1A1, E-cadherin N-cadherin...
Objective: To explore the relationship of physical activity and sedentary leisure time with muscle mass, strength, quality in Chinese adults. Methods: Based on second resurvey China Kadoorie Biobank (CKB) 2013-2014, logistic regression models were used to analyze correlation low grip quality. Results: A total 24 245 participants included analysis. The average daily level was (18.3±13.8) MET-h/d, (4.4±1.9) hours. We took lowest quartile as reference found that participants' negatively...
Objective: To examine the associations of childhood obesity, assessed by genetic variations body mass index (BMI), with risk adult ischemic heart disease (IHD) and major coronary event (MCE). Methods: More than 69 000 participants from China Kadoorie Biobank were genotyped. After excluding those disease, stroke, or cancer at baseline, a total 64 454 included in this study. Based on genome-wide significant single nucleotide polymorphisms (SNPs), BMI score constructed for every participant...
Background: As a rare, aggressive pediatric myeloproliferative disease, juvenile myelomonocytic leukemia (JMML) encompassed both biological features of myelodysplastic syndrome and neoplasm. Studies have shown that the methylation level in JMML patients is closely related to prognosis, with high poor prognosis. Aims: This study aimed find clinical indicators were associated different levels Methods: The information 24 DNA samples admitted our center from December 2013 May 2020 was...
Background: Neutropenic children with hematological diseases were associated higher morbidity of carbapenem-resistant enterobacteriaceae (CRE) blood-stream infection (BSI) or colonization. Aims: We aimed to identify the clinical characteristics and outcome caused by CRE-BSI. Methods: 2465 consecutive neutropenic enrolled. Antimicrobial susceptibility CRE strains explored potential factors subsequent CRE-BSI 30-day survival probability assessed. Results: CRE-carriers identified in 59/2465...