A5100320321- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 Clinical Research Studies
- Early Childhood Education and Development
- SARS-CoV-2 and COVID-19 Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child Abuse and Trauma
- Finite Group Theory Research
- graph theory and CDMA systems
- Birth, Development, and Health
- HIV/AIDS drug development and treatment
- Pregnancy and preeclampsia studies
- COVID-19 and Mental Health
- HIV Research and Treatment
- Cardiovascular Health and Risk Factors
- Rough Sets and Fuzzy Logic
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tryptophan and brain disorders
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Speech and Audio Processing
- China's Socioeconomic Reforms and Governance
- Hearing Loss and Rehabilitation
- Innovative Energy Harvesting Technologies
- Fetal and Pediatric Neurological Disorders
Hebei Normal University
2006-2025
Zhejiang University
2023-2025
Xuzhou Medical College
2020-2025
Merck & Co., Inc., Rahway, NJ, USA (United States)
2020-2025
Harvard University
2023-2025
Brigham and Women's Hospital
2023-2025
University of Iowa
2017-2024
Sichuan Normal University
2024
Texas A&M Health Science Center
2024
Second Affiliated Hospital of Zhejiang University
2024
No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes respiratory Covid-19, and an oxygen saturation (Sao2) 94% or less while they were breathing ambient air ratio partial pressure (Pao2) to fraction inspired (Fio2) than 300 mm Hg. Patients randomly assigned in 1:1 receive either lopinavir-ritonavir...
Abstract The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. symptoms COVID-19 range from mild to severe, but physiological changes associated with are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses plasma cohort patients who had experienced different symptoms. We found that metabolite lipid alterations exhibit apparent correlation course in these patients, indicating development affected their...
Respiratory Syncytial Virus (RSV) causes lower respiratory tract infections that can be severe and sometimes fatal. The risk for RSV infection is highest in infants older adults. A safe effective vaccine adults represents a serious unmet medical need due to higher morbidity mortality this age group. In randomized, partially double-blind, placebo-controlled, phase 1 dose-escalation study, we evaluated the safety, tolerability immunogenicity of an investigational messenger ribonucleic acid...
SARS-CoV-2-specific adaptive immunity more than 1 year after initial infection has not been well characterised. The aim of this study was to investigate the durability and cross-reactivity immunological memory acquired from natural against SARS-CoV-2 in individuals recovered COVID-19 2 years infection.
This study validated a Chinese adaptation of the Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CCA), self-report instrument that evaluates two emotion regulation (ER) strategies, based on process model ER. The ERQ-CCA was evaluated using sample 1381 children aged between 7 12 years. internal consistencies factors indicated adequate reliability. Confirmatory factor analysis (CFA) revealed good support as structure proved to be identical with original instrument....
Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, quality control of CP and individual variation patients different studies make it rather difficult to evaluate efficacy risk coronavirus disease 2019 (COVID-19). We aimed explore potential therapy, assess possible factors associated with its efficacy. enrolled eight critical or severe COVID-19 from four centers. Each patient was transfused 200-400 mL...
The development of new and improved antiretroviral therapies that allow for alternative dosing schedules is needed people living with HIV-1. Islatravir a deoxyadenosine analog in the treatment HIV-1 suppresses replication via multiple mechanisms action, including reverse transcriptase translocation inhibition delayed chain termination. differentiated from other antiretrovirals by its high potency, long t½, broad tissue distribution, favorable drug resistance profile. A comprehensive...
This study aimed to evaluate the association of lactation duration with incident ischemic heart disease (IHD) and determine potential health gains from scaling up breastfeeding practice. 130,147 parous postmenopausal females without IHD were included at baseline (2004–2008) China Kadoorie Biobank study. Lactation was self-reported measured as lifetime, per child, first respectively. Incident identified during follow-up (2004–2015). The dose-response associations between examined using Cox...
Abstract In Alzheimer’s disease, perturbations of glutamate neurotransmission lead to synaptic dysfunction and synapse loss. Several studies have used transport inhibitors demonstrate that soluble oligomers amyloid-β induce by interrupting uptake mediated transporter 1, the major in brain. The cellular targets effects oligomers, including nature any interaction with remain ill-defined. We generated a conditional 1 knockout mouse investigate celltype specific functions 1. Field excitatory...
Abstract The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. symptoms COVID-19 range from mild to severe conditions. However, physiological changes associated with are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses plasma cohort patients who had experienced different symptoms. We found metabolite lipid alterations exhibit apparent correlation course in these patients, indicating that development...
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and essential for viral replication. Recently, IN inhibitors have emerged as a new promising class therapeutics. Herein, we report discovery azaindole carboxylic acids hydroxamic potent enzyme their structure-activity relationships. Several 4-fluorobenzyl substituted showed antiviral activities in cell-based assays offered structurally simple scaffold development novel inhibitors.
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and essential for viral replication, IN inhibitors have emerged as a new promising class therapeutics. Recently, we reported synthesis orally bioavailable azaindole hydroxamic acids that were potent enzyme. Here disclose design novel tricyclic N-hydroxy-dihydronaphthyridinones potent, displaying excellent ligand lipophilic efficiencies.
Background Increasing evidence has suggested that major depression ( MD ) is associated with an increased risk of ischemic heart disease IHD ). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million aged 30 to 79 years were followed baseline interview (2004–2008) until December 31, 2013. Past year was measured modified version Composite International Diagnostic Interview‐Short Form at baseline. Incident cases...
Using data collected from two provinces in China through an online survey, the current study aimed to investigate left‐behind children's emotional and academic adjustment during COVID‐19 pandemic China. The participants included 1780 (960 boys) 1500 non‐left‐behind (811 children elementary junior high school with a mean age of 11.23. Self‐reported questionnaires concerning depression, loneliness, anxiety, adjustment, parents' coping negative emotions were completed. results suggested that...
<h3>Background and Objectives</h3> Multiple reproductive factors are associated with stroke. Little is known about the cumulative effects of during a life course on stroke its subtypes, especially among female Chinese individuals. The objective this study was to assess associations lifetime estrogen exposure due etiologic subtypes postmenopausal women. <h3>Methods</h3> Postmenopausal women without prior at baseline (2004–2008) were selected from China Kadoorie Biobank (CKB). Lifetime...
This study aimed to validate a Chinese's adaption of the Cognitive Emotion Regulation Questionnaire for children (CERQ-Ck). self-report instrument evaluates nine cognitive emotion regulation strategies that can be used by after experiencing negative life event. The CERQ-Ck was evaluated in sample 1403 elementary students between ages 9 and 11 using cluster sampling. All item-correlation coefficients were above 0.30. internal consistencies factors suggested moderate reliability (0.66 0.73)....