A5075460531- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- PI3K/AKT/mTOR signaling in cancer
- Nanoplatforms for cancer theranostics
- Acute Myeloid Leukemia Research
- Plant biochemistry and biosynthesis
- Colorectal Cancer Treatments and Studies
- Advanced Nanomaterials in Catalysis
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Sexual Differentiation and Disorders
- Natural product bioactivities and synthesis
- SARS-CoV-2 and COVID-19 Research
- Neurological Complications and Syndromes
- Central Venous Catheters and Hemodialysis
- Pharmacological Effects of Natural Compounds
- Dermatological and COVID-19 studies
- Dermatology and Skin Diseases
- Pharmaceutical Practices and Patient Outcomes
South China Agricultural University
2025
Union Hospital
2020-2024
Huazhong University of Science and Technology
2019-2024
Donghua University
2023-2024
Queen Mary University of London
2024
Union Hospital
2020-2024
Shanghai University of Traditional Chinese Medicine
2024
Chengdu University of Traditional Chinese Medicine
2020-2023
Yinchuan First People's Hospital
2023
Qingdao University
2023
No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes respiratory Covid-19, and an oxygen saturation (Sao2) 94% or less while they were breathing ambient air ratio partial pressure (Pao2) to fraction inspired (Fio2) than 300 mm Hg. Patients randomly assigned in 1:1 receive either lopinavir-ritonavir...
On March 11, 2020, the World Health Organization declared its assessment of coronavirus disease 2019 (COVID-19) as a global pandemic. However, specific anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) drugs are still under development, and patients managed by multiple complementary treatments. We performed retrospective analysis to compare evaluate effect low molecular weight heparin (LMWH) treatment on progression. For this purpose, clinical records laboratory indicators...
Summary Background On March 11, 2020, the World Health Organization declared its assessment of COVID-19 as a global pandemic. However, specific antiviral drugs are still unavailable, and pateints managed by multiple complementary treatments. Methods The electronic medical records patients where basic information, complete blood count, coagulation profile, inflammatory cytokines serum biochemical indicators in 42 with (21 whom were treated low molecular weight heparin (LMWH), 21 without LMWH)...
Studies have confirmed that Angelica sinensis, which is a famous medicinal food in China, can effectively alleviate the symptoms of ulcerative colitis (UC) rats. However, as major water-soluble ingredient, specific effects A. sinensis polysaccharide (ASP) on UC and potential mechanisms were uncertain. In this study, we aimed to elucidate protective ASP dextran sulfate sodium (DSS)-induced further explore mechanisms. could significantly ameliorate weight loss, disease activity index score,...
Postoperative acute kidney injury (pAKI) is a serious complication of Stanford type A aortic dissection (TAAD) surgery, which significantly associated with the inflammatory response. This study aimed to explore relationship between blood count-derived markers (BCDIMs) and pAKI construct predictive model for pAKI. Patients who underwent TAAD surgery were obtained from our center Medical Information Mart Intensive Care (MIMIC)-IV database. The differences in preoperative BCDIMs clinical...
Abstract Atrial fibrillation (AF) affects 33.5 million individuals worldwide. It accounts for 15% of strokes and increases risk heart failure sudden death. The voltage‐gated cardiac sodium channel complex is responsible the generation conduction action potential, composed main pore‐forming α‐subunit Na v 1.5 (encoded by SCN5A gene) one or more auxiliary β‐subunits, including β1 to β4 encoded SCN1B SCN4B , respectively. We others identified loss‐of‐function mutations in SCN2B...
Tacrolimus is a key drug in kidney transplantation with narrow therapeutic index. However, whether tacrolimus exposure variability affects clinical outcomes and adverse reactions remains unknown.Our study investigated the factors that influence recipients relationship between concentration reactions.We examined effect of on 201 recipients, identified pharmacogenetic explain exposure.The CYP3A5 genotype was clearly associated dose-adjusted trough blood concentrations (C0/D), whereas no...
High-precision temperature sensor is demonstrated based on weak measurement using spectrum domain analysis. By introducing an extra phase to the postselection, operating range and precision can be conveniently modulated. Spectral shifts resulted from variation are robust practical imperfections. The of 2.4 × 10-6°C achieved by a currently available spectrometer. maximum associated with nematic liquid crystals (NLCs) sample. Moreover, sensitivity 16.16 nm/°C obtained experimentally in...
Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.217,19.015,19]henicosane core. Spiropchaeglobosin (2) was the first example of featuring a spiro[5.10]hexadecane unit. Pchaeglobosals (3) and B (4) featured unique 5/5/13 fused tricyclic ring system. Compounds 1–4 tested for their antiproliferative, apoptosis, cell cycle arrest,...
Tacrolimus has unpredictable pharmacokinetic (PK) characteristics, which are partially attributed to CYP3A5 polymorphism. The potential effects of clinical factors in the postoperative period transplantation on tacrolimus PK and those early variability outcomes yet be clarified.We examined genetic affecting 256 kidney transplant recipients. relationships among exposure, graft function delay (DGF), acute rejection (AR) were further explored. Findings. genotype strongly associated with...
Clinical next-generation sequencing (NGS) tests have enabled treatment recommendations for cancer patients with driver gene mutations. Targeted therapy options without mutations are currently unavailable. Herein, we performed NGS and proteomics on 169 formalin-fixed paraffin-embedded (FFPE) samples of non-small cell lung cancers (NSCLC, 65), colorectal (CRC, 61), thyroid carcinomas (THCA, 14), gastric (GC, 2), gastrointestinal stromal tumors (GIST, 11), malignant melanomas (MM, 6). Of the...
Background Fangcang Hospitals (cabin hospitals) played a key role in isolation and control of the infection sources during COVID-19 epidemic. Many patients at had complications or mental stress. As doctors, nurses paramedics presented emergency, there was growing demand for clinical pharmacists to provide pharmaceutical care affected with chronic diseases via telemedicine. Objective This study retrospective evaluate usefulness prevention measures Jianghan Hospital. Besides, this proposed...
Abstract Background Imatinib treatment often produces various adverse reactions in patients with chronic myeloid leukemia (CML), and increasing are pursuing dose optimization. In this study, the authors aimed to explore imatinib optimization based on therapeutic drug monitoring (TDM) CML patients. Methods The relationship between concentration clinical response was evaluated, then dose‐reduction data 110 Chinese also explored. Results Patients a major molecular (MMR) had higher plasma...