A5029647632- Hydrogen's biological and therapeutic effects
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- High Altitude and Hypoxia
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Neonatal and fetal brain pathology
- Neurological Disease Mechanisms and Treatments
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience of respiration and sleep
Tianjin Medical University General Hospital
2016-2025
Tianjin Medical University
2013-2024
The University of Sydney
2024
Sun Yat-sen University
2022-2023
Tianjin Hospital
2014-2023
Tianjin People's Hospital
2020-2022
Weifang Medical University
2020-2021
GTx (United States)
2017-2020
Shanghai Jiao Tong University
2019
Renji Hospital
2019
Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death care units. Excessive production reactive oxygen species plays an important role pathogenesis sepsis. Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, cytotoxic species) effectively protects against organ damage induced I/R. Therefore, we hypothesized H2 treatment...
Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis. MicroRNAs (miRNAs) are class of small non-coding RNAs, approximately 21–25 nucleotides in length. Recently, some researchers have demonstrated that plasma miRNAs sensitive and specific biomarkers various cancers. The primary aim the study to investigate whether present GBM patients can be used as diagnostic associated glioma classification clinical treatment. Plasma samples were attained by venipuncture from...
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our other studies have found that hydrogen gas (H₂) treatment can ameliorate the induced by sepsis, ventilator, hyperoxia, ischemia-reperfusion. However, molecular mechanisms which H₂ ameliorates remain unclear. In current study, we investigated whether or hydrogen-rich saline (HS) could exert protective effects mouse model ALI intratracheal administration lipopolysaccharide...
Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an role normal cardiac homeostasis, and obstructions to process lead severe consequences for heart. Hydrogen exerts effective therapeutic numerous diseases associated with injury via its anti‑inflammation, anti‑apoptosis anti‑oxidative properties. Therefore, present study investigated effect hydrogen on inflammation response apoptosis...
Sepsis/multiple organ dysfunction syndrome is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (•OH, most cytotoxic reactive oxygen species). We have found H2 inhalation significantly improved survival rate and damage septic mice with moderate or severe cecal ligation puncture. In present study, we investigated effects 2% treatment on zymosan...
Abstract Background Chronic neuropathic pain is an intractable with few effective treatments. Moderate cold stimulation can relieve pain, and this may be a novel train of thought for exploring new methods analgesia. Transient receptor potential melastatin 8 (TRPM8) ion channel has been proposed to important molecular sensor cold. Here we investigate the role TRPM8 in mechanism chronic using rat model constriction injury (CCI) sciatic nerve. Results Mechanical allodynia, thermal hyperalgesia...
Selective vasopressin V(1A) receptor agonists may have advantages over arginine in the treatment of septic shock. We compared effects selepressin, a selective agonist, vasopressin, and norepinephrine on hemodynamics, organ function, survival an ovine shock model.
The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related 2 (Nrf2) is a redox-sensitive master switch that regulates expression antioxidant protective enzymes. This study investigated effects 2% H2 on intestinal injuries underlying mechanisms mouse model severe Male Nrf2 knockout mice (Nrf2-KO) wild-type (WT)...
Abstract Recent studies have identified that N 6 -methyladenosine (m A) extensively participates in the myocardial injury pathophysiological process. However, role of m A on sepsis-induced is still unclear. Here, we investigated functions and mechanism methyltransferase METTL3 for septic injury. Results illustrated modification level up-regulated lipopolysaccharide (LPS)-induced cardiomyocytes (H9C2 cells). Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) revealed profile cellular...