A5101711239- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Hydrogen's biological and therapeutic effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiac Ischemia and Reperfusion
- Medical Research and Treatments
- Hemodynamic Monitoring and Therapy
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Dietary Effects on Health
- Tryptophan and brain disorders
- Mycobacterium research and diagnosis
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin D Research Studies
- High Altitude and Hypoxia
- Optical Imaging and Spectroscopy Techniques
Tianjin Medical University General Hospital
2017-2025
Tianjin Hospital
2017-2024
Massachusetts General Hospital
2020-2022
Harvard University
2020-2022
XinHua Hospital
2020
Second Affiliated Hospital of Nanchang University
2020
Nanchang University
2020
Shanghai First Maternity and Infant Hospital
2020
Sun Yat-sen University
2020
Tongji University
2020
Background Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not adult mice. This study tested the hypothesis that differences brain amounts activity of mitochondria–adenosine triphosphate (ATP)–Nuak1–Tau cascade between mice contribute to age-dependent effects sevoflurane on function. Methods 6- 60-day-old both sexes received with 3% for 2 h daily 3 days. Biochemical methods were used measure Tau, phosphorylated Nuak1, ATP concentrations,...
The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related 2 (Nrf2) is a redox-sensitive master switch that regulates expression antioxidant protective enzymes. This study investigated effects 2% H2 on intestinal injuries underlying mechanisms mouse model severe Male Nrf2 knockout mice (Nrf2-KO) wild-type (WT)...
Ischemia-reperfusion (I/R) is a critical pathophysiological basis of cognitive dysfunction caused by ischemia stroke. Heme-oxygenase-1 (HO-1) the rate-limiting enzyme for elimination excessive free heme combining with hemopexin (HPX), plasma protein that contributes to eliminating during This study aimed elucidate whether HPX could alleviate in rats subjected cerebral I/R. Rats were randomly divided into five groups: sham, MCAO, Vehicle, and + protoporphyrin IX (ZnPPIX). Cerebral I/R was...
ABSTRACT Aims Repeated sevoflurane exposure during the neonatal stage may induce Tau phosphorylation, dendritic spine loss, and neurocognitive impairment in developing brain. Tubulin tyrosine ligase like‐6 (TTLL6), which aggregates dendrites due to missorting, regulates microtubule stability via α‐tubulin polyglutamylation. Meanwhile, Spastin modulates formation by severing microtubules. We hypothesize that repeated treatment impairs remodeling mice enhancing TTLL6‐mediated tubulin...
Vitamin D prevents hypocalcaemia, osteoporosis, and infections, among other problems, is involved in the prevention treatment of cardiovascular neurological diseases. Recently, vitamin was shown to improve cognitive dysfunction caused by Alzheimer's disease vascular dementia. This study aims explore correlation between preoperative serum postoperative disorder (POCD) occurrence elderly patients with gastrointestinal tumors guide perioperative medication use promote early patient...
Although the biological relationship between vitamin D (VD) deficiency and cognitive function has been recognized by many scholars, theoretical mechanisms involved are still not well-understood. In this study, we demonstrated role of VD in alleviating dysfunction aged mice caused sevoflurane anesthesia. Forty female C57BL/6 12 months were selected for experiment. (-) (+) mouse models anesthesia established. Mice randomly divided into normal elderly group (NC group), + treatment (NS [VD...
Ischemia-reperfusion (I/R) is a critical pathophysiological change of ischemic stroke. Heme-oxygenase-1 (HO-1) rate-limiting enzyme eliminating excessive free heme by combining with hemopexin (HPX), plasma protein contributing to alleviating infarct size due ischemia This study was investigate whether HPX could improve angiogenesis after cerebral ischemia-reperfusion via up-regulating HO-1. Rats were randomly divided into five groups: sham, MCAO, MCAO + Vehicle, and protoporphyrin IX...
Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits newborn mice not adult mice, whereas short-term single inhalations had little effect on function at both ages. The mechanisms behind these effects, however, are unclear.In current study, 6- and 60-day-old C57bl groups were given 3% plus 60% oxygen for three consecutive...
BACKGROUND: Ketamine is an intravenous anesthetic. However, whether ketamine can induce neurotoxicity and neurobehavioral deficits remains largely unknown. Delirium a syndrome of acute brain dysfunction associated with anesthesia surgery in patients, tau protein may contribute to postoperative delirium. Finally, affect the function endosome, key organelle for release from neurons. Therefore, we set out determine effects on delirium-like behavior mice trafficking cultured cells. METHODS: We...
With an aging population, the incidence of obstructive sleep apnea syndrome (OSAS) is rising, resulting in a growing number patients undergoing surgery who are also affected by OSAS. The combined impact anesthetic drugs and OSAS-related neurological damage has drawn significant attention. Here, wild-type (WT) Tau-knockout (Tau-KO) mice were subjected to intermittent hypoxia sevoflurane exposure induce OSAS sevoflurane-induced neurotoxicity. Protein expression tau phosphorylation...
This study aims to investigate whether androgen deprivation, simulating conditions of aging or disease-induced low testosterone levels, increases the susceptibility male mice sevoflurane neurotoxicity, and supplementation can reverse toxic effects sevoflurane. In here, young were subjected orchiectomy (ORC) induce deprivation. Various techniques, including western blotting, immunofluorescence, Morris Water Maze, Golgi staining, neuronal signal measurement, used evaluate on long-term (ORC 10...
IntroductionCurrent electroencephalogram (EEG) indices for monitoring the depth of anesthesia have not been adjusted age. This study aims to identify most suitable EEG across different age groups.MethodIn here, we conducted a prospective observational trial observe whether features in groups can detect and compare their performance.ResultsIn Group 1, absolute θ had highest prediction probability (Pk) value (0.78 ± 0.07), while relative γ lowest coefficient variation (CV) states 1 (0.160), 2...
Objective To investigate the effect of hemopexin (HPX) on promoting endothelial progenitor cells (EPCs) differentiation and neovascularization to protect integrity from toxic heme through oxygenase-1 (HO-1) pathway. Methods Rat EPCs were cultured routinely, randomly divided into 5 groups (at their logarithmic phase): control group, HPX heme+HPX Zn protoporphyrin IX (ZnppIX) group. Cells in group M199 culture medium with 10% fetal calf serum, μg/mL basic fibroblast growth factor 1%...
Hemopexin (HPX) has the strongest affinity to heme in plasma, which can bind and transfer free hemes. Previous studies have proved that HPX possesses several functions such as antioxidant, anti-apoptosis, immune regulation neuro-protection a variety of disease processes. In recent years, research on protection role cerebrovascular continued making progresses. This article reviewed main physiological function neuronal disease, aimed provide new ideas for clinical use disease. Key words:...
Abstract Background Ketamine is an anesthetic and antidepressant drug. However, whether ketamine can induce neurotoxicity neurobehavioral deficits remains largely unknown. Delirium a syndrome of acute brain dysfunction that very similar to the presentation after administration. The onset postoperative delirium in patients often accompanied by elevated tau cerebrospinal fluid. And may affect endosome, key organelle for release from neurons. Therefore, we set out determine effects on...