A5102853511- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Robotic Path Planning Algorithms
- Biochemical effects in animals
- Advanced Vision and Imaging
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Hydrogen's biological and therapeutic effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Robotics and Sensor-Based Localization
- Clusterin in disease pathology
- Microstructure and mechanical properties
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- Advanced Algorithms and Applications
- Advanced Chemical Sensor Technologies
- Spine and Intervertebral Disc Pathology
- Metaheuristic Optimization Algorithms Research
- Pediatric health and respiratory diseases
- Gas Sensing Nanomaterials and Sensors
- Chronic Obstructive Pulmonary Disease (COPD) Research
Jiangsu Normal University
2008-2024
Central South University
2023-2024
Xiangya Hospital Central South University
2023-2024
Xi'an Jiaotong University
2024
Chengdu Military General Hospital
2011-2023
China University of Mining and Technology
2015-2020
Kunming General Hospital of Chengdu Military Command
2011-2018
Hainan Medical College Hospital
2016
Air Force Medical University
1991-2003
Columbia University
1996
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our other studies have found that hydrogen gas (H₂) treatment can ameliorate the induced by sepsis, ventilator, hyperoxia, ischemia-reperfusion. However, molecular mechanisms which H₂ ameliorates remain unclear. In current study, we investigated whether or hydrogen-rich saline (HS) could exert protective effects mouse model ALI intratracheal administration lipopolysaccharide...
Aim Glycyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In present study, protective effects GL I/R injury, as well related molecular mechanisms, were investigated in rat brains. Methods Focal cerebral was induced intraluminal filamentous occlusion middle artery (MCA) Male Sprague-Dawley rats. alone or rHMGB1 administered intravenously at time reperfusion. Serum levels...
ABSTRACT Endoplasmic reticulum (ER) stress is associated with ischemia/reperfusion (I/R)-induced cardiomyocyte apoptosis. Crocin could protect myocardial cells against I/R injury and suppress ER stress. This study aimed to explore the molecular mechanism of crocin related in injury. We found alleviated I/R-induced apoptosis both primary cardiomyocytes mouse models. The expression Bax, active caspase 3, glucose-regulated protein 78 kDa (GRP78), C/EBP homologous (CHOP) induced by was reduced,...
In contrast to conventional remote sensing images, hyperspectral images are characterized by a greater number of spectral bands and exceptionally high resolution. The richness both spatial information facilitates the precise classification various objects within establishing imaging as indispensable for applications. However, labor-intensive time-consuming process labeling results in limited labeled samples, while challenges like similarity between different variation same object further...
At least 13 genes (mec-1, mec-2, mec-4-10, mec-12, mec-14, mec-15, and mec-18) are needed for the response to gentle touch by 6 receptor neurons in nematode Caenorhabditis elegans. Several, otherwise recessive alleles of some these act as dominant enhancer mutations temperature-sensitive mec-4, mec-5, mec-6, mec-15. Screens additional enhancers mec-4 mec-5 yielded previously known genes. In addition, mec-7 showed allele-specific, suppression mec-15 touch-insensitive (Mec) phenotype. The...
Recent studies suggest that the novel neuropeptide orexin-A may play an essential role during neuronal damage. However, function of brain ischemia remains unclear. Recently, hypoxia-inducible factor-1α (HIF-1α) was shown to be activated by orexin-A. The aim current study is test hypothesis administration exogenous can attenuate ischemia-reperfusion injury through facilitation HIF-1α expression.Sprague-Dawley rats were subjected transient middle cerebral artery occlusion for 120 min. Rats...
Tetramethylpyrazine (TMP) has been widely used in China as a drug for the treatment of various diseases. Recent studies have suggested that TMP protective effect on ischemic neuronal damage. However, exact mechanism is still unclear. This study aims to investigate mediated hippocampal neurons injury induced by oxygen-glucose deprivation (OGD). The viability was detected MTT assay, LDH release assay and apoptosis rate measured flow cytometry. significantly suppressed neuron...
Background Increasing evidence has revealed that humid heat stress (HHS) causes considerable damage to human health. The cardiovascular system been suggested be the primary target of stress, which results in serious diseases. However, there is still a lack effective approaches for prevention and treatment diseases induced by HHS. Objective Heat-shock proteins (Hsps), especially Hsp70, are reported provide cytoprotection under various stimuli. In present study, we evaluated cytoprotective...
Decision tree is an important learning method in machine and data mining ,this paper discusses the of choosing best attribute based on information entropy .It analyzes process characters classification discovery knowledge decision about application .Through instance ,the shows procedure selecting detail ,finally it pointes out developing trends tree.
The silent information regulator SIR2/SIRT1gene has been demonstrated as regulating lifespan in many model organisms, including yeast, worms, fruit flies and rodents. SIRT1, the human homolog of SIR2, is considered a candidate gene modifier life expectancy. In current study we included 616 long-lived individuals 846 matched younger controls to investigate associations between 8 common single nucleotide polymorphisms (SNPs) (i.e., rs12778366, rs3758391, rs3740051, rs33957861, rs7896005,...
Vision Transformers (ViTs) have recently garnered considerable attention, emerging as a promising alternative to convolutional neural networks (CNNs) in several vision-related applications. However, their large model sizes and high computational memory demands hinder deployment, especially on resource-constrained devices. This underscores the necessity of algorithm-hardware co-design specific ViTs, aiming optimize performance by tailoring both algorithmic structure underlying hardware...
Purpose – The purpose of this study satisfied the need for rapid, sensitive and highly portable identification an explosion gas. In our study, a battery-operated, low-cost gas detection system consisting cataluminescence-based sensor array was developed This device shows how discriminatory capacity arrays utilizing pattern recognition operate in environments. Design/methodology/approach A total 25 units, including common metal oxides decorated materials, have been carefully selected as...
Notch signaling, a critical pathway in cell fate determination, is well known to be involved immune and inflammatory reactions, whereas its role acute lung injury (ALI) remains unclear. Here, we report that notch signal activity upregulated tissue harvested from an ALI mouse model (induced by zymosan). We showed was increased 6 h after zymosan injection peaked at 24 h. Inhibition of signaling either pre- or post-zymosan treatment with N-[N-(3,5-difluorophenacetyl)-l-alanyl]-(S)-phenylglycine...
Abstract A gaseous sensor system was developed for the detection of methane based on its cataluminescence emission. Cataluminescence characteristics and optimal conditions were studied in detail under optimized experimental conditions. Results showed that could cover a linear range from 10 to 5800 ppm (R = 0.9963, n 7) limit about 7 (S/N 3), which below standard permitted concentration. Moreover, discriminant analysis method used test recognizable performance sensor. It found methane,...
In the logistics warehouse environment, autonomous navigation and environment perception of sorting robot are two key challenges. To deal with complex obstacles cargo layout in a warehouse, this study focuses on improving system to achieve efficient path planning safe motion control. For purpose, scheme based an improved Gmapping algorithm is proposed construct high-precision map inside through scanning processing environmental data by robots. While effectively integrates sensor position...