A5001630289- Hydrogen's biological and therapeutic effects
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Anesthesia and Sedative Agents
- Pain Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Cardiac, Anesthesia and Surgical Outcomes
- High Altitude and Hypoxia
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Vagus Nerve Stimulation Research
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Neuroscience and Neuropharmacology Research
- Fungal Biology and Applications
- Ferroptosis and cancer prognosis
- Infective Endocarditis Diagnosis and Management
- Eicosanoids and Hypertension Pharmacology
- Traumatic Brain Injury and Neurovascular Disturbances
Tianjin Medical University General Hospital
2016-2025
Shandong University
2008-2025
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Tianjin Medical University
2014-2024
Dalian Medical University
2014-2024
Liaoning University of Traditional Chinese Medicine
2017-2024
Chinese PLA General Hospital
2014-2024
Shanghai Jiao Tong University
2024
XinHua Hospital
2020-2024
Screening and early detection reduces mortality due to colorectal cancer (CRC). Methylated Septin 9 (SEPT9) is a new blood-based biomarker for CRC. We evaluated the performance of second-generation SEPT9 assay neoplasm, compared it with fecal immunochemical test (FIT).A total 135 patients CRC, 169 adenomatous polyps, 81 hyperplastic 91 healthy controls were included. The clinical status all subjects was verified by colonoscopy. In patients, peripheral blood samples taken testing using Epi...
Background Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not adult mice. This study tested the hypothesis that differences brain amounts activity of mitochondria–adenosine triphosphate (ATP)–Nuak1–Tau cascade between mice contribute to age-dependent effects sevoflurane on function. Methods 6- 60-day-old both sexes received with 3% for 2 h daily 3 days. Biochemical methods were used measure Tau, phosphorylated Nuak1, ATP concentrations,...
The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related 2 (Nrf2) is a redox-sensitive master switch that regulates expression antioxidant protective enzymes. This study investigated effects 2% H2 on intestinal injuries underlying mechanisms mouse model severe Male Nrf2 knockout mice (Nrf2-KO) wild-type (WT)...
The blood-brain barrier (BBB) is a protective for brain safety, but it also major obstacle to the delivery of drugs cerebral parenchyma such as hippocampus, hindering treatment central nervous system diseases Alzheimer's disease (AD). In this work, an anti-AD brain-targeted nanodrug by co-loading icariin (ICA) and tanshinone IIA (TSIIA) into Aniopep-2-modified long-circulating (Ang2-ICA/TSIIA) liposomes was developed. Low-density lipoprotein receptor-related protein-1 (LRP1) receptor...
Alzheimer's disease (AD) is a neurodegenerative that associated with aging and influenced by both genetic environmental factors. Several studies clinical trials have demonstrated resveratrol (Res) salidroside (Sal) are not only biologically safe but also influence AD biomarker trajectories. However, their applications been quite limited due to poor specificity, low solubility, insufficient blood-brain barrier (BBB) penetration. Therefore, we developed nano-drug delivery system in which Res...
Background: Invasive pneumococcal disease (IPD, Streptococcus pneumoniae) has been a nationally notifiable in Canada since 2000.The use of conjugate vaccines caused shift the distribution serotypes over time.This report is summary demographics, and antimicrobial resistance IPD isolates collected 2021 2022.Methods: The National Microbiology Laboratory (NML) Public Health Agency Winnipeg, Manitoba collaborates with provincial territorial public health laboratories to conduct national...
Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase risk ovarian malignancy and play an important role in carcinogenesis. Our previous studies showed that increases expression VEGF through survivin. In this study, function mechanism were further explored. We found promoted proliferation prevented apoptosis cells by activating survivin SAPK/JNK PI3K/AKT pathways. also down-regulated programmed cell gene 6 (PDCD6) receptor 5 (DR5), two...
Chemotherapy-induced neuropathic pain (CINP) is one of the most common complications chemotherapeutic drugs which limits dose and duration potentially life-saving anticancer treatment compromises quality life patients. Our previous studies have reported that molecular hydrogen (H2) can be used to prevent treat various diseases. But underlying mechanism remains unclear. The aim present study was explore effects hydrogen-rich water on gut microbiota in CINP.All C57BL/6J mice were divided into...
Sepsis-induced lung injury is an acute hypoxic respiratory insufficiency caused by systemic infectious factors that results in alveolar epithelial cell and capillary endothelial injury, diffuse pulmonary interstitial edema, edema. Heme oxygenase (HO)-1 usually associated with inflammation has anti-inflammatory effects. Autophagy a degradation pathway eliminates cellular metabolic waste plays important protective role during stress. The phosphatidylinositol 3-kinase/ protein kinase B...
The gammaproteobacterium Shewanella oneidensis MR-1 utilizes a complex electron transfer network composed primarily of c-type cytochromes to respire under anoxic conditions variety compounds, including fumarate, nitrate, and dimethyl sulfoxide (DMSO), in addition the minerals Fe(III) Mn(IV). Central several respiratory pathways is CymA, cytoplasmic membrane-bound tetraheme cytochrome that functions as major hydroquinone dehydrogenase. To investigate functional redundancy plasticity S....