A5001382132- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Gut microbiota and health
- Anesthesia and Pain Management
- Tryptophan and brain disorders
- Health and Medical Research Impacts
- S100 Proteins and Annexins
- Cardiac Ischemia and Reperfusion
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Enhanced Recovery After Surgery
- Cellular transport and secretion
- ATP Synthase and ATPases Research
- Airway Management and Intubation Techniques
- Pain Mechanisms and Treatments
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Wenzhou Medical University
2025
Guangdong Medical College
2025
GTx (United States)
2024
Pain and Rehabilitation Medicine
2020-2024
Yale University
2023
Athinoula A. Martinos Center for Biomedical Imaging
2023
Beth Israel Deaconess Medical Center
2019-2022
Tianjin Medical University General Hospital
2020
Background: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are increased risk of cognitive impairment.The authors therefore established animal model single versus anesthetic(s) in young adult mice, aiming distinguish the role different types impairment.Methods: Six-and 60-day-old mice were exposed various regimens.The then determined effects on learning memory function, levels proinflammatory cytokine interleukin-6...
Abstract Objective An estimated 200 million patients worldwide have surgery each year. Anesthesia and been reported to facilitate emergence of Alzheimer's disease. The commonly used inhalation anesthetic isoflurane has previously induce apoptosis, increase levels aggregation disease–associated amyloid β‐protein (Aβ) in cultured cells. However, the vivo relevance not addressed. Methods We therefore set out determine effects on caspase activation β‐site precursor protein–cleaving enzyme (BACE)...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Postoperative delirium and postoperative cognitive dysfunction share risk factors may co-occur, but their relationship is not well established. The primary goals of this study were to describe the prevalence investigate its association with in-hospital delirium. authors hypothesized that would be a significant factor for during follow-up. Methods used data from an observational...
Blood-brain barrier (BBB) dysfunction, e.g., increase in BBB permeability, has been reported to contribute cognitive impairment. However, the effects of anesthesia and surgery on underlying mechanisms, associated function remain largely be determined. Here, we assessed (laparotomy) under 1.4% isoflurane (anesthesia/surgery) for 2 h levels junction proteins both 9- 18-month-old wild-type mice 9-month-old interleukin (IL)-6 knockout mice. permeability was determined by dextran tracer...
The common inhalation anesthetic isoflurane has previously been reported to enhance the aggregation and cytotoxicity of Alzheimer disease-associated amyloid beta protein (Abeta), principal peptide component cerebral beta-amyloid deposits.H4 human neuroglioma cells stably transfected express full-length wild-type precursor (APP) were exposed 2% for 6 h. conditioned media harvested at end treatment. Caspase-3 activation, processing APP, cell viability, Abeta levels measured with quantitative...
<h3>Objective</h3> To assess the effects of sevoflurane, most commonly used inhalation anesthetic, on apoptosis and β-amyloid protein (Aβ) levels in vitro vivo. <h3>Subjects</h3> Naive mice, H4 human neuroglioma cells, cells stably transfected to express full-length amyloid precursor protein. <h3>Interventions</h3> Human were exposed 4.1% sevoflurane for 6 hours. Mice received 2.5% 2 Caspase-3 activation, apoptosis, Aβ assessed. <h3>Results</h3> Sevoflurane induced elevated β-site...
The anesthetic isoflurane has been reported to induce apoptosis and increase Aβ generation aggregation. However, the molecular mechanism underlying these effects remains unknown. We therefore set out assess whether of on are linked amyloid β-protein (Aβ) For this purpose, we assessed β-site β precursor protein (APP)-cleaving enzyme (BACE) γ-secretase, proteases responsible for generation. also tested inhibitors aggregation (iAβ5, a β-sheet breaker peptide; clioquinol, copper–zinc chelator)...
The common inhalation anesthetic isoflurane has been shown to induce apoptosis, which then leads accumulation of beta-amyloid protein, the hallmark feature Alzheimer disease neuropathogenesis. underlying molecular mechanism isoflurane-induced apoptosis is largely unknown. We, therefore, set out assess whether can by regulating Bcl-2 family proteins, enhancing reactive oxygen species (ROS) accumulation, and activating mitochondrial pathway apoptosis. We performed these studies in cultured...
ANESTHESIA neurotoxicity in the developing brain has been investigated animals and humans become a major health issue of interest to both medical community1and public.2Anesthesia surgery may induce neurodevelopmental impairment cognitive dysfunction children (reviewed Sun3). In preclinical studies, anesthesia shown learning memory young animals4(reviewed Creeley Olney5).Each year, over 75,000 pregnant women United States have nonobstetric fetal intervention procedures under...
Background Recent studies have suggested that children undergoing surgery under anesthesia could be at an increased risk for the development of learning disabilities, but whether anesthetics contribute to this disability is unclear. Therefore, authors set out assess effects sevoflurane, most commonly used inhalation anesthetic, on caspase activation, apoptosis, beta-amyloid protein levels, and neuroinflammation in brain tissues neonatal naïve Alzheimer disease (AD) transgenic mice. Methods...
Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane is a commonly used anesthetic in children. Tau phosphorylation contributes dysfunction. The authors therefore assessed the effects sevoflurane on underlying mechanisms young mice.
Abstract Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out employ a battery behavior tests, including natural learned behavior, in mice determine the effects laparotomy under isoflurane anesthesia (Anesthesia/Surgery) on these behaviors. The were tested at 24 hours before 6, 9 after Anesthesia/Surgery. Composite Z scores calculated....
Preclinical evidence suggests that commonly used anesthetic agents induce long-lasting neurobehavioral changes when administered early in life, but there has been virtually no attention to the neurodevelopmental consequences for fetus of maternal anesthesia. This study tested hypothesis fetal rats exposed isoflurane during anesthesia on gestational day 14, which corresponds second trimester humans, would be behaviorally abnormal as adults.Timed, pregnant were randomly assigned 14 receive...
BACKGROUND: Preexisting cognitive impairment is emerging as a predictor of poor postoperative outcomes in seniors. We hypothesized that preoperative screening can be performed busy preadmission evaluation center and prevalent elective geriatric surgical patients. METHODS: approached 311 patients aged 65 years older presenting for before surgery prospective, observational, single-center study. Forty-eight were ineligible, 63 declined. The remaining 200 randomly assigned to the Mini-Cog ( N...