A5064986924- Airway Management and Intubation Techniques
- Mitochondrial Function and Pathology
- Tracheal and airway disorders
- Central Venous Catheters and Hemodialysis
- Vitamin C and Antioxidants Research
- Cardiac, Anesthesia and Surgical Outcomes
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Trauma Management and Diagnosis
- Respiratory Support and Mechanisms
- Exercise and Physiological Responses
- Coenzyme Q10 studies and effects
- Thermal Regulation in Medicine
- Simulation-Based Education in Healthcare
- Burn Injury Management and Outcomes
- Blood transfusion and management
- Anesthesia and Neurotoxicity Research
- ATP Synthase and ATPases Research
- Cardiac and Coronary Surgery Techniques
- Anesthesia and Pain Management
- Sirtuins and Resveratrol in Medicine
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cancer, Hypoxia, and Metabolism
- Ultrasound in Clinical Applications
- Venous Thromboembolism Diagnosis and Management
Kyorin University
2012-2025
Weatherford College
2020-2023
Shriners Hospitals for Children - Boston
2016-2022
Harvard University
2014-2022
Massachusetts General Hospital
2014-2022
Shriners Hospitals for Children - Erie
2014-2016
The University of Tokyo
2009
Japanese Red Cross Society, Japan
2009
Aichi Medical University
2009
Hoshi University
2008
To compare changes in vitamin D status and cathelicidin (LL-37) levels septic ICU patients treated with placebo versus cholecalciferol.Randomized, placebo-controlled, trial.Medical surgical ICUs of a single teaching hospital Boston, MA.Thirty adult patients.Placebo (n = 10) 200,000 IU cholecalciferol 400,000 10), within 24 hours new-onset severe sepsis or shock.Blood samples were obtained at baseline (day 1) on days 3, 5, 7, to assess total 25-hydroxyvitamin D, as well D-binding protein...
S-nitrosylation of the deacetylase SIRT1 functions as a proinflammatory switch in aging and inflammatory disorders.
Abstract Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out employ a battery behavior tests, including natural learned behavior, in mice determine the effects laparotomy under isoflurane anesthesia (Anesthesia/Surgery) on these behaviors. The were tested at 24 hours before 6, 9 after Anesthesia/Surgery. Composite Z scores calculated....
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, play a pivotal role insulin resistance wasting. We others have shown that inducible nitric oxide synthase (iNOS), mediator of inflammation, plays an important stress (e.g., burn)-induced resistance. However, it remains to be determined how iNOS induces Moreover, the interrelation between inflammatory response is poorly understood, although they often simultaneously. Nuclear factor (NF)-κB p53 are...
We have implemented several preventive measures to reduce central line-associated bloodstream infection (CLABSI) in the general intensive care unit (ICU) of a university hospital Japan. Here, we analyzed factors associated with CLABSI patients venous catheter (CVC) insertions and evaluated effects our measures. From July 2013 June 2018, data was collected from medical records 1472 1635 CVC insertions, including age, sex, Acute Physiology Chronic Health Evaluation II (APACHE II) score,...
Cricothyroidotomy is a key technique for securing airways when tracheal intubation and oxygenation are difficult to achieve. In recent years, it has become clear that ultrasonography more accurate than palpation identifying the cricothyroid membrane. However, unclear how ultrasound should be administered. We investigated whether real-time or static techniques were useful needle cricothyrotomy in patients with simulated anatomical abnormalities of neck. Three cervical simulators created....
To reduce the risk of transfusion-related acute lung injury (TRALI), plasma products are mainly made from male donors in some countries because lower possibility alloimmunization; other considering this policy. The advantage male-only fresh-frozen (FFP) should be examined a prospective case-control study.This study compared pulmonary function after transfusion FFP derived either only (FFP-male) or mixed (FFP-mixed) informed surgical patients treated at tertiary university hospital Japan....
Mitochondrial dysfunction is associated with metabolic alterations in various disease states, including major trauma (e.g., burn injury). Metabolic derangements, muscle insulin resistance and hyperlactatemia, are a clinically significant complication of trauma. Coenzyme Q10 (CoQ10) an essential cofactor for mitochondrial electron transport, its reduced form acts as lipophilic antioxidant. Here, we report that injury induces impaired signaling, (as indicated by suppressed oxygen consumption...
The aggressiveness of triple-negative breast cancer (TNBC), which lacks estrogen receptor, progesterone receptor and epidermal growth factor 2 (HER2), represents a major challenge in cancer. Migratory self-renewal capabilities are integral components invasion, metastasis recurrence TNBC. Elevated hypoxia-inducible factor-1α (HIF-1α) expression is associated with Nonetheless, how HIF-1α regulated induces aggressive phenotype not completely understood cytotoxic effects farnesyltransferase...
Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction hyperlactatemia. Nonetheless, the molecular pathogenesis relation between these diverse metabolic alterations poorly understood. We have previously shown that increases farnesyltransferase (FTase) expression protein farnesylation FTase inhibitor (FTI) prevents burn-induced...
Objective Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of trauma (e.g., burn injury) affect the prognosis patients. Protein farnesylation, posttranslational lipid modification cysteine residues, has been emerging as potential component inflammatory response in sepsis. However, farnesylation not yet studied trauma. To study role burn-induced metabolic aberration, we examined effects farnesyltransferase (FTase) inhibitor, FTI-277, on...
Abstract Background: A high-fidelity task simulator for cricothyroidotomy was created using data from a 3-dimensional (3D) computed tomography scan 3D printer. We hypothesized that this results in increased proficiency needle compared with conventional simulators. Methods: Cricothyroidotomy-naive residents were recruited and randomly assigned to 2 groups, including simulation training (Group C) 3D). After training, participants performed an ex vivo porcine larynx fitted endoscope record the...
SUMMARY Objectives To construct an alternative policy for the donor selection of platelet concentrate ( PC ), a clinical study exploring features lung injury following administration is needed. Background Although male‐donor‐only plasma products appears to have efficiently reduced transfusion‐related acute TRALI this may not be applied because supply shortages. Methods and Materials We prospectively examined pulmonary function after transfusion in informed surgical patients treated at...
Mitochondrial dysfunction has been implicated in the pathogenesis of inflammation and multi-organ major trauma, including burn injury. Coenzyme Q10 (CoQ10) is a metabolite mevalonate pathway an essential cofactor for electron transport mitochondria. In addition, its reduced form (ubiquinol) functions as antioxidant. Little known to whether oral CoQ10 supplementation effectively increases intracellular levels humans. To study bioavailability supplementation, we conducted randomized,...
Methandienone, methandriol, and oxymetholone, which are anabolic steroids possessing 17alpha-methyl 17beta-hydroxy groups, were developed as oral formulations for therapeutic purposes. However, they have been used in racehorses to enhance racing performance. In humans, it has reported that structurally related having the including 17alpha-methyltestosterone, mestanolone, methandienone, metabolites common. this study, we found common those of 17alpha-methyltestosterone mestanolone detected...
Abstract Rationale: Anti- N -methyl- D -aspartate (NMDA) receptor encephalitis is an immune-mediated syndrome caused by the production of antibodies against NMDA receptors. As receptors are important targets many anesthetic drugs, perioperative management patients with anti-NMDA challenging for anesthesiologists. Patient concerns: A 31-year-old woman presented akinesia and aphasia, which worsened despite steroid therapy. Diagnosis: Anti-NMDA associated ovarian teratoma. Interventions:...
We developed a novel technology using the photoacoustic effect that improve needle tip visibility. evaluated whether this improves visibility when performing deep peripheral nerve block in cadaver model. A was conventional echogenic with an intraluminal optical fiber. pulsed laser sends light from source through fiber, which is converted to ultrasound at effect. expert performed blocks and views recorded, or without tip. Needle by questionnaire (Likert scale 1: very poor, 5: good) completed...
Burn injury remains a significant public health issue worldwide. Metabolic derangements are major complication of burn and negatively affect the clinical outcomes severely burned patients. These metabolic aberrations include muscle wasting, hypermetabolism, hyperglycemia, hyperlactatemia, insulin resistance, mitochondrial dysfunction. However, little is known about impact on metabolome profile in skeletal muscle. We have previously shown that farnesyltransferase inhibitor (FTI) reverses...
Sepsis remains a leading cause of mortality in critically ill patients and is characterized by multi-organ dysfunction. Mitochondrial damage has been proposed to be involved the pathophysiology sepsis. In addition metabolic impairments resulting from mitochondrial dysfunction, DNA (mtDNA) causes systemic inflammation as damage-associated molecular pattern when it released circulation. Metabolic derangements skeletal muscle are major complication sepsis negatively affects clinical outcomes...
Background: Difficult peripheral venous access, especially in obese people, is challenging for novices. We conducted a randomized cross-over study to examine whether near-infrared imaging or ultrasound guidance more useful novice operators obtain difficult access. Methods: Medical students were recruited as participants. After receiving basic training using commercial simulators, participants randomly assigned simulated access simulator with design. A was newly developed deep and narrow...
Highly active antiretroviral therapy (HAART) has successfully reduced the mortality rate of patients with human immune deficiency virus (HIV) and HIV protease inhibitors (HIV PIs) are key components HAART. Complications HAART, particularly those associated PIs including lipodystrophy metabolic disturbance, have emerged as an important public health issue. No specific treatment is available to prevent and/or treat PI-associated syndrome. The present study demonstrated that a relatively...
Abstract Background: Cricothyroidotomy is the final strategy in “cannot intubate, cannot oxygenate” scenario, but half of needle cricothyroidotomy attempts result failure. The most frequent complication posterior tracheal wall injury. We hypothesized that length related to injury and compared with a commercial kit modified shorter evaluate success rates. Methods: has stopper prevent injury, penetrating 25 mm. made long shorten by 5 mm (net 20 length). Residents were recruited, received...