A5044655582- Asymmetric Synthesis and Catalysis
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Cardiac Arrhythmias and Treatments
- Cyclopropane Reaction Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Anesthesia and Pain Management
- Sinusitis and nasal conditions
- Abdominal vascular conditions and treatments
- Crystallography and molecular interactions
- Colorectal Cancer Treatments and Studies
- Organometallic Complex Synthesis and Catalysis
- Ferroptosis and cancer prognosis
- Alkaloids: synthesis and pharmacology
- Spinal Hematomas and Complications
- Liver Disease and Transplantation
- Amyotrophic Lateral Sclerosis Research
- Esophageal and GI Pathology
- Neurological diseases and metabolism
- Restraint-Related Deaths
- Cardiac Ischemia and Reperfusion
- Takotsubo Cardiomyopathy and Associated Phenomena
- Wnt/β-catenin signaling in development and cancer
- Cardiac electrophysiology and arrhythmias
Mie University
2019-2020
Mie University Hospital
2019
Saga University
2017
National Hospital Organization
2016
Fujisawa City Hospital
2016
Yamato Municipal Hospital
2015
Yokohama City University
2003-2014
Harvard University
2008-2014
Shriners Hospitals for Children - Erie
2014
Massachusetts General Hospital
2008-2014
S-nitrosylation of the deacetylase SIRT1 functions as a proinflammatory switch in aging and inflammatory disorders.
Myocardial depression is an important contributor to morbidity and mortality in septic patients. Nitric oxide (NO) plays role the development of cardiomyopathy, but also has protective effects. Recent evidence indicated that NO exerts many its downstream effects on cardiovascular system via protein S-nitrosylation, which negatively regulated by S-nitrosoglutathione reductase (GSNOR), enzyme promoting denitrosylation. We tested hypothesis reducing cardiomyocyte S-nitrosylation increasing...
Cell polarity depends on extrinsic spatial cues and intrinsic proteins including PAR-aPKC proteins. In mammalian epithelial cells, cell-cell contacts provide that activate the aPKC-PAR-3-PAR-6 complex to establish landmark of initial cellular asymmetry. PAR-1, a downstream target complex, mediates further development apical basolateral membrane domains. However, relationships between other provided by extracellular matrix (ECM) remain unclear. Here, we show PAR-1 colocalizes with laminin...
Colorectal cancer is one of the most common causes death worldwide. Using cDNA microarray containing 23 040 genes, we earlier investigated gene-expression profiles in 11 colorectal cancers for purpose better understanding carcinogenesis as well development novel diagnostic and therapeutic strategies. MRG-binding protein (MRGBP) or C20orf20, encoding a subunit TRRAP/TIP60-containing histone acetyltransferase complex, was up-regulated majority tumours. The elevated expression MRGBP observed...
Abstract The syntheses of the marine sponge‐derived γ‐amino carboxylic acid dysibetaine CPa and five analogs in their racemic forms were successfully performed by taking advantage an electron‐withdrawing N ‐(4‐nitrophenyl) group cyclopropanation reaction, reductive ring opening imide, ethanolysis ‐Boc‐protected imide.
MRGBP (MORF4‐related gene‐binding protein; also known as chromosome 20 open reading frame 20) encodes a subunit of the transformation/transcription domain‐associated protein (TRRAP)/tat‐interacting 60 (TIP60)‐containing histone acetyltransferase complex. We previously showed that was upregulated in majority colorectal tumors, and enhanced expression associated with cell proliferation. In this study, we investigated its role carcinogenesis searched for genes regulated by MRGBP....
M. Sakai, H. Yamaguuchi and S. Masamune, J. Chem. Soc. D, 1971, 486 DOI: 10.1039/C29710000486
Sinus tachycardia coupled with high-dose catecholamine is common after cardiopulmonary bypass (CPB). The present study assessed the hemodynamic efficacy and safety of combination therapy using low-dose β1-selective adrenergic blocker (landiolol) inotropes. This was a retrospective, single center, self-comparison at post-anesthesia care unit within tertiary center. included adults who underwent cardiac surgery CPB received landiolol between April 2007 November 2011. We data prior to 1 h...
Objectives To describe the prevalence and factors associated with preoperative haemostasis ABO blood typing tests for children because these might represent low-value care. Design A retrospective observational study. Setting Nationwide insurance claims database in Japan. Participants Patients aged 1–17 years who underwent common non-cardiac surgeries between April 2012 March 2018 were included. high-risk comorbidities bleeding (n=175) those multiple eligible excluded (n=2121). Main outcome...
Intensivists are expected to have many roles during and after a major disaster/catastrophe; that is, triage, intensive care, education for people, so forth. The of intensivists against special disaster or nuclear studied based on actual experiences.
Ruptured aneurysms of the pancreaticoduodenal artery result in fatal hemorrhage and high mortality. Therefore, prompt diagnosis treatment are required, but there sometimes problems differentiating this specific from other abdominal pathologies.We encountered a rare case ruptured aneurysm with an atypical clinical presentation that simulated acute pancreatitis. A 71-year-old woman was admitted to emergency department pain left upper quadrant, slightly elevated level pancreatic amylase,...
Abstract The synthetic efforts to dysibetaine CPb, isolated from Micronesian marine sponge, amenable analog synthesis are reported. Cyclopropane was constructed by a sulfonium ylide-mediated reaction and enantioselective desymmetrization performed methanolysis mediated quinine derivative. (+)-N-(Desmethyl)dysibetaine CPb finally synthesized in 0.37% yield total 14 steps. This is the first of analog.
Abstract The total syntheses of (‐)‐(I), isolated from Lendenfeldia chondrodes, and its antipode render possible the unambiguous determination absolute configuration.
Abstract the absolute configuration of natural product dysibetaine (I) is determined as (3R,4R)
Malignant hyperthermia (MH) is a rare but potentially fatal complication that may develop under general anesthesia (GA) and rarely reported in elderly patients. We encountered case of mild-onset MH 70-year-old patient who was receiving an elective thoracoscopic pulmorrhaphy had history several GA procedures. Anesthesia induced with propofol, fentanyl, rocuronium maintained sevoflurane remifentanil. His body temperature (BT) 37.9°C after induction. During the procedure, end-tidal CO2 (ETCO2)...
Summary A 67‐year‐old, otherwise healthy female, developed recurrent syncope and ventricular asystole immediately after an uncomplicated total knee arthroplasty. The was preceded by postoperative nausea vomiting. ECG findings during these episodes revealed high‐degree atrioventricular block followed pauses, making it impossible to rule out a serious conduction abnormality. Further electrophysiological evaluation that the cardiac conducting system normal. Vagal dependence could not be...