A5065576590- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Foreign Body Medical Cases
- Neonatal Respiratory Health Research
- Pediatric Pain Management Techniques
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Cardiac Ischemia and Reperfusion
- Intracranial Aneurysms: Treatment and Complications
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Anesthesia and Pain Management
- Acute Ischemic Stroke Management
- Trauma and Emergency Care Studies
- Biomedical and Chemical Research
- Obstructive Sleep Apnea Research
Columbia University
2017-2024
Columbia University Irving Medical Center
2019-2024
Texas Health Dallas
2022
New York Hospital Queens
2017-2021
NewYork–Presbyterian Hospital
2017-2021
Oregon Health & Science University
2009-2018
Oregon National Primate Research Center
2013-2017
Presbyterian Hospital
2017
University of Iowa
2015-2016
University of Michigan
2012-2016
Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent brain, but susceptibility of non-human primates to apoptogenic action has not been studied. Therefore, we exposed postnatal day 6 (P6) rhesus macaques a surgical plane for 5 h, and studied brains 3 h later histopathologic changes.With same intensity physiologic monitoring typical human neonatal anesthesia, five P6 were maintained between 0.7 1.5 end-tidal Vol% (endotracheally intubated mechanically ventilated)...
Exposure of rhesus macaque fetuses for 24 h or neonates 9 to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study clarifies minimum exposure required and extent spatial distribution ketamine-induced neonates.Ketamine was administered by IV infusion 5 postnatal day 6 pregnant females at 120 days' gestation (full term = 165 days). Three hours later, were delivered cesarean section, fetal neonatal brains studied evidence apoptotic neurodegeneration, as determined...
Introduction The Glidescope video laryngoscope has been shown to be a useful tool improve laryngeal view. However, its role in the daily routine of airway management remains poorly characterized. Methods This investigation evaluated use at two academic medical centers. Electronic records from 71,570 intubations were reviewed, and 2,004 cases identified where was used for management. We analyzed success rate intubation various scenarios. In addition, incidence character complications...
Video laryngoscopy may be useful in the setting of difficult airway, but it remains unclear if intubation success is improved routine airway management. This study compared rates for tracheal with C-MAC® video laryngoscope (Karl Storz, Tuttlingen, Germany) conventional direct patients predicted airway.We conducted a two arm, single-blinded randomized controlled trial that involved 300 patients. Inclusion required at least one four predictors intubation. The primary outcome was successful on...
Previously we reported that exposure of 6-day-old (P6) rhesus macaques to isoflurane for 5 hours triggers a robust neuroapoptosis response in developing brain. We have also observed (unpublished data) causes apoptosis cellular profiles the white matter resemble glia. analyzed identity apoptotic and determined magnitude this cell death isoflurane.Neonatal were exposed anesthesia according current clinical standards pediatric anesthesia. Brains collected 3 later examined immunohistochemically...
Abstract Background: The authors have previously shown that exposure of the neonatal nonhuman primate (NHP) brain to isoflurane for 5 h causes widespread acute apoptotic degeneration neurons and oligodendrocyte. current study explored potential apoptogenic action in fetal NHP brain. Methods: Fetal rhesus macaques at gestational age 120 days (G120) were exposed utero anesthesia (n = 5) or no (control condition; n 4), all regions systematically evaluated 3 later evidence glia. Results:...
The neonatal striatum degenerates after hypoxia-ischemia (H-I). We tested the hypothesis that damage to astrocytes and loss of glutamate transporters accompany striatal neurodegeneration H-I. Newborn piglets were subjected 30 minutes hypoxia (arterial O2 saturation, 30%) then 7 airway occlusion (O2 5%), producing cardiac arrest, followed by cardiopulmonary resuscitation. Piglets recovered for 24, 48, or 96 hours. At 24 hours, 66% putaminal neurons injured, without differing significantly...
Experimental evidence correlates anesthetic exposure during early development with neuronal and glial injury death, as well behavioral cognitive impairments, in young animals. Several, although not all, retrospective human studies of neurocognitive disorders after childhood to anesthesia suggest a similar association. Few have specifically investigated the effects infant on subsequent neurobehavioral development. Using highly translational nonhuman primate model, authors potential...
Multiple attempts at tracheal intubation are associated with mortality, and successful rescue requires a structured plan. However, there remains paucity of data to guide the choice technique after failed initial direct laryngoscopy. The authors studied large perioperative database determine success rates for commonly used techniques.Using retrospective, observational, comparative design, analyzed records from seven academic centers within Multicenter Perioperative Outcomes Group between 2004...
Cerebral hypoxia-ischemia causes encephalopathy and neurologic disabilities in newborns by unclear mechanisms. We tested the hypothesis that brain damage is system-preferential related to regional oxidative metabolism. One-week-old piglets were subjected 30 minutes of hypoxia then seven airway occlusion, producing asphyxic cardiac arrest, followed cardiopulmonary resuscitation four-day recovery. Brain injury hypoxic-ischemic (n = 6) compared controls 5) was analyzed hematoxylin-eosin, Nissl,...
In Brief BACKGROUND: Intubation success in patients with predicted difficult airways is improved by video laryngoscopy. particular, acute-angle laryngoscopes are now frequently chosen for endotracheal intubation these patients. However, there no evidence concerning whether different can be used interchangeably this scenario and would allow the same rate. We therefore tested first-attempt similar when using a newly introduced blade, that an element of extended airway management system (C-MAC...
The mechanisms for neurodegeneration after hypoxia-ischemia (HI) in newborns are not understood. We tested the hypothesis that striatal neuron death is necrosis and evolves with oxidative stress selective organelle damage. Piglets (∼1 week old) were used a model of hypoxia-asphyxia survived 3, 6, 12, or 24 h. Neuronal was progressive over 3–24 h recovery, ∼80% putaminal neurons dead at Striatal DNA digested randomly 6–12 Ultrastructurally, dying necrotic. Damage to Golgi apparatus rough...
Departments of *Anesthesiology and Perioperative Medicine †Public Health Preventive Medicine, Oregon Science University, Portland, OR.