A5077875021- Intensive Care Unit Cognitive Disorders
- Pelvic floor disorders treatments
- Anesthesia and Neurotoxicity Research
- Synthetic Organic Chemistry Methods
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Global Health and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Mass Spectrometry Techniques and Applications
- biodegradable polymer synthesis and properties
- Hernia repair and management
- Organic Chemistry Cycloaddition Reactions
- Oxidative Organic Chemistry Reactions
- Synthesis of β-Lactam Compounds
- Emergency and Acute Care Studies
- Botulinum Toxin and Related Neurological Disorders
- Infant Nutrition and Health
- Attention Deficit Hyperactivity Disorder
- Cardiovascular Health and Risk Factors
- Chemical Synthesis and Analysis
- Urinary Bladder and Prostate Research
- Anesthesia and Sedative Agents
Indiana University
2025
Mount Auburn Hospital
2022-2025
Indiana University Bloomington
2016-2025
Harvard University
2012-2022
Hadassah Medical Center
2022
Massachusetts General Hospital
2012-2014
Tufts University
2014
Bowdoin College
2013
Western Kentucky University
2012
Eli Lilly (United States)
2011-2012
Studies have described a highly convergent plan toward the synthesis of leiodolide A (1), potent cytotoxic sponge metabolite. The enantiocontrolled preparation aldehyde 6 is achieved with application several advances in methodology for substituted 1,3-oxazoles. Efforts examined halogen dance reaction, selectivity Stille cross coupling reactions 4-bromo-1,3-oxazoles, and nucleophilic displacement 2-phenylsulfonyl substituent organolithium reagents as preparatively useful reactions. These...
The objective of this study was to examine the impact co-occurring social and emotional difficulties on missed school days healthcare utilization among children with attention deficit/hyperactivity disorder (ADHD). Data were from 2007 U.S. National Health Interview Survey (NHIS) based parental proxy responses questions in Sample Child Core, which includes demographics, health, treatment, status as measured by about depression, anxiety, phobias, well items brief version Strength Difficulties...
The neuropathogenesis of postoperative delirium remains unknown. Low cerebrospinal fluid (CSF) βamyloid protein (Aβ) and high CSF Tau levels are associated with Alzheimer's disease. We therefore assessed whether lower preoperative Aβ/Tau ratio was higher incidence greater severity delirium.One hundred fifty three participants (71±5 years, 53% males) who had total hip/knee replacement under spinal anesthesia were enrolled. obtained during initiation anesthesia. determined by Confusion...
Determination of biomarker and neuropathogenesis postoperative cognitive change (POCC) or dysfunction.POCC is one the most common complications in elderly patients. Whether preoperative cerebrospinal fluid (CSF) β-amyloid protein (Aβ) to tau ratio, an Alzheimer disease biomarker, a for risk POCC remains unknown. We therefore set out assess association between CSF Aβ42 Aβ40 ratio POCC.Patients who had total hip/knee replacement were enrolled. The was obtained during administration spinal...
A convergent route toward the synthesis of leiodolide (1) is described. Our studies explored reactions indium chloride-induced transmetalation allylic stannane 32 for nucleophilic addition with nonracemic aldehyde 15. The stereoselective formation all-syn stereotriad was rationalized by an in situ isomerization to produce Z-allylindium reagent subsequent anti-Felkin addition. inversion C17 stereochemistry led effective π-allyl Stille cross coupling utilizing Z-alkenylstannane 11b....
With a decline of infant mortality rates, neonatal rates are striking high in development countries particularly sub Saharan Africa. The toolkit for quality services describes the principle patient satisfaction, which we translate as mother's involvement care and so better outcomes. aim study was to assess mothers' experiences, perception satisfaction hospitals Kilimanjaro region Tanzania. A cross sectional using qualitative quantitative approaches 112 semi structured interviews from 14...
Studies describe formation of the lithium enolate N-(4-methoxybenzyloxy)azetidin-2-one (1) and characterization representative aldol reactions with aldehydes ketones. Diastereoselectivity features production anti-aldol adducts from α,β-unsaturated ketones α-branched aliphatic aldehydes. The stereoselectivity is rationalized via closed, six-membered transition-state arrangements leading to Felkin-Anh anti-Felkin products. Examples illustrate direct incorporation monocyclic β-lactams into a...
Charge tagging is a peptide derivatization process that commonly localizes positive charge on the N-terminus. Upon low energy activation (e.g., collision-induced dissociation or post-source decay) of tagged peptides, relatively few fragment ions are produced due to absence mobile protons. In contrast, high fragmentation, such as 157 nm photodissociation, typically leads series a-type ions. Disadvantages existing tags they can produce protons undesirably large and bulky. Here, we investigate...
There is a higher neonatal mortality rate while the adherence to existing guidelines rarely studied in Tanzania.The aim of this study assess performance health workers for health-care.Settings - Peripheral facilities (regional referral, district hospitals and centers) tertiary referral hospital Kilimanjaro region, Tanzania. Fourteen within all seven districts region wer involved cross-sectional descriptive study. Data were collected 5 months from 26(th) November, 2010 25(th) April, 2011. We...
Sexual function is an important component of women's health that has not been traditionally emphasized during medical training, suggesting further education needed to provide comprehensive patient care. The purpose this study was describe and interest in female sexual among urogynecology providers.
Importance Comprehensive surgical training is an essential component of obstetrics and gynecology residency, yet subspecialty experience may be declining. Objective The objective this study was to describe trends in reported resident female pelvic medicine reconstructive surgery (FPMRS). Study Design This a retrospective analysis national case log reports from the Accreditation Council for Graduate Medical Education (ACGME) residents. Results From 2013 through 2019, ACGME collected data...
Background The Emerging Risk Factors Collaboration and JUPITER trial suggest elevated C-reactive protein (CRP) has an association with cardiovascular risk factors outcomes in primary prevention populations. Less is known about CRP elevation frequency subjects disease (CVD), particularly those well-controlled traditional lipids (LDL, HDL, triglycerides). Our study objective was to quantify prevalence of examine predictors a nationally representative secondary sample meeting NCEP lipid...
The formation of the furanyl aryl imine N-[4-(2-furanylmethyleneamino)benzylidene]furan-2-amine(1) was accomplished by condensation furfural with 1,4-benzenediamine.The structure dimine 1 confirmed X-ray crystallographic analysis and displayed expected, "zigzag" or trans conformation about bond.Quantum chemistry calculations were carried out to model electronic molecular corroborate experimental characterizations.2][3][4][5][6] Various heterocycles have been incorporated into conducting...