A5031270415- Lysosomal Storage Disorders Research
- Child Nutrition and Feeding Issues
- Glycogen Storage Diseases and Myoclonus
- Orthopedic Surgery and Rehabilitation
- Infant Nutrition and Health
- Sports injuries and prevention
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Foot and Ankle Surgery
- Pharmaceutical studies and practices
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Genomics, phytochemicals, and oxidative stress
- Healthcare Operations and Scheduling Optimization
- Advanced Fluorescence Microscopy Techniques
- Drug Transport and Resistance Mechanisms
- Family and Disability Support Research
- Carbohydrate Chemistry and Synthesis
- bioluminescence and chemiluminescence research
- Hospital Admissions and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Blood transfusion and management
- Effects and risks of endocrine disrupting chemicals
- Bacillus and Francisella bacterial research
Wagga Wagga Base Hospital
2022
Janssen (United States)
2015-2019
Prince of Wales Hospital
2018
Johnson & Johnson (United States)
2005-2015
Janssen (Belgium)
2011-2014
Sydney Hernia Specialists Clinic
2014
Intracisternal injection of cyclodextrin into cats with Niemann-Pick type C1 disease results in Purkinje cell survival and normal neurological function, suggesting its usefulness for treating the human disease.
Expanded options for treatments directed against pathogens that can be used bioterrorism are urgently needed. Treatment regimens such identified only by using data derived from in vitro and animal studies. It is crucial these studies reliably predict the efficacy of proposed humans. The objective this study was to identify a levofloxacin treatment regimen will serve as an effective therapy Bacillus anthracis infections postexposure prophylaxis. An hollow-fiber infection model replicates...
RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-; CAS Registry Number 194085-75-1) is a novel neuromodulator in clinical development for the treatment of epilepsy. To study disposition RWJ-333369, eight healthy male subjects received single oral dose 500 mg <sup>14</sup>C-RWJ-333369. Urine, feces, and plasma were collected analysis up to 1 week after dosing. Radioactivity was mainly excreted urine (93.8 ± 6.6%) much less feces (2.5 1.6%). extensively metabolized humans,...
To evaluate the effect of intra-articular tranexamic acid (TXA) on blood loss after total knee arthroplasty (TKA).Medical records 73 men and 93 women (mean age, 68 years) who underwent primary TKA for osteoarthritis received TXA 1500 mg (n=56) or 3000 not at all (n=54) were reviewed. Reduction in haemoglobin levels days 1 2 was measured, as rates venous thromboembolism (VTE) transfusion.Reduction day significantly greater controls (35 ± 11 g/dl) than group (29 9 g/dl, p=0.005) (23 10...
2-Hydroxypropyl-#x03B2;-cyclodextrin (HP-#x03B2;-CD), a widely used excipient for drug formulation, has emerged as an investigational new the treatment of Niemann-Pick type C1 (NPC1) disease, neurodegenerative cholesterol storage disorder. Development sensitive quantitative LC-MS/MS assay to monitor pharmacokinetics (PKs) HP-#x03B2;-CD required clinical trials been challenging owing dispersity HP-#x03B2;-CD. To support phase 1 trial ICV delivery in NPC1 patients, novel methods quantification...
The purpose of this study was to assess participation in sport and physical activity following open reduction internal fixation a Lisfranc injury cohort recreational athletes.This identified all adult patients aged 55 years or younger who presented with underwent (ORIF) using screw combined bridge plating technique. Sports assessed new sports-specific, patient-administered questionnaire. Clinical outcomes were the Foot Ankle Outcome Score (FAOS). Thirty-three qualified for (21 men/12 women)....
The pharmacokinetics, metabolism and excretion of monoethyl phthalate (MEP) diethyl (DEP) were compared after intravenous or oral administration [(14)C]MEP [(14)C]DEP in juvenile beagle dogs. Four male dogs treated with a single bolus dose either (164 μg/kg). absorption, metabolism, pharmacokinetics nearly identical. was rapidly completely metabolized to following administration. and[(14)C]DEP absorbed, the elimination half-life estimated be 1 hour. Approximately 90%-96% excreted urine 2%-3%...
Levofloxacin's metabolism, excretion, and in vitro plasma protein binding, together with its pharmacokinetics, were studied the Rhesus monkey support of an anthrax efficacy study this species. Three males three female monkeys dosed a single oral dose 14C-levofloxacin at 15 mg kg-1 (2 MBq kg-1). Following administration, blood samples collected up to 48 h post-dose, urine faeces quantitatively 168 post-dose. Blood, plasma, urine, analysed for total radioactivity. Metabolite profiling...
The in vivo metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (<i>S</i>)-], a novel neuromodulator, were investigated mice, rats, rabbits, dogs after oral administration <sup>14</sup>C-RWJ-333369. Plasma, urine, feces samples collected, assayed for radioactivity, profiled metabolites. In almost all species, the administered radioactive dose was predominantly excreted urine (>85%) with less than 10% feces. Excretion radioactivity rapid nearly...
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is an experimental therapy for Niemann-Pick disease type C (NPC) that reduced neuronal cholesterol and ganglioside storage, Purkinje cell death, increased lifespan in npc1-/- mice NPC1 cats. In this study, tissue distribution was investigated normal cats received a single 120-mg dose of [
Category: Trauma Introduction/Purpose: To assess participation in sport and physical activity following open reduction internal fixation of a Lisfranc injury cohort recreational athletes. Methods: Our study identified all adult patients aged 55 or less, who presented to our institution with underwent (ORIF) using screw combined bridge plating technique. Sports was assessed new sports-specific, patient-administered questionnaire. Clinical outcomes were the Foot Ankle Outcome Score (FAOS)....
Objective Optimal utilisation of theatre time increases efficiency and reduces the cost health care. The accuracy surgical estimation between different members team has not been well documented, may aid in more efficient available time. This study aims to identify cohort staff with greatest estimating orthopaedic Methods was conducted a prospective fashion using consecutive trauma elective operative lists over period 3 months. Prior each operating list, senior member anaesthetic, scrub/scout...
本来，包装用板紙抄紙は特にライナーと中芯では歩留り剤として硫酸バンドとロジンサイズを使う酸性システムとなっている。しかし現在，ライナーや中芯はロジンサイズからAKDまたはASAへと変わってきている。これはウェットエンドシステムを酸性から中性へ変更しなければならないことを意味している。この課題を解決するためには多くの問題に直面し，その解決方法を検討する必要がある。なぜ古紙原料板紙製造は世界的に酸性から中性へ変化しているのか？酸性から中性へシステムを移行するとき変更しなければならない必要な点は何か？古紙原料板紙製造において歩留り，中性サイズコントロールをどの様に実現するのか？中性板紙製造のポイントは再生古紙の中の炭酸カルシウムが増えると，古紙原料板紙システムが酸性から中性へと変化する傾向に選択の余地はない。もし酸性から中性へ抄紙マシンを変更すれば多くの利点があり製造コストの削減にもつながる。その上，ロジンの高い原料コストと予期しない供給サポート問題の点からも，酸性から中性への抄紙システム変更が求められる。2剤併用液体歩留プログラムは歩留り，濾水および強度特性のバランスを取りつつ，コス...