A5088534050- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Global Security and Public Health
- Poisoning and overdose treatments
- Epilepsy research and treatment
- Advanced Breast Cancer Therapies
- Anesthesia and Sedative Agents
- Disaster Response and Management
- Trace Elements in Health
- Species Distribution and Climate Change
- Lysosomal Storage Disorders Research
- BRCA gene mutations in cancer
- Antibiotics Pharmacokinetics and Efficacy
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Glycogen Storage Diseases and Myoclonus
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Vaccine Coverage and Hesitancy
- Metabolism and Genetic Disorders
- Menopause: Health Impacts and Treatments
- Electroconvulsive Therapy Studies
- Adenosine and Purinergic Signaling
- Analytical Methods in Pharmaceuticals
Edge Hill University
2025
Centers for Disease Control and Prevention
2017-2024
National Center for Emerging and Zoonotic Infectious Diseases
2020
Aidjan-Lagos Corridor Organization
2020
West African Health Organisation
2020
African Field Epidemiology Network
2020
Federal Ministry of Health
2017-2020
Nigeria Centre for Disease Control
2020
Ministry of Health
2020
Monterey Bay Aquarium Foundation
2020
Intracisternal injection of cyclodextrin into cats with Niemann-Pick type C1 disease results in Purkinje cell survival and normal neurological function, suggesting its usefulness for treating the human disease.
Estrogen modifies human emotion and cognition impacts symptoms of schizophrenia. We hypothesized that the variation in estrogen receptor alpha (ESR1) gene cortical ESR1 mRNA is associated with In a small case–control genetic association analysis postmortem brain tissue, genotype CC (rs2234693) haplotypes containing C allele single-nucleotide polymorphism (SNP) intron1 (PvuII) were more frequent African American schizophrenics (P = 0.01–0.001). follow-up family-based analysis, we found...
Abstract Preclinical studies have demonstrated synergy between PARP and PI3K/AKT pathway inhibitors in BRCA1 BRCA2 (BRCA1/2)–deficient BRCA1/2-proficient tumors. We conducted an investigator-initiated phase I trial utilizing a prospective intrapatient dose- escalation design to assess two schedules of capivasertib (AKT inhibitor) with olaparib (PARP 64 patients advanced solid Dose expansions enrolled germline BRCA1/2-mutant tumors, or BRCA1/2 wild-type cancers harboring somatic DNA damage...
Abstract Phenology—recurring seasonal events in an organism's life cycle—is largely driven by local climates <1 km 2 (microclimates), and changes phenology are frequently used to indicate a species’ or community response climate change. Phenological shifts can result trophic asynchrony, population declines of higher‐level consumers, reduction plant fitness. While timing phenological is often correlated with elevation, studies have shown that microclimates created areas heterogeneous...
Long-standing cultural, economic, and political relationships among Benin, Nigeria, Togo contribute to the complexity of their cross-border connectivity. The associated human movement increases risk international spread communicable disease. Benin ministries health Nigeria Centre for Disease Control, in collaboration with Abidjan Lagos Corridor Organization (a 5-country intergovernmental organization) US Centers Control Prevention, sought minimize outbreaks by defining implementing...
Recent multinational disease outbreaks demonstrate the risk of spreading globally before public health systems can respond to an event. To ensure global security, countries need robust multisectoral rapidly detect and domestic or imported communicable diseases. The US Centers for Disease Control Prevention International Border Team works with governments Nigeria, Togo, Benin, along Pro-Health Abidjan-Lagos Corridor Organization, build sustainable Health Regulations capacities at points entry...
Trade and business, need for health care, visits to family, refugee support, insecurity in the Democratic Republic of Congo (DRC) drive population movement patterns among Rwanda, Uganda, provinces eastern DRC that are experiencing an Ebola virus disease outbreak.
In Uganda, the borders are highly porous to animal movement, which may contribute zoonotic disease spread. We piloted an adaptation of existing human-focused toolkit collect data on movement patterns and interactions inform One Health programs. During January 2020, we conducted focus group discussions key informant interviews with participatory mapping 2 national-level stakeholders local-level abattoir representatives from Kampala. Zoonotic hotspots changed in 2020 compared reports...
Uganda's proximity to the tenth Ebola virus disease (EVD) outbreak in Democratic Republic of Congo (DRC) presents a high risk cross-border EVD transmission. Uganda conducted preparedness and risk-mapping activities strengthen capacity prevent importation spread from We adapted World Health Organization (WHO) Consolidated Preparedness Checklist assess 11 International Regulations domains at district level, health facilities, points entry; US Centers for Disease Control Prevention (CDC) Border...
Abstract Background: Preclinical synergy between PARP and PI3K pathway inhibition in BRCA m sporadic cancers provided rationale for this trial. Methods: Ola 300mg BID was combined with 2 schedules of AZD BID: 4 days on 3 off (4/7) 5 (2/7) using a novel intrapatient dose escalation design (Michalarea et al, AACR 2015). Cohort expansion pts gBRCA tumors relevant somatic mutations or BRCAness phenotype, assessed regimens: (1) + 400mg 4/7 (2) 640mg 2/7 AZD. Targeted next generation sequencing...
On August 1, 2018, the Democratic Republic of Congo (DRC) declared its 10th Ebola virus disease (Ebola) outbreak in an area with a high volume cross-border population movement to and from neighboring countries. The World Health Organization (WHO) designated Rwanda, South Sudan, Uganda as highest priority countries for preparedness because risk spread DRC (1). Countries might base their case definitions on global standards; however, historical context perceived often affect why modify adapt...
Abstract Complex human movement patterns driven by a range of economic, health, social, and environmental factors influence communicable disease spread. Further, cross-border impacts disparate public health systems neighboring countries, making an effective response to importation or exportation more challenging. Despite the array quantitative techniques social science approaches available analyze patterns, there continues be dearth methods within applied setting gather use information about...
2503 Background: ONX-0801 is a first-in-class alpha folate receptor (AFR) targeted thymidylate synthase inhibitor, engineered to differentially accumulate 6000-fold in AFR overexpressing cancer cells. Methods: A 3+3 dose escalation design was used and two IV schedules were explored. Schedule A, weekly dosing (QW) schedule B, once every 2 weeks (Q2W). cycle consisted of 4 treatment stopped after 6 cycles both schedules. An expansion cohort evaluate clinical activity patients with high grade...