A5084997308- Dementia and Cognitive Impairment Research
- Glioma Diagnosis and Treatment
- Neurobiology of Language and Bilingualism
- Vestibular and auditory disorders
- Brain Metastases and Treatment
- Alzheimer's disease research and treatments
- Neuroscience of respiration and sleep
- Language Development and Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Long-Term Effects of COVID-19
- Syntax, Semantics, Linguistic Variation
- Growth Hormone and Insulin-like Growth Factors
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Cognitive Functions and Memory
- Telemedicine and Telehealth Implementation
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Multiple Sclerosis Research Studies
- Cancer-related cognitive impairment studies
- Genetics and Neurodevelopmental Disorders
- Meningioma and schwannoma management
Massachusetts General Hospital
2016-2025
Harvard University
2013-2025
Boston University
2024
University of Basel
2022
Ragon Institute of MGH, MIT and Harvard
2022
University Hospital of Basel
2022
Athinoula A. Martinos Center for Biomedical Imaging
2022
Universidad Rey Juan Carlos
2022
Brigham and Women's Hospital
2022
Google (United States)
2021
Anatomical, physiological and functional neuroimaging studies suggest that the cerebellum participates in organization of higher order function, but there are very few descriptions clinically relevant cases address this possibility. We performed neurological examinations, bedside mental state tests, neuropsychological anatomical on 20 patients with diseases confined to cerebellum, evaluated nature severity changes function. Behavioural were prominent lesions involving posterior lobe vermis,...
Cerebellar cognitive affective syndrome (CCAS; Schmahmann's syndrome) is characterized by deficits in executive function, linguistic processing, spatial cognition, and affect regulation. Diagnosis currently relies on detailed neuropsychological testing. The aim of this study was to develop an office or bedside screen help identify CCAS cerebellar patients. Secondary objectives were evaluate whether available brief tests mental function detect impairment patients, performance different...
Cerebellar lesions can cause motor deficits and/or the cerebellar cognitive affective syndrome (CCAS; Schmahmann's syndrome). We used voxel-based lesion-symptom mapping to test hypothesis that results from anterior lobe damage whereas in posterolateral cerebellum produce CCAS. Eighteen patients with isolated stroke (13 males, 5 females; 20–66 years old) were evaluated using measures of ataxia and neurocognitive ability. Patients showed a wide range performance, normal severely impaired;...
Hypopituitarism in women is characterized by profound androgen deficiency due to a loss of adrenal and/or ovarian function. The effects testosterone replacement this population have not been reported.The objective the study was determine whether physiologic improves bone density, body composition, neurobehavioral function with severe secondary hypopituitarism.This 12-month randomized, placebo-controlled study.The conducted at general clinical research center.Fifty-one reproductive age...
With the recent publication of new criteria for diagnosis preclinical Alzheimer's disease (AD), there is a need neuropsychological tools that take premorbid functioning into account in order to detect subtle cognitive decline. Using demographic adjustments one method increasing sensitivity commonly used measures. We sought provide useful online z-score calculator yields estimates percentile ranges and adjusts individual performance based on sex, age and/or education each tests National...
BACKGROUND In this prospective study, the authors evaluated potential treatment toxicity and progression‐free survival in patients with low‐grade glioma who received proton radiation therapy. METHODS Twenty World Health Organization grade 2 were eligible for therapy enrolled a prospective, single‐arm trial of The at dose 54 Gy (relative biological effectiveness) 30 fractions. Comprehensive baseline regular post‐treatment evaluations neurocognitive function, neuroendocrine quality life (QOL)...
GH replacement of adults with acquired deficiency (GHD) results in body composition changes including increases lean mass and bone mineral density. However, the effects long-term therapy on cognitive function are largely unknown, there conflicting data regarding quality life. We performed a randomized, double-blind, placebo-controlled study GHD measured cognition sense well-being using standardized psychometric tests before after therapy. Forty men (median age 51 yr, range 24–64 yr) history...
In Brief BACKGROUND: The etiology of postoperative cognitive decline (POCD) remains to be determined. Anesthetic isoflurane, but not desflurane, may induce neurotoxicity. However, the functional consequences these effects have been assessed. We therefore performed a pilot study determine isoflurane and desflurane on function in humans. METHODS: subjects included patients who had lower extremity or abdominal surgery under spinal anesthesia alone (S, n = 15), plus (SD, (SI, 15) by...
Determination of biomarker and neuropathogenesis postoperative cognitive change (POCC) or dysfunction.POCC is one the most common complications in elderly patients. Whether preoperative cerebrospinal fluid (CSF) β-amyloid protein (Aβ) to tau ratio, an Alzheimer disease biomarker, a for risk POCC remains unknown. We therefore set out assess association between CSF Aβ42 Aβ40 ratio POCC.Patients who had total hip/knee replacement were enrolled. The was obtained during administration spinal...
Abstract Objective To evaluate alterations in apparent axon diameter and density obtained by high‐gradient diffusion MRI the corpus callosum of MS patients relationship these advanced metrics to neurologic disability cognitive impairment MS. Methods Thirty people with (23 relapsing‐remitting [RRMS], 7 progressive [PMS]) 23 healthy controls were scanned on a human 3‐tesla (3T) scanner equipped 300 mT/m maximum gradient strength using comprehensive multishell protocol. Data fitted...
The implementation of the Montreal Protocol, Clean Air Act, and Pollution Prevention Act 1990 has resulted in increased awareness organic solvent use chemical processing. advances made search to find
Objective Obesity has been associated with cognitive decline in longitudinal studies of older individuals. We hypothesized that the sequelae obesity may be detectable reproductive years. In addition, we explored hypothesis these associations mediated by hormonal milieu. Design and Methods Of 49 young healthy lean overweight women aged 20‐45, investigated association between performance on a battery tests, body composition parameters [body mass index, total fat, abdominal (visceral,...
This article concerns how the orientations of objects are represented in human brain. We propose a coordinate-system hypothesis orientation representation (COR) and show that provides an explicit basis for interpreting errors. Next, we report results from three studies individuals with developmental deficits processing information, demonstrating COR can interpret error patterns each study. conclude by discussing several issues concerning interpretation our results, hypothesis, use as...
Joubert syndrome (JS) is a rare, autosomal recessively inherited genetic disorder characterized morphologically by unique developmental malformations of the cerebellum and brainstem (the molar tooth sign), clinically impaired motor functions intellectual disability. Patients with JS often face multiple cognitive challenges, but neuropsychological profile this condition has not been well characterized. We performed comprehensive neurological evaluations in three adult brothers JS, ages 32,...