A5100435038- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Herbal Medicine Research Studies
- Neuroscience of respiration and sleep
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Barrier Structure and Function Studies
- Medicinal Plants and Bioactive Compounds
- Organic Chemistry Cycloaddition Reactions
- Ion channel regulation and function
- Advanced Neuroimaging Techniques and Applications
- Cardiac and Coronary Surgery Techniques
- Neuropeptides and Animal Physiology
Ruijin Hospital
2013-2023
Shanghai Jiao Tong University
2011-2022
Massachusetts General Hospital
2017
Harvard University
2017
Zero to Three
2014
Shanghai Institute of Hematology
2008
Marymount University
2008
Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of current study was to compare xenon, argon, and helium a neonatal asphyxia model rats.Randomized controlled trial.Laboratory.Seven-day-old postnatal Sprague-Dawley rats.Seventy percent helium, or nitrogen balanced with oxygen after hypoxic-ischemic brain injury.Control animals undergoing moderate hypoxic-ischemia endured reduced neuronal survival at 7 days impaired...
Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane is a commonly used anesthetic in children. Tau phosphorylation contributes dysfunction. The authors therefore assessed the effects sevoflurane on underlying mechanisms young mice.
Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity mortality. The current treatment for SAE mainly symptomatic; the lack of specific options a poor understanding underlying mechanism disease are responsible patient outcomes. Fgr member Src family tyrosine kinases involved in innate immune response, hematologic cancer, diet-induced obesity, hemorrhage-induced thalamic pain. This study investigated...
Perinatal hypoxia-ischemia causes significant morbidity and mortality. Xenon sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated potential application of these agents independently in combination to attenuate perinatal injury.Oxygen-glucose deprivation injury was induced pure neuronal or neuronal-glial cocultures 24 h after preconditioning with xenon and/or sevoflurane. Cell death assessed by lactate dehydrogenase release staining annexin...
Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane, a commonly used anesthetic in children, has been reported decrease levels postsynaptic density 95 protein. However, the upstream mechanisms downstream consequences sevoflurane-induced reduction protein remains largely unknown. We therefore set out assess whether sevoflurane acts on ubiquitination-proteasome pathway facilitate degradation.Six-day-old wild-type...
There is a need to seek new treatment(s) for Alzheimer's disease (AD). A recent study showed that AD patients may have decreased levels of functional GABA receptors. Propofol, commonly used anesthetic, receptor agonist. We therefore set out perform proof concept determine whether chronic treatment with propofol (50 mg/kg/week) can improve cognitive function in both aged wild-type (WT) and transgenic (Tg) mice. Propofol was administrated the WT Tg mice once week 8 or 12 weeks, respectively....
Demand is increasing for safer inhalational anesthetics use in pediatric anesthesia. In this regard, researchers have debated whether isoflurane more toxic to the developing brain than desflurane. present study, we compared effects of postnatal exposure with those desflurane on long-term cognitive performance and investigated role Akt/GSK3 β signaling pathway. Postnatal day 6 (P6) mice were exposed either or desflurane, after which phosphorylation levels learning memory assessed at P8 P31....
Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on developing brain. Clinical interventions and treatments for these are limited. Tanshinone IIA (Tan IIA), extracted from Salvia miltiorrhiza (Danshen), documented alleviate cognitive decline traditional applications. Therefore, we hypothesized that preadministration of Tan may attenuate sevoflurane-induced neurotoxicity,...
Background It has been reported that bilateral lesions of the basolateral amygdala complex (BLA) blocked propofol-induced amnesia inhibitory avoidance (IA) training. Based on these results, authors hypothesized effect propofol was partly due to its impairment memory formation in hippocampus through activating BLA gamma-aminobutyric acid type A receptor function. The determined changes activity-regulated cytoskeleton-associated protein (Arc) expression be an indicator IA formation. Methods...
Resting-state functional magnetic resonance imaging (fMRI) has been used to detect the alterations of spontaneous neuronal activity in various neurological and neuropsychiatric diseases, but rarely hemifacial spasm (HFS), a nervous system disorder. We resting-state fMRI with regional homogeneity (ReHo) analysis investigate changes brain patients HFS determine relationship these clinical features. Thirty 33 age-, sex-, education-matched healthy controls were included this study. Compared...
A novel stomach-derived peptide, ghrelin, is down-regulated in sepsis and its IV administration decreases proinflammatory cytokines mitigates organ injury. In this study, we wanted to investigate the effects of ghrelin on responses cognitive impairment septic rats.Prospective, randomized, controlled experiment.Animal basic science laboratory.Sprague-Dawley rats, weighing 250-300 g.Sepsis was induced by cecal ligation puncture. Animals were randomly divided into four groups: sham, sham +...
Sevoflurane exposures were demonstrated to induce neurotoxicity in the developing brain both human and animal studies. However, there is no effective approach reverse it. The present study aimed evaluate feasibility of utilizing docosahexaenoic acid (DHA) prevent sevoflurane-induced neurotoxicity. P6 (postnatal 6 days) mice administrated DHA after exposure 3% sevoflurane for two hours daily three consecutive days. Molecular expressions synaptic makers (PSD95, synaptophysin) morphological...
Abstract Sevoflurane, a commonly used anesthetic, may cause agitation in patients. However, the mechanism underlying this clinical observation remains largely unknown. We thus assessed effects of sevoflurane on neuronal activation and behaviors mice. Ten-day-old mice received 2% sevoflurane, 1% isoflurane, or 6% desflurane for 10 minutes. The behavioral activities were recorded evaluated at one minute after loss righting reflex mice, which was about two minutes anesthetic administration. by...
Isoflurane exposure adversely influences subsequent fear memory formation in mice. Calcineurin (CaN), a phosphatase, prevents the establishment of emotional by dephosphorylating substrates and inhibiting expression learning related genes. We investigated whether isoflurane impairment was associated with altered CaN activity downstream phosphorylated-extracellular signal-regulated kinases (p-ERK) early growth response gene-1 (Egr-1) hippocampus amygdala. also tested performance can be rescued...
This study aimed to investigate whether the regulation of 5-hydroxytryptamine-7 (5-HT7) receptors in bilateral basolateral amygdala (BLA) could alter amnesic effects sevoflurane and change hippocampal expression Arc neural apoptosis. Male Sprague-Dawley rats were randomized into ten groups. First, animals received injection SB269970 (20, 50, or 100 pmol/0.2 μl) saline (0.2 AS-19 (2, 10, 50 μl), followed by inhalation 2% air for 2 h. Then, fear conditioning training was carried out,...