A5029304304- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Neuroscience of respiration and sleep
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Asthma and respiratory diseases
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Intracerebral and Subarachnoid Hemorrhage Research
- Respiratory and Cough-Related Research
- Neuroendocrine regulation and behavior
- PI3K/AKT/mTOR signaling in cancer
- vaccines and immunoinformatics approaches
- Extracellular vesicles in disease
- Parathyroid Disorders and Treatments
Guizhou Provincial People's Hospital
2017-2025
Hangzhou First People's Hospital
2018-2025
Zhejiang Chinese Medical University
2024-2025
Ruijin Hospital
2010-2024
Westlake University
2024
Zhejiang University
2013-2024
Southeast University
2007-2024
Shanghai Jiao Tong University
2014-2024
Guangzhou Medical University
2024
Guizhou University
2018-2023
COVID-19 has recently become the most serious threat to public health, and its prevalence been increasing at an alarming rate. The incubation period for virus is approximately 1–14 days all age groups may be susceptible a fatality rate of about 5.9%. caused by novel single-stranded, positive (+) sense RNA beta coronavirus. development vaccine SARS-CoV-2 urgent need worldwide. Immunoinformatics approaches are both cost-effective convenient, as in silico predictions can reduce number...
Abstract M2 polarization of macrophages is essential for their function in immunologic tolerance, which might promote tumorigenesis. However, the molecular mechanism behind process not fully understood. Given that several lines evidence have suggested long noncoding RNAs (lncRNAs) could be involved regulating immune cell differentiation and function, current study aimed to identify lncRNAs specifically modulate macrophage polarization. By utilizing a series cell-based models, total 25 with...
// Jun Zhang 1,* , Ji Cao Shenglin Ma 2,3 Rong Dong 1 Wen Meng 2 Meidan Ying Qinjie Weng Zibo Chen 5 Jian Qingxia Fang 4 Qiaojun He and Bo Yang Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute Pharmacology Toxicology, College Pharmaceutical Sciences, University, Hangzhou, China Hangzhou First People’s Hospital, Huansha Road, 3 The second Clinical Medical College, Chinese Provincial hospital, Shangtang Materials Science Engineering, Central South University...
Aim: Chemotherapy-induced reactive oxygen species (ROS) not only contribute to apoptosis, but also trigger autophagy. Since autophagy is reported protect cancer cells from this weakens the therapeutic effect of chemotherapy. This study aimed at identifying key molecules that determine cellular response ROS and, therefore, provide better strategies increase chemotherapeutic efficiency. Results: Increasing concentrations N-(4-hydroxyphenyl) retinamide (4-HPR)-treatment pushed down apoptosis in...
Abstract Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of metastatic character. However, connections between these phenomena are not fully understood. In this study, we define an integrative role for E3 ubiquitin ligase subunit WSB1. primary osteosarcomas, increased levels WSB1 correlated pulmonary potential. RNAi-mediated attenuation or disruption its activity potently suppressed tumor metastasis. Quantitative proteomic and functional analyses...
Long noncoding RNAs (lncRNAs) have been reported to play an important role in diabetic nephropathy (DN). However, the molecular mechanism involved this process remains poorly understood. Thus, present study aimed explore function and of dysregulated lncRNA X-inactive specific transcript (XIST) DN. DN mouse models were established by streptozotocin treatment, human renal tubular epithelial HK-2 cells exposed high glucose produce vitro model. XIST was highly expressed tissues patients with DN,...
Importance Older patients may benefit from the hemodynamic stability of etomidate for general anesthesia. However, it remains uncertain whether potential adrenocortical suppression with increase morbidity. Objective To test primary hypothesis that vs propofol anesthesia does not in-hospital morbidity after abdominal surgery in older patients. Design, Setting, and Participants This multicenter, parallel-group, noninferiority randomized clinical trial (Etomidate Propofol In-hospital...
The complex relationship between Th1 and Th17 cells is incompletely understood. transcription factor T-bet best known as the master regulator of lineage commitment. However, attention now focused on repression alternate T cell subsets mediated by T-bet, particularly lineage. It has recently been suggested that pathogenic express are dependent IL-23. previously shown to be a negative cells. We have taken an unbiased approach determine functional impact Genome-wide analysis binding sites...
Nirmatrelvir/ritonavir is licensed for the treatment of mild-to-moderate coronavirus disease (COVID-19) in patients at an increased risk progression to severe disease. However, data on real-world plasma exposure nirmatrelvir/ritonavir remain limited, particularly Chinese patients. This study aimed assess trough concentration (Ctrough) and identify its critical factors hospitalized treated with 300 mg/100 mg twice daily over a 5-day course. A high-performance liquid chromatography-tandem mass...
Objective: To investigate the correlation of lipid profile and serum osmolality (OsP) with kidney progression in patients type 2 diabetes mellitus (T2DM). Methods: A nested case-control study was conducted. Inpatients T2DM who visited Guizhou Provincial People's Hospital 2019 were included. Demographic characteristics, laboratory indices, events collected. The OsP analyzed using multivariable Cox proportional hazards regression models causal mediation analysis. Results: total 1 219 (714...