A5041597242- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Advanced Nanomaterials in Catalysis
- Sleep and Wakefulness Research
- Infectious Encephalopathies and Encephalitis
- Muscle and Compartmental Disorders
Zhejiang Chinese Medical University
2019-2025
Nirmatrelvir/ritonavir is licensed for the treatment of mild-to-moderate coronavirus disease (COVID-19) in patients at an increased risk progression to severe disease. However, data on real-world plasma exposure nirmatrelvir/ritonavir remain limited, particularly Chinese patients. This study aimed assess trough concentration (Ctrough) and identify its critical factors hospitalized treated with 300 mg/100 mg twice daily over a 5-day course. A high-performance liquid chromatography-tandem mass...
In recent years, the frequency of strokes has been on rise year by and become second leading cause death around world, which is characterized a high mortality rate, recurrence disability rate. Ischemic account for large percentage strokes. A reperfusion injury in ischemic complex cascade oxidative stress, neuroinflammation, immune infiltration, mitochondrial damage. Conventional treatments are ineffective, presence blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so...
Spinosin, a major component of Samen Ziziphi spinosae, has been shown to modulate sedation and hypnosis; however, the underlying neuronal mechanisms its stimulatory effects remain unclear.In present study, we injected spinosin (15 mg/kg) or saline into mice, which were killed after 90 min. We isolated brains, immunohistochemically stained for c-Fos as biomarker activation assessed expression profile in various sleep-arousal brain areas.Our findings revealed that there no statistically...