A5082453886- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Intensive Care Unit Cognitive Disorders
- Cerebrospinal fluid and hydrocephalus
- Sarcoma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Spinal Dysraphism and Malformations
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac tumors and thrombi
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Atomic and Subatomic Physics Research
- Musculoskeletal pain and rehabilitation
- Meningioma and schwannoma management
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Complement system in diseases
- Anesthesia and Sedative Agents
- Bone Tumor Diagnosis and Treatments
- Family and Patient Care in Intensive Care Units
- Facial Nerve Paralysis Treatment and Research
- Dental Anxiety and Anesthesia Techniques
- Neuroscience of respiration and sleep
Tongji Hospital
2017-2025
Huazhong University of Science and Technology
2017-2025
Shanghai East Hospital
2024
Creative Commons
2017
Zunyi Medical University
2011-2015
Ruijin Hospital
2015
Shanghai Jiao Tong University
2015
Central Taiwan University of Science and Technology
2011
National Defense Medical Center
1981-1993
Tri-Service General Hospital
1981-1988
Abstract Background and Hypothesis Despite the well-documented structural functional brain changes in schizophrenia, potential role of glymphatic dysfunction remains largely unexplored. This study investigates system’s function utilizing diffusion tensor imaging (DTI) to analyze water along perivascular space (ALPS), examines its correlation with clinical symptoms. Study Design A cohort consisting 43 people schizophrenia 108 healthy controls was examined. We quantified metrics x-, y-, z-axis...
Objectives. There is a known association of imbalanced peripheral tolerance and autoimmune diseases. The binding programmed cell death 1 (PD-1) with its ligands 2 (PD-L1 PD-L2) inhibits T-cell proliferation through negative signal via recruitment src homology 2-domain-containing tyrosine phosphatase 2. Therefore we evaluated the effect PD-1, PD-L1 PD-L2 genotypes on occurrence AS in population Taiwanese patients. Methods. Genetic polymorphisms PD-1 G-536A, A8923C C47103T were identified by...
Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role the pathogenesis of Alzheimer's disease, diabetes, atherosclerosis, cancer, etc. In this study, we provide first direct evidence that ER may be significant driver morphine tolerance. Binding immunoglobulin protein (BiP), marker, was significantly upregulated neurons spinal dorsal horn rats being treated with for...
Abstract Hyperglycemia commonly occurs in severe cases with COVID‐19. In this study, we explored the associations between admission fasting plasma glucose (FPG) and 28‐day mortality COVID‐19 patients. single centre retrospective 263 adult patients were included. Demographic clinical information collected compared without diabetes. Cox regression analyses used to investigate risk factors of hospitals. Of patients, 161 (61.2%) male, 62 (25.6%) had a known history diabetes, 135 (51.3%)...
Resting-state functional magnetic resonance imaging (fMRI) has been used to detect the alterations of spontaneous neuronal activity in various neurological and neuropsychiatric diseases, but rarely hemifacial spasm (HFS), a nervous system disorder. We resting-state fMRI with regional homogeneity (ReHo) analysis investigate changes brain patients HFS determine relationship these clinical features. Thirty 33 age-, sex-, education-matched healthy controls were included this study. Compared...
Rationale: Early invasive ventilation may improve outcomes for critically ill patients with COVID-19. The objective of this study is to explore risk factors 28-day mortality COVID-19 receiving ventilation. Methods: 74 consecutive adult invasively ventilated were included in retrospective study. demographic and clinical data compared between survivors non-survivors, Cox regression analysis was used mortality. primary outcome after initiation Secondary the time from admission intubation....
Eculizumab, a recombined humanized monoclonal antibody which possesses high affinity for the complement protein C5, is therapeutic agent utilized in treatment of atypical hemolytic uremic syndrome (aHUS) by inhibiting terminal complex C5b-9. In pediatric patient with aHUS 14 months, administration eculizumab therapy was accompanied inclusion meningococcal vaccine as part national immunization program. Notably, no other antibiotics were administered prior to or during course treatment....
Anesthesia, a state of profound central nervous system suppression, involves sequence events that is still not well understood. In the present study, we examined action propofol (a sedative-hypnotic drug commonly used as anesthetic) on thalamocortical functional connectivity in rats by using magnetic resonance imaging (fcMRI) with 3.0-tesla MR scanner. Intraperitoneal injections (80 or 160 mg/kg) were administered to Sprague-Dawley rats. Synchronized low-frequency fluctuations (LFF) blood...
Background Postoperative cognitive impairment is a common complication after cardiac and major non-cardiac surgery in the elderly, but its causes mechanisms remain unclear. The purpose of current study was to use resting-state functional magnetic resonance imaging (fMRI) explore changes connectivity, i.e. synchronization low frequency fluctuation (LFF), an animal model aged rats. Methods Aged (22 months) rats were anaesthetized with 40 µg/kg fentanyl 500 droperidol (intraperitoneal) for...
A 7-year-old, female, domestic medium-haired cat had a recurrent deep dermal mass in the interscapular region after initial surgical removal 3 months earlier. The received killed rabies vaccine and five-in-one same area about 2 prior to first surgery. relapsed was diagnosed as vaccine-associated sarcoma. euthanized later because of hind limb paralysis. At necropsy, multiple, poorly demarcated, nodular masses were seen muscles around shoulders, neck, thoracic vertebrae. Pulmonary metastasis...
The development of antinociceptive morphine tolerance is a clinically intractable problem. Earlier work has demonstrated the pivotal roles PDGF and its receptor PDGFRβ in tolerance. Here, we have investigated role spinal heat shock protein 27 (HSP27) relationship with activation.
Dexmedetomidine combined with opioids has been extensively used to blunt cardiovascular responses endotracheal intubation. To determine their interaction, we aimed develop a response surface model between dexmedetomidine and sufentanil.One hundred twenty patients undergoing scheduled gynaecological surgery were recruited. According simulation of slice design, received different dose pairs (0 1.1 μg/kg) sufentanil (.1 .5 μg/kg). The mean arterial blood pressure heart rate recorded just before...
A young man suffered from a tumor mass in the skull, which proved to be rare case of primary osteogenic sarcoma. The histological findings obtained at autopsy showed metastatic lesions lungs, left diaphragm, and other areas. diagnosis, treatment, this are presented. (Neurosurgery 9:307-310, 1981)
Abstract A young man suffered from a tumor mass in the skull, which proved to be rare case of primary osteogenic sarcoma. The histological findings obtained at autopsy showed metastatic lesions lungs, left diaphragm, and other areas. diagnosis, treatment, this are presented.
Abstract Background Although neuroanatomical studies correlated to fibromyalgia (FM) are gaining increasing interest, the cortical morphology of patients largely unknown, and data on gyrification scarce. The objective present study is assess in female with FM compared healthy controls (HC) using surface-based morphometry (SBM) analysis magnetic resonance imaging (MRI). Methods T1-MRIs clinical 20 HC subjects were obtained from a public set via OpenNeuro. For each subject, surface parameters...