A5103644420- Congenital heart defects research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Laser Applications in Dentistry and Medicine
- RNA modifications and cancer
- Nanocomposite Films for Food Packaging
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- biodegradable polymer synthesis and properties
- Hydrogen's biological and therapeutic effects
- Pluripotent Stem Cells Research
- Cancer-related gene regulation
- Biochemical effects in animals
- Postharvest Quality and Shelf Life Management
- Renal and related cancers
- Cardiac Structural Anomalies and Repair
- HVDC Systems and Fault Protection
- Proteins in Food Systems
- Cardiac Valve Diseases and Treatments
- Heat shock proteins research
- Photoreceptor and optogenetics research
- Mesenchymal stem cell research
Second Affiliated Hospital of Harbin Medical University
2017-2025
Harbin Medical University
2016-2025
Shanghai Ocean University
2023-2025
Binzhou Medical University
2024
Binzhou University
2024
University of Glasgow
2022
Henan Agricultural University
2022
Chongqing Normal University
2016
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development pathogenesis. However, the potential involvement of m6A in regulation cardiomyocyte (CM) proliferation cardiac regeneration remains unclear. In this study, we aimed to investigate role modification heart during postnatal adult injury. Methods results: identified downregulation demethylase ALKBH5, an "eraser" that responsible increased methylation, after birth. Notably, ALKBH5...
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity differentiate into different cell lineages. Maintaining a balanced differentiation program is crucial bone microenvironment and development. MicroRNAs (miRNAs) played critical role in regulating of BMSCs particular lineage. However, miR-149-3p adipogenic osteogenic has not extensively discovered. In this study, we aimed detect expression levels during investigate whether participated lineage choice...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and shift between osteogenic adipogenic differentiation determines bone mass. The aim of this study was identify whether lncRNAs are involved in commitment BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels BMSCs, tissue, serum OVX-induced osteoporotic mice than...
Melatonin, a hormone secreted by the pineal gland, possesses multiple biological activities such as antitumor, antioxidant, and anti-ischemia. C-kit(+) cardiac progenitor cells (CPCs) have emerged promising tool for treatment of heart diseases. However, senescence CPCs due to pathological stimuli leads decline CPCs' functions regenerative potential. This study was conducted demonstrate whether melatonin antagonizes in response oxidative stress. Here, we found that markedly inhibited...
Abstract Translational control is crucial for protein production in various biological contexts. Here, we use Ribo-seq and RNA-seq to show that genes related oxidative phosphorylation are translationally downregulated during heart regeneration. We find Nat10 regulates the expression of Uqcr11 Uqcrb mRNAs mouse human cardiomyocytes. In mice, overexpression cardiomyocytes promotes cardiac regeneration improves function after injury. Conversely, treating neonatal mice with Remodelin—a...
Osteoporosis is closely associated with the dysfunction of bone metabolism, which caused by imbalance between new formation and resorption. Osteogenic differentiation plays a vital role in maintaining balance microenvironment. The present study investigated whether melatonin participated osteogenic commitment marrow mesenchymal stem cells (BMSCs) further explored its underlying mechanisms. Our data showed that exhibited capacity regulating BMSCs, was blocked membrane receptor inhibitor...
Background/Aims: Blue light emitting diodes (LEDs) have been proven to affect the growth of several types cells. The effects blue LEDs not tested on bone marrow-derived mesenchymal stem cells (BMSCs), which are important for cell-based therapy in various medical fields. Therefore, aim this study was determine LED proliferation, apoptosis and osteogenic differentiation BMSCs. Methods: BMSCs were irradiated with a at 470 nm 1 min, 5 10 30 min 60 or irradiated. Cell proliferation measured by...
In this study, chitosan (CS) was grafted onto the surface of polylactic acid (PLA) film by covalent immobilization to prepare four kinds CS-grafted PLA (CS-g-PLA) films with different molecular weights. The properties were characterized, and their antibacterial effect mechanism action against Staphylococcus aureus (S. aureus) explored. After being treated CS-g-PLA films, cell morphology destroyed, permeability membrane changed, malate dehydrogenase (MDH) activity decreased. Furthermore,...
To address unpredictable flavor changes in postharvest peaches during storage, this study investigated the use of bioactive packaging with melatonin-infused P34HB films. Films melatonin concentrations 0%, 1%, 3%, and 5% were prepared using extrusion casting method applied to peach storage at room temperature. Comprehensive film properties characterized, showing that minimally impacted films' mechanical properties, including gas water vapor permeability, but significantly increased haze....