A5100630482- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- Air Quality and Health Impacts
- Autophagy in Disease and Therapy
- Reproductive Physiology in Livestock
- Vehicle emissions and performance
- Energy and Environment Impacts
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Sperm and Testicular Function
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Occupational and environmental lung diseases
- Climate Change and Health Impacts
- Biopolymer Synthesis and Applications
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- NF-κB Signaling Pathways
- Pregnancy-related medical research
South China Normal University
2022-2025
Shuguang Hospital
2015-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
Qingdao University
2019-2024
Hebei General Hospital
2023
North China University of Science and Technology
2023
Fuzhou University
2023
Tianjin Hospital
2023
Tianjin Medical University General Hospital
2023
Northwest A&F University
2017-2022
Identification of aberrant microRNA (miRNA) expression during chemical carcinogen–induced cell transformation will lead to a better understanding the substantial role miRNAs in cancer development. To explore whether can be used as biomarkers exposure risk assessment carcinogenesis, we analyzed miRNA profiles human bronchial epithelial cells expressing an oncogenic allele H-Ras (HBER) at different stages induced by benzo(a)pyrene (BaP) array. It revealed 12 differentially expressed HBER both...
Follicular atresia is closely related to both apoptosis and autophagy of granulosa cells (GCs) in ovarian follicles. In the present study, GCs were isolated from pig ovaries small, medium large antral follicles, current results showed that proliferation was higher lower follicles compared small The Bax Caspase 3 mRNA levels significantly higher, but ratio Bcl-2/Bax marker genes autophagy, Atg3, Atg7 LC3 Apoptosis- autophagy-related proteins had a similar expression pattern level. Our...
It is well documented that granulosa cell apoptosis the main reason for follicular atresia and death; however, increasing evidence suggests autophagy plays an important role in fate of cells. miR-21-3p regulates many fundamental biological processes pivotal tumor cells; nevertheless, cattle ovary how cells unknown. In this study, we aimed to elucidate using bovine primary ovarian (BGCs). The results showed first time BGCs large follicle according autophagic gene transcript LC3, BECN-1, ATG3,...
Sepsis-induced lung injury is an acute hypoxic respiratory insufficiency caused by systemic infectious factors that results in alveolar epithelial cell and capillary endothelial injury, diffuse pulmonary interstitial edema, edema. Heme oxygenase (HO)-1 usually associated with inflammation has anti-inflammatory effects. Autophagy a degradation pathway eliminates cellular metabolic waste plays important protective role during stress. The phosphatidylinositol 3-kinase/ protein kinase B...
In the present study, AA was used to challenge bovine ovarian granulosa cells in vitro and related parameters of cellular molecular biology were measured. The results indicated that lower doses increased survival whereas higher suppressed survival. While induced accumulation lipid droplet cells, dose inhibited accumulation, abundance FABP3, CD36 SLC27A1 mRNA. Higher decreased secretion E2 P4 accompanied by down-regulation mRNA CYP19A1, FSHR, HSD3B1 STAR cells. signaling pathways employed...
Background/Aims: Bone marrow-derived mesenchymal stem cells (MSCs) are responsible for new bone formation during adulthood. Accumulating evidences showed that Osthole promotes the osteogenic differentiation in primary osteoblasts. The aim of this study was to investigate whether exhibits a potential stimulate MSCs and underlying mechanism. Methods: were treated with gradient concentration (6.25 µM, 12.5 25 µM). Cell proliferation assessed by western blotting proliferating cell nuclear...
This study aims to evaluate the mediation effect of dyslipidemia induced inflammation on causal associations between obesity and Osteoarthritis (OA). cross-sectional used data from National Health Nutrition Examination Survey (1999–2010). The association general abdominal (exposure), OA (outcome) mediators (total cholesterol, high-density lipoprotein, C-reactive protein) was assessed using multivariate linear logistic regression models analysis. A total 23,308 participants were enrolled in...
Abstract Obesity, a significant global health issue, heightens the risk of non-alcoholic fatty liver disease (NAFLD). Its interaction with environmental pollutants might exacerbate NAFLD's severity. Haloacetamides (HAcAms), group emerging nitrogenous disinfection by-products (DBPs) and potent oxidative stressors, are found in chlorinated drinking water. Since stress is associated HAcAms-DBPs cytotoxicity key factor NAFLD pathogenesis, we hypothesize that could injury NAFLD, particularly...
The aim of our study was to determine whether silencing or overexpression estrogen receptor β (ERβ) regulates cell proliferation, steroidogenesis, autophagy and signalling pathways in bovine ovarian granulosa cells vitro. In this study, (BGCs) were cultured transfected with ERβ siRNA (si-ERβ) a plasmid overexpressing (oe-ERβ), CCK-8 kit used assess proliferation. Real-time PCR measure gene transcription. Western blotting protein expression, specific the production steroid hormones. results...
Diesel exhaust is an established human carcinogen, however the mechanisms by which it leads to cancer development are not fully understood. Mitochondrial dysfunction contributor carcinogenesis. Recent studies have improved our understanding of role played epigenetic modifications in mitochondrial genome on tumorigenesis. In this study, we aim evaluate association between diesel engine (DEE) exposure with DNA (mtDNA) methylation levels workers exposed DEE.The study population consisted 53...
Abstract Falls in late postmenopausal women with osteopenia usually cause fractures severe consequences. This 36-month randomized, double-blind and placebo-controlled trial a 10-year observational follow-up study aimed to investigate the long-term effect of herbal formula Bushen Yijing Fang (BSYJF) on fall risk osteopenia. 140 (Femoral neck T-score, −2.5~−2 SD) were recruited randomized orally receive calcium carbonate 300 mg daily either BSYJF or placebo for 36 months. The was further...
Previous studies have shown an etiologic link between exposure to PAHs and lung cancer development.
Female animals living in the Qinghai-Tibet Plateau have lower ovulation rates because of hypoxic environment, however, mechanism hypoxia on animal follicles is unclear. In this study, effects bovine were investigated using an vitro follicular culture system. The results show that there was a significant decrease diameter from day 3 to 6 both and with estrogen (E2) fulvestrant (ICI 182780) (hypoxia + E2 ICI) groups, when compared normoxia group (p < 0.05). We also observed downregulation...