A5102025336- Public Policy and Administration Research
- Muscle Physiology and Disorders
- Mental Health and Patient Involvement
- Community Health and Development
- Social Capital and Networks
- Myasthenia Gravis and Thymoma
- Nonprofit Sector and Volunteering
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Genetic Neurodegenerative Diseases
- interferon and immune responses
- MicroRNA in disease regulation
- Amyotrophic Lateral Sclerosis Research
- Inflammasome and immune disorders
- Telomeres, Telomerase, and Senescence
- Policy Transfer and Learning
- Autoimmune Neurological Disorders and Treatments
- Statistical Methods and Inference
- Cancer-related molecular mechanisms research
- Political Influence and Corporate Strategies
- Management and Organizational Studies
- Electoral Systems and Political Participation
- Nuclear Structure and Function
- Knowledge Management and Sharing
- Glycogen Storage Diseases and Myoclonus
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
University of New Mexico
2013-2025
Second Xiangya Hospital of Central South University
2024
Shenzhen University
2023
Tsinghua University
2022
Tri-Service General Hospital
2021
Nagoya University
2018-2020
Shanghai Municipal Human Resources and Social Security Bureau
2011
First Affiliated Hospital of Fujian Medical University
2011
This research examines the effects, over time, of network embeddedness, on three organizationally based social outcomes. We argue that in a centralized, publicly funded but mixed sector health and human services network, an organization's structural embeddedness as measured by its centrality, will be related to trustworthiness, reputation, influence, rated other members, this relationship strengthen time system matures. also examine how service performance is evolution.
As examples of a state agents, this paper will present comparative analysis the evolution two community mental health networks that both have similar contracts from State Arizona and operate under same set rules. One these is governed by for-profit firm produces services directly buys them network nonprofit agencies. The other based with four separate to offer services. These are analyzed, using social analysis, at beginning system years later. mature compared new network. system. discusses...
Abstract This article is an examination of the effects network involvement, or structural embeddedness, on three organizationally based social outcomes. Specifically, we argue that in centralized, publicly funded networks organization's embeddedness will be related to its trustworthiness, reputation and influence, as rated by other members. Results from a survey health human service generally confirm our hypotheses suggest additional work topic.
This article examines a publicly funded mental health services network, focusing on the patterns of interaction in five resource-based subnetworks. We argue that structure network relationships can be explained by nature resources are at source interaction. Depending whether particular resource is tangible or tacit, subnetwork structures will differ predictable ways. found pattern interactions among organizations subnetworks appears to dependent controlling these (the Network Administrative...
This article is a longitudinal examination of publicly funded network health and human services organizations that provide to mentally ill adults. Data were collected at two points in time from single large U.S. metropolitan area: when the was completely reorganized, again it had matured, four years later. Analysis focuses on changes patterns interaction within across five resource‐based subnetworks. The authors argue structure relationships depends type resources involved—whether tangible...
Objectives Multiple sclerosis (MS) is a chronic inflammatory autoimmune and degenerative disorder of the central nervous system. Telomeres are protective structures located at ends linear chromosomes, leukocyte telomere length (LTL) closely connected with cell aging senescence. However, relationship between LTL risk MS remains unknown. Methods We performed two-sample Mendelian randomization (MR) to evaluate whether was causally associated risk. Results In our MR analysis, 12 LTL-related...
Abstract Sharing scientific and technical information plays a vital role in fostering more deliberate political dynamics within policy subsystems, according to the Advocacy Coalition Framework (ACF). However, obstacles this exchange are not well understood. Our research, guided by theories of social network embeddedness, explores how power imbalances relate reciprocal information. Using visualization quadratic assignment procedure multiple regression on data from local hydraulic fracturing...
Small cell lung cancer (SCLC) is a highly malignant characterized by metastasis and an extremely poor prognosis. Although combined chemoimmunotherapy improves the prognosis of extensive-stage (ES)-SCLC, survival benefits remain limited. Furthermore, no reliable biomarker available so far to predict treatment outcomes for chemoimmunotherapy.This retrospective study included patients with ES-SCLC treated first-line atezolizumab or durvalumab standard chemotherapy between Janauray 1, 2019...
Abstract This study investigates changes and continuity in the performance appraisal reward systems of four Chinese IT firms after they were acquired by US‐owned multinational corporations. Drawing on different perspectives, it examines units extent to which may be influenced interplay business strategy, organizational structure, resource‐based power acquiring partners, management competence, labor market factors, cultural norms China. The reveals that guiding principle policy have...
Objectives Physical activity (PA) is considered beneficial in slowing the progression and improving neurodegenerative disease prognosis. However, association between PA diseases remains unknown. In this study, we conducted a two-sample Mendelian randomization (MR) analysis to estimate causal phenotypes diseases. Materials methods Genetic variants robustly associated with phenotypes, used as instrumental variables, were extracted from public genome-wide study (GWAS) summary statistics....
Abstract Motivation: MicroRNA (miRNA) is a set of newly discovered non-coding small RNA molecules. Its significant effects have contributed to number critical biological events including cell proliferation, apoptosis development, as well tumorigenesis. High-dimensional genomic discovery platforms (e.g. microarray) been employed evaluate the important roles miRNAs by analyzing their expression profiling. However, because total and absence well-known endogenous controls, traditional...
Muscleblind-like 1 (MBNL1) is a ubiquitously expressed RNA-binding protein, which highly in skeletal muscle. Abnormally expanded CUG-repeats the DMPK gene cause myotonic dystrophy type (DM1) by sequestration of MBNL1 to nuclear RNA foci and upregulation another CUG-binding protein (CUGBP1). We previously reported that nonsteroidal anti-inflammatory drug (NSAID), phenylbutazone, upregulates expression DM1 mouse model demethylation MeR2, an enhancer element Mbnl1 intron 1. NSAIDs inhibit...
GNE myopathy is a heterogeneous group of ultrarare neuromuscular disorders caused by mutations in the gene. An estimated prevalence 1~21/1,000,000 leads to deficiency data and lack availability samples conduct clinical research on this disorder. Although GNE, which mutated gene responsible for disease, well known as key enzyme biosynthesis pathway sialic acid, clinicopathological-genetic spectrum mutant patients still unclear expanding. This study presents ten unrelated with myopathy,...
Multiple Acyl‐CoA dehydrogenase deficiency (MADD), one of the most common lipid storage myopathies (LSMs), is a heterogeneous inherited muscular disorder that pathologically characterized by numerous droplets in muscle fibers due to metabolism disturbance. MADD exhibits wide range clinical features, including skeletal weakness and multisystem dysfunctions. However, MADD, as well other types LSM, associated with peripheral neuropathy has rarely been reported during past four decades. Here, we...