A5100453326- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Nausea and vomiting management
- Autophagy in Disease and Therapy
- Anesthesia and Pain Management
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Geological and Geophysical Studies
- Radiopharmaceutical Chemistry and Applications
- Biochemical and Molecular Research
- interferon and immune responses
First Affiliated Hospital of Guangzhou Medical University
2024-2025
State Key Laboratory of Respiratory Disease
2024-2025
Guangzhou Medical University
2023-2025
Ningxia Medical University
2025
Nanjing Medical University
2015-2024
Nanjing General Hospital of Nanjing Military Command
2003-2024
Nanjing University
2015-2024
Macau University of Science and Technology
2022-2024
Chengdu Medical College
2024
Second Affiliated Hospital of Harbin Medical University
2024
Patients with metastatic gastric cancer (mGC) who do not respond to or experience progression second-line chemotherapy have no treatment options that clearly confer a survival benefit. This trial investigated the safety and efficacy of apatinib, an inhibitor vascular endothelial growth factor receptor, as option for heavily pretreated patients mGC.Patients experienced failure at least two chemotherapeutic regimens were randomly assigned receive placebo (group A), apatinib 850 mg once daily...
Although CircRNA_100269 is a biomarker used to predict cancer recurrence, its expression and function in gastric (GC) remain unknown.In this study, the of circRNA_100269 potential downstream miRNA targets were investigated.The molecular regulatory mechanism GC cell lines also elucidated.The levels linear isomer LPHN2 mRNA found be downregulated (p<0.01) tissues.The target was predicted miR-630, whose upregulated negatively correlated with that (r = -0.688) tissues.Moreover, direct...
Abstract Background Dysregulation of microRNAs (miRNAs) have been demonstrated to contribute carcinogenesis. MiR-143-3p has identified function as a tumor suppressor in several tumors, but the role miR-143-3p esophageal squamous cell carcinoma (ESCC) not intensively investigated. Our aim was evaluate potential progression ESCC. Methods The expression levels and QKI-5 protein were measured 80 resected ESCC specimens clinicopathological significance these determined. We also investigated...
Abstract Background Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of in colorectal cancer (CRC) metastasis and underlying mechanism are still largely unclear. Methods Use public database screen potential lncRNA crucial for cancer. The expression clinical CRC specimens detected by qRT-PCR. effect on cells investigated transwell, wound healing assays, CCK-8 assays animal studies. proteins binding were identified...
Exosomes released by tumor cells have been recently identified as important determinants of progression. They often carry circular RNAs that are differentially expressed in tumors and may regulate tumorigenesis metastasis. Here, we showed supernatant 97H hepatocellular carcinoma (HCC) cell line could promote metastasis L02 human liver HCC lines. Moreover, determined circ_MMP2 (has_circ_0039411) be delivered 97H- or LM3 cell-derived exosomes to HepG2 cultures. High expression led the...
Abstract Emerging evidence has revealed that aberrantly expressed circular RNAs (circRNAs) play vital roles in tumorigenesis and progression of diverse human malignancies. Although an existing literature elucidated the regulatory role circZNF609 breast cancer, crucial function exerted on hepatocellular carcinoma (HCC) remains unclear. Herein, we determined to explore molecular mechanism HCC. In this study, was conspicuously overexpressed featured with loop structure Functional tests...
Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment with artemisinin (AT) downregulates protein levels MMP3, MMP13, and ADAMTS5, which are degradation-related proteins in OA, inhibits expression inflammatory factors interleukin-1β (IL-1β)-stimulated chondrocytes. However, mechanism role AT OA remains unclear. Here, we performed gene sequencing bioinformatics...
Abstract It remains an obstacle to induce the regeneration of hard dentin tissue in clinical settings. To overcome this, a P(VDF‐TrFE) piezoelectric film with 2 wt% SrCl addition is designed. The biofilm shows high flexibility, harmonious biocompatibility, and large d 33 coefficient 14 pC N −1 , all contributing building electric microenvironment that favor recruitment dental pulp stem cells (DPSCs) their differentiation into odontoblasts during normal chewing, speaking, etc. On other hand,...
Circular RNAs are a large class of noncoding RNA that have shown huge capabilities as gene regulators. Recent evidence suggest circular associated with many diseases, especially cancer. However, little attention has been focused on the expression and function in gastric cancer (GC). In this study, we demonstrate circ-104916 is downregulated GC tissues cell lines. A lower appeared deeper invasion depth, higher tumor stage more frequent lymphatic metastasis patients. Overexpression effectively...
// Yan Zhang 1 , Jin Li Jiang Yu Hao Liu Zhiyong Shen Gentai Ye Tingyu Mou Xiaolong Qi Guoxin Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China Correspondence to: Li, email: gzliguoxin@163.com Qi, qixiaolong@vip.163.com Keywords: circular RNA, gastric cancer, prediction, recurrence Received: October 24, 2016 Accepted: January 22, 2017 Published: February 11, ABSTRACT Tumor is usually detected within one year after radical resection stage III...
Abstract Background Circular RNA (circRNA) is emerging as an important player in human diseases, especially cancer. In our previous study, we identified a series of deregulated circRNAs hepatocellular carcinoma (HCC) by performing circRNA microarray expression profile. Here, aimed to explore the role circ-LRIG3 (hsa_circ_0027345) HCC. Methods qRT-PCR and western blot were used asses gene protein expression, respectively. CCK-8, EdU Transwell assays detect cell proliferation, migration...
Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported involve in multiple cancers including Hepatocellular Carcinoma (HCC). Our previous study found that HBx, HBV encodes X protein, mediated H3K4me3 modification WDR5-dependent manner infection and contribute oncogene expression. AlkB Homolog 5 (ALKBH5), one of enzymes, identified be associated with cancers. However,...
Hepatocellular carcinoma (HCC) has been identified as one of the leading causes cancer-related death worldwide. Recently, long non-coding RNAs (lncRNAs) attract much attention researchers, and they are demonstrated to be dysregulated in a variety cancers, including HCC. LncRNA gastric high expressed transcript 1 lncRNA GHET1 is found cancer (GC). However, its clinical value potential biological function HCC remains unclear. In this study, expression level was analyzed 72 tissues matched...
MicroRNA-142-3p (miR-142-3p) is dysregulated in many malignancies and may function as a tumor suppressor or oncogene tumorigenesis development. However, few studies have investigated the clinical significance biological of miR-142-3p hepatocellular carcinoma (HCC).The expression levels taurine upregulated gene 1 (TUG1), miR-142-3p, zinc finger E-box-binding homeobox (ZEB1) were evaluated HCC tissues cell lines by quantitative real-time PCR. MTT colony formation assays used to detect...
Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and drug resistance. Tumor angiogenesis plays important role in development of gastric a challenge treatment cancer.Mouse xenograft models were used for screening therapeutic peptides on growth metastasis. Routine laboratory experimental methods including conditional cell culture, tube formation assay, qRT-PCR, Western blotting,...
Super-enhancers (SEs) have been recognized as key epigenetic regulators underlying cancer stemness and malignant traits by aberrant transcriptional control promising therapeutic targets against human cancers. However, the SE landscape their roles during head neck squamous cell carcinoma (HNSCC) development especially in stem cells (CSCs) maintenance remain underexplored yet. Here, we identify leukemia inhibitory factor (LIF)-SE a representative oncogenic to activate LIF transcription HNSCC....
<title>Abstract</title> <bold>Backgrounds:</bold> UDP-glucose 6-dehydrogenase (UGDH) is the key enzyme of glucuronic acid metabolism and a mediator in several cancer developmental signaling pathways. However, expression function UGDH colorectal (CRC) are unclear. <bold>Method:</bold>Bioinformatics analysis was conducted to research expression, diagnosis, prognosis, functional enrichment, genetic alterations, immune characteristics CRC. The gene knocked down HCT-8 cells. CCK8 cell wound...
Long non-coding RNAs (lncRNAs) are crucial molecules in tumorigenesis and tumor growth various human cancers, including colorectal cancer (CRC). Studies have revealed that lncRNAs can regulate cellular processes cancers by interacting with proteins, for example RNA-binding proteins (RBPs). In this study, we recognize a novel lncRNA called LINC01413 is upregulated CRC tissues through microarray. Subsequently, confirmed an elevated level of expression was strongly correlated to...