A5102973181- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Cytokine Signaling Pathways and Interactions
- Orthopedic Infections and Treatments
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- Hip and Femur Fractures
- Rheumatoid Arthritis Research and Therapies
- Pelvic and Acetabular Injuries
- Bone Metabolism and Diseases
- Pregnancy-related medical research
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Spinal Hematomas and Complications
- Medical Imaging and Analysis
- Inflammatory mediators and NSAID effects
- Systemic Lupus Erythematosus Research
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
Changzhou No.2 People's Hospital
2015-2024
Nanjing Medical University
2015-2024
Xuzhou Cancer Hospital
2020
Jiangsu University
2020
Jiangsu Province Hospital
2019
Jiaxing University
2019
Soochow University
2015
Fourth People's Hospital of Changzhou
2015
Osteoarthritis (OA) is one of the most painful and widespread chronic degenerative joint diseases characterized by destructed articular cartilage inflamed joints. Previously, our findings indicated that circular RNA ciRS-7 (ciRS-7)/microRNA 7 (miR-7) axis abnormally expressed in OA, regulates proliferation, inflammatory responses, apoptosis interleukin-1β (IL-1β)-stimulated chondrocytes. However, its underlying role OA remains unknown. In this study, we first validated degradation defection...
Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment with artemisinin (AT) downregulates protein levels MMP3, MMP13, and ADAMTS5, which are degradation-related proteins in OA, inhibits expression inflammatory factors interleukin-1β (IL-1β)-stimulated chondrocytes. However, mechanism role AT OA remains unclear. Here, we performed gene sequencing bioinformatics...
Abstract The cartilage repair and regeneration show inadequate self‐healing capability have some complications, which are inordinate challenges in clinical therapy. Biopolymeric injectable hydrogels, a prominent type of cell‐carrier as well tissue engineering scaffolding materials, establish promising therapeutic potential stem cell‐based cartilage‐regeneration treatment. In addition, biomaterial should rapid gelation properties with adequate rheological mechanical properties. the present...
Total hip arthroplasty (THA) is a vital therapy for various joint diseases. However, patients have lower hemoglobin level post-operatively, remarkably inconsistent with the measured blood loss. The inconsistence majorly attributed to hidden loss (HBL). In this study, we investigated HBL and its influential factors among after THA.From January 2008 June 2014, 322 (99 males 223 females) undergoing THA were enrolled in study. All assessed comprehensively before operation. demographic...
Cellular metabolic reprogramming is the main characteristic of cancer cells and identification targets using this pattern extremely important to treat cancers, such as osteosarcoma (OS). In study, SLIT2 ROBO1 were upregulated in OS, higher expression was associated with worse overall survival rate. Furthermore, vitro vivo experiments demonstrated that SLIT2/ROBO1 axis promotes proliferation, inhibits apoptosis, contributes Warburg effect OS cells. Mechanistically, exerted cancer-promoting...
Elevated levels of follistatin-like protein 1 (FSTL1) have been found both in mouse models for human rheumatoid arthritis (RA) and collagen-induced (CIA). In this study, we elucidated the potential mechanisms by which FSTL1 contributes to pathogenesis RA. Fibroblast-like synoviocytes (FLSs) were established from synovial tissues RA patients stimulated with recombinant FSTL1. Protein mRNA expression select matrix metalloproteinases (i.e., MMP1, MMP3, MMP13) FLS measured by, respectively,...
Objective To investigate the efficacy and safety of tranexamic acid (TXA) in reduction bleeding need for transfusion elderly intertrochanteric fracture patients. Methods A total 100 patients with fractures undergoing surgery were enrolled randomly allocated to TXA group which (75.10 ± 8.27 years old) treated 1 g TXA, or control (77.82 6.42 a placebo. Surgery was performed by two senior orthopaedic surgeons from institutions. The proximal femoral nail antirotation (PFNA) conducted using...
There is evidence that osteoarthritis (OA) associated with ferroptosis which a kind of lipid peroxidation-related cell death. Theaflavin-3,3 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M2"> <a:mo>′</a:mo> </a:math> -digallate(TF3), polyphenol compound extracted from black tea, possesses antioxidative and anti-inflammatory properties, but its effects on chondrocyte in remain unclear. Our present study aims at exploring the protective role underlying mechanisms TF3 against...
Follistatin-like protein 1 (FSTL1) is a proinflammation mediator implicated in arthritis rodent animal models. The present study aimed at assessing FSTL1 levels systemic autoimmune diseases and correlating them with disease activity patients rheumatoid (RA). Serum from 487 69 healthy individuals were measured by enzyme-linked immunosorbent assay (ELISA). expression synovial fluid (SF) tissues (STs) was determined ELISA, immunohistochemistry, real-time polymerase chain reaction (RT-PCR)...
Abstract Introduction Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been implicated in arthritis pathogenesis mouse model. The aim of this study to detect FSTL1 expression and further assess its potential utility as biomarker joint damage osteoarthritis (OA) patients. Methods was detected by real-time PCR, western blot immunohistochemistry (IHC) the synovial tissues (STs) IHC articular cartilage from OA patients control trauma serum fluid (SF) concentrations were...
Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response macrophage polarization state play essential roles in this osteolytic process. Harmine, a β-carboline alkaloid primitively extracted from Peganum harmala seeds, has been reported to have various pharmacological effects on monoamine oxidase action, insulin intake,...
Abstract The aim of this study is to observe the therapeutic effect percutaneous endoscopic discectomy and its influencing factors for lumbar disc herniation compare advantages disadvantages transforaminal interlaminar endoscopy. Data from 143 patients with were respectively collected, including demographic clinical data. Study population divided into curative group poor group, logistic regression was used explore effect. operation data pre-and post-operation scores compared approach on...
Altered expression levels of microRNA‑21 (miRNA‑21) have been observed in a series pathological processes, including cancer and central nervous system injury; however, the involvement miRNA‑21 molecular pathophysiology spinal cord injury (SCI) has not well documented. The present study examined its predicted target genes, programmed cell death 4 (PDCD4) phosphatase tensin homolog (PTEN), rats using quantitative polymerase chain reaction western blotting to further understand role mechanisms...
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed investigate the effects of ADAMTS5 polymorphisms on OA risk Chinese population. A total 300 patients and controls were recruited their genotypes rs226794 rs2830585 determined using custom-by-design 48-Plex single nucleotide polymorphism Scan™ kit. ADAMTS5-associated genes identified by co-expression analysis functions investigated...