A5064019332- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Hip disorders and treatments
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Orthopaedic implants and arthroplasty
- Protease and Inhibitor Mechanisms
- Intraperitoneal and Appendiceal Malignancies
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Biochemical and Molecular Research
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Cancer survivorship and care
- Total Knee Arthroplasty Outcomes
- Traditional Chinese Medicine Analysis
- Gastrointestinal Tumor Research and Treatment
- S100 Proteins and Annexins
Gansu University of Traditional Chinese Medicine
2021-2024
Hebei Medical University
2008-2024
Second Hospital of Hebei Medical University
2008-2024
Dalian Medical University
2023
People’s University
2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
First People's Hospital of Jingzhou
2023
Ferroptosis has been reported to play a role in rheumatoid arthritis (RA). Sulfasalazine, common clinical treatment for ankylosing spondylitis, also exerts pathological influence on the progression of including induced ferroptosis fibroblast-like synoviocytes (FLSs), which result perturbated downstream signaling and development RA. The aim this study was investigate underlying mechanism so as provide novel insight
There is evidence that osteoarthritis (OA) associated with ferroptosis which a kind of lipid peroxidation-related cell death. Theaflavin-3,3 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M2"> <a:mo>′</a:mo> </a:math> -digallate(TF3), polyphenol compound extracted from black tea, possesses antioxidative and anti-inflammatory properties, but its effects on chondrocyte in remain unclear. Our present study aims at exploring the protective role underlying mechanisms TF3 against...
Recent data support the role of S100A10 in tumorigenesis. In this study, we evaluated value positivity as a possible biomarker colorectal cancer. We by immunohistochemistry large population cancer patients (n = 882). The relationships between and clinicopathological features clinical outcome were analyzed. There 36 % (319/882) tumors positive for all samples. contrast, normal epithelium was negative among 562 specimens adjacent mucosa. correlated with poor differentiation (p 0.0012) disease...
To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with anal sphincter preservation for rectal cancer order to reduce cost operation, compare ES ultrasonically activated scalpel (US).Forty patients cancer, who underwent TME from June 2005 2007, were randomly divided into ultrasonic group group, prospectively. White blood cells (WBC) measured before after operative time, loss, pelvic volume drainage, time exhaust,...
Epidermal growth factor (EGF) plays an important role in tumorigenesis. The association between the +61 A/G polymorphism of EGF gene and colon cancer risk remains controversial unclear. objective this study was to investigate a Chinese population. A hospital-based case-control conducted assess possible risk. total 180 patients cancer-free healthy controls were recruited Genomic DNA isolated from peripheral blood, polymorphisms analyzed by polymerase chain reaction-restriction fragment length...
4538 Background: Gastric cancer remains the 3rd leading related death worldwide due to early disease recurrence. We hypothesize that hyperthermic intraperitoneal chemotherapy (HIPEC) may effectively prevent local regional recurrence for locally advanced gastric patients who received curative intent surgery. Methods: Pathology proven with clinical T3/T4NxM0 are eligible study and will be randomized either control group, receive standard radical gastrectomy D2 lymph node dissection or HIPEC...
Aim: This study aimed to verify the prognostic value of monocyte high-density lipoprotein ratio (MHR) in gastric cancer patients after radical resection. Methods: The Cox proportional hazards model was used determine risk variables for survival. Results: Older age (>60 years) (hazard [HR]: 1.832; 95% CI: 1.167–2.725; p = 0.009), advanced tumor node metastasis stage (p < 0.05), lymphatic invasion (HR: 1.639; 1.114–3.032; vascular 2.002; 1.246–5.453; 0.028) and high MHR 1.154; 1.062–2.315;...
Background: This retrospective cohort study aimed to evaluate the effect of lifestyle factors (e.g., smoking, drinking, physical exercise, and sleep duration) on long-term survival gastric cancer (GC) patients after radical resection. Materials Methods: GC resection were enrolled from January 2016 December 2017. Their baseline clinical data, factors, prognosis collected. The primary endpoint was all-cause death. relationship between variables examined using Cox proportional hazards model....
Abstract Background: Investigating the stabilizing impact of piriformis and conjoined tendons post-direct anterior total hip arthroplasty (DATHA) forms crux this study, given pertinence stability in postoperative outcomes long-term patient mobility. Methods: Utilizing 16 hips from 8 fresh frozen cadavers, study establishes two cohorts: tendon group group. A rigorous assessment involving simulated posterior dislocations post-DATHA was implemented, quantifying torque requisite for dislocation...
Abstract Background Osteoarthritis (OA) is one of the most common degenerative diseases. Accumulating evidence suggests that ferroptosis may be important in progression OA. Angelica Sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses antioxidative, anti-inflammatory and anti-apoptotic properties. However, it unclear whether ASP can slow down osteoarthritis by suppressing ferroptosis. Methods Collection postoperative joint cartilage from patients who underwent total knee...
Objective To investigate the potential antitumour effects of [2-(6-amino-purine-9-yl)-1-hydroxy-phosphine acyl ethyl] phosphonic acid (CP) against gastric adenocarcinoma. Methods Human BGC-823 xenotransplants were established in nude mice. Animals randomly divided into control and CP groups, which administered NaHCO3 vehicle alone or dissolved (200 µg/kg body weight) daily, respectively. Tumour volume was measured weekly for 6 weeks. Resected tumours assayed proliferative activity with...
Abstract Objective : Microsatellite instability (MSI) in gastric cancer contributes to genetic complexities of cancer. In the current study, we employed a panel mononucleotide and dinucleotide markers detect MSI 99 patients 91 chronic gastritis further analyzed association with clinicopathologic variables study patients. Methods We retrospectively data primary was using five microsatellite markers, including D2S12, D5S346, D17S799, BAT26, D18S34. defined as either band shift or appearance...
Abstract Osteoarthritis (OA) is one of the common degenerative diseases. Its main pathogenesis progressive destruction articular cartilage, synovitis, subchondral bone, and periarticular muscle changes. Accumulating evidence demonstrates that ferroptosis may be important in progression OA. Angelica Sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses antioxidative, anti-inflammatory anti-apoptotic properties chondrocytes. In this study, we observed participates OA’s...
Osteoarthritis (OA) pathogenesis involves inflammation, age, weight and other factors. Integrin-linked kinase (ILK) regulates cell apoptosis, metastasis, growth. However, whether ILK affects bone formation of marrow mesenchymal stem cells in an inflammatory environment has not been elucidated. Rat BMSCs were isolated assigned into control group, inflammation group (lipopolysaccharide was added to cells); si-ILK (ILK siRNA transfected the BMSCs) followed by analysis proliferation MTT assay,...