A5101852476- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Mycotoxins in Agriculture and Food
- Science, Research, and Medicine
- Inflammasome and immune disorders
- RNA modifications and cancer
- Restraint-Related Deaths
- Monoclonal and Polyclonal Antibodies Research
- Microfluidic and Capillary Electrophoresis Applications
- Curcumin's Biomedical Applications
- Traumatic Ocular and Foreign Body Injuries
- Cancer therapeutics and mechanisms
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- IL-33, ST2, and ILC Pathways
- Protease and Inhibitor Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial Natural Products and Biosynthesis
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Trauma Management and Diagnosis
- Cancer Treatment and Pharmacology
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Jilin Medical University
2019-2021
Hebei Medical University
2017-2021
Hebei General Hospital
2020
Curcumin enhances Ucp1-dependent thermogenesis to ameliorate high-fat diet-induced obesity through modulation of gut microbiota and bile acid metabolism.
The high heterogeneity of hepatocellular carcinoma (HCC) poses challenges for precision treatment strategies. This study aims to use multi-omics methodologies better understand its pathogenesis and discover biomarkers. Quantitative proteomics was used investigate tissues (HCT) their corresponding adjacent non-tumor (DNT), obtained from six HCC patients. Untargeted metabolomics applied analyze the metabolic profiles HCT DNT ten Statistical analyses, such as Student's t-test, were performed...
Based on the continuous exploration of solid tumor immunotherapy, we focused hepatocellular carcinoma with a high level morbidity and mortality. We confirm stability mcDNA-based CAR T cell generating platform, investigate antitumor activity CD44-CAR cells against both in vitro vivo.We fused anti-CD44 scFv structure transmembrane domain intracellular domain. Using non-viral mcDNA vector to load gene, then transfected mcDNA-CD44-CAR into human by electroporation. exhibited transfection...
T-2 toxin, produced by Fusarium moulds, is a type A trichothecene mycotoxin which known to inhibit protein synthesis and also reported induce DNA lesions, potentially causing fragmentation. toxin very potent cytotoxic displays anti-tumor properties. Nevertheless, more studies are still needed explore its antitumor mechanisms as well clinical application in cancer treatment. Here, we report the identification characterization of poae isolated from Jilin, Northeast China. 17 strains were...
D-dimer is an essential diagnostic index of thrombotic diseases. Since the existing anti-D-dimer antibodies vary in quality and specificity, a search for alternative required. The present study aimed to screen novel monoclonal antibody (mAb) against using light-initiated chemiluminescence assay (LiCA). In this work, mice were immunized with antigen prepared from human plasma by enzyme hydrolysis. After screening, mAb, DD 2G11, was obtained. results sodium dodecyl sulfate-polyacrylamide gel...
Abstract Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and adoptive immunotherapy which worth studying. CD133, a kind cancer stem cell (CSC) antigen, together with glypican-3 (GPC3) have been proved to be highly expressed in HCC cells both them are used as targets generate chimeric antigen receptor (CAR) T cells. But there limitations like “on-target, off-tumor” toxicity, low transfection efficacy weak antitumor ability CAR treatment. Methods: First...