A facile and efficient one-pot procedure for the preparation of functionalized dihydro-1H-indol-4(5H)-ones by a catalyst-free, three-component reaction 1,3-dicarbonyl compounds, arylglyoxal monohydrate enaminones under mild conditions in excellent yield is reported. This synthesis was confirmed to follow group-assisted-purification (GAP) chemistry process, which can avoid traditional purifications, chromatography, recrystallization.

A concise and efficient one-pot synthesis of pyrrolyl coumarin derivatives via a four-component reaction 4-hydroxycoumarin, arylglyoxal monohydrate, dialkyl but-2-ynedioate amines under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. This was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography recrystallization purification methods.

A Pd-catalyzed dual C-H carbonylation of commercially available diarylamines using Co

In this work, a charge conversion mechanism was introduced to build bacteria responsive antibacterial surface. The antimicrobial surface is constructed by immobilizing pH-responsive moieties on the of material, followed immobilization peptide (AMP) melittin (MLT) strong electrostatic interaction. exhibited self-defensive properties against Gram-positive and Gram-negative bacteria. comparison with previously reported systems side effects drug resistance, prevented undesirable resistance....

Abstract A Pd‐catalyzed formal [3+2] oxidative annulation of N ‐aryl‐2‐aminopyridines and alkynes through pyridyl group directed C−H activation has been developed. This methodology provides a mild atom‐economic approach for the efficient synthesis highly substituted indoles in moderate to good yields, which features with reaction conditions, functional compatibility, operational simplicity easy scale‐up.

Abstract A series of 4‐aryl‐3,7,7‐trimethyl‐1‐phenyl‐7,8‐dihydro‐1 H ‐pyrazolo[3,4‐ b ]quinolin‐ 5(6 )‐ones were synthesized by the three‐component reaction aromatic aldehydes, 3‐methyl‐1‐phenyl‐1 ‐pyrazol‐5‐amine, and 5,5‐dimethyl‐1,3‐cyclohexandione in presence sodium 1‐dodecanesulfonate aqueous medium. Compared to previous methods, this new protocol has advantages convenient operation, higher yields, lower cost, environmentally benign procedure. J. Heterocyclic Chem., (2012).

A facile construction of α-allylbutenolides from readily available allyl ynoates has been developed via tandem gold-catalyzed alkyne isomerization to allene and cycloisomerization, the Claisen rearrangement a double bond migration. The gold catalysis is enabled by bifunctional phosphine ligand featuring critical remote tertiary amino group, reaction tolerates range substituents exhibits yields up 96%.

A Pd-catalyzed carbonylative dearomatization via an acyl Pd complex has been developed. Diversified carbonyl-containing spirocyclic indolenines with all-carbon quaternary center were constructed in efficient and straightforward way good to excellent yields. The protocol features a simple catalytic system, operational simplicity, broad substrate scope, easy scale-up, versatile transformations. In addition, the asymmetric reaction was initially explored moderate enantioselectivity.

An inorganic-organic chemosensing material (MS-NSP) was developed by anchoring the bis-Schiff base fluorophore onto channel surface of a SBA-15 mesoporous silica with quaternary ammonium linker. The mesostructure, morphology, and spectral features MS-NSP were systematically described. nanohybrid could be implemented as multifunctional fluorescent nanosensor for Cu2+ ions. A good linearity observed over concentration range from 0 to 4 mM, lower detection limit found 0.19 μM. Additionally,...

Background Giardia lamblia is one of the most common infectious protozoans in human that may cause diarrhea travelers. Searching for antigens induced effectively protective immunity has become a key point development vaccine against giardiasis. Methodology/Principal Findings Mice vaccinated with G. trophozozite-specific α1-giardin DNA delivered orally by attenuated Salmonella typhimurium SL7027 elicited 74.2% trophozoite reduction, but only 28% reduction cyst shedding compared PBS buffer...

Biomedical device-associated infection (BAI) is one of the main reasons for function failure implants in clinical practice. Development high-efficiency antibacterial materials great significance reducing incidence BAI and prolonging as well alleviate suffering patients. In this work, a hierarchical polymer brush modified surface that can self-adapt to bacterial stimuli exhibiting synergistic activities was constructed, it consisted upper poly(sulfobetaine methacrylate) (pSBMA) brushes...

Abstract A Pd‐catalyzed carbonylative Heck reaction of 2‐iodophenyl alkenyl ether using Mo(CO) 6 as a safe CO source has been developed. This research provides an atom‐economic and straightforward route for the efficient construction benzofuran‐3(2 H )‐one scaffolds with C2 quaternary center in moderate to good yields, which features operational safety, functional group compatibility easy scale‐up.

2-(Pyridin-2-yl) aniline was designed as a new, removable directing group in promoting C–H amination mediated by cupric acetate.

Bacteria-induced infections have always been associated with various medical devices. The construction of an intelligent antimicrobial surface is important challenge. In this study, we report the a zwitterionic good biocompatibility under physiological conditions and which shows anti-adhesion effect on original bacteria. Once bacteria multiply, acidic environment initiated by will cause amide bond to break, can be rapidly converted cationic bactericidal surface. Confocal laser scanning...

An efficient, convenient Cu‐catalyzed formation of chromeno[4,3‐ c ]pyrazol‐4(1 H )‐ones is reported. In this atom economic process, readily available 3‐acylcoumarin hydrazone oxidative cyclized by direct C–N bond formation. Air has been successfully used as an oxidant, which important and environmental advantages. A broad scope hydrazones can be utilized in process.

With the rapid development of takeout food industry in recent years, amount non-degradable wastes such as packing boxes and plastic bags are increasing day by day, which leads to severe waste resources pollution environment. How deal with packaging have become a new problem online ordering also an important subject social sustainable development. The construction recycling chain is measure achieve wastes. But this process involves many stakeholders, government, enterprises, package...