A5100343075- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Bone fractures and treatments
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Inflammatory mediators and NSAID effects
- Hip and Femur Fractures
- Graphene and Nanomaterials Applications
- Apelin-related biomedical research
- Shoulder Injury and Treatment
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Shoulder and Clavicle Injuries
- Circular RNAs in diseases
- Kruppel-like factors research
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- MicroRNA in disease regulation
- Medical research and treatments
- Liver physiology and pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Plant-based Medicinal Research
- Laser-Ablation Synthesis of Nanoparticles
- Connective tissue disorders research
Changzhou No.2 People's Hospital
2011-2024
Nanjing Medical University
2018-2024
Henan Provincial People's Hospital
2018-2023
Zhejiang Chinese Medical University
2022-2023
Henan Provincial Eye Hospital
2018-2023
Zhengzhou University
2023
Shanghai First People's Hospital
2018
The First Affiliated Hospital, Sun Yat-sen University
2013
Sun Yat-sen University
2013
Osteoarthritis (OA) is one of the most painful and widespread chronic degenerative joint diseases characterized by destructed articular cartilage inflamed joints. Previously, our findings indicated that circular RNA ciRS-7 (ciRS-7)/microRNA 7 (miR-7) axis abnormally expressed in OA, regulates proliferation, inflammatory responses, apoptosis interleukin-1β (IL-1β)-stimulated chondrocytes. However, its underlying role OA remains unknown. In this study, we first validated degradation defection...
Standing posterior-anterior (PA) radiographs from our clinical practice show that the concave and convex ilia are not always symmetrical in patients with adolescent idiopathic scoliosis (AIS). Transverse pelvic rotation may explain this observation, or asymmetry be responsible. The present study investigated symmetry by examining volume linear measurements of two hipbones AIS. Forty-two female AIS were recruited for study. PA (covering thoracic lumbar spinal regions entire pelvis), CT scans...
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed investigate the effects of ADAMTS5 polymorphisms on OA risk Chinese population. A total 300 patients and controls were recruited their genotypes rs226794 rs2830585 determined using custom-by-design 48-Plex single nucleotide polymorphism Scan™ kit. ADAMTS5-associated genes identified by co-expression analysis functions investigated...
Doxorubicin (DOX) is an effective anticancer drug which widely used in clinical treatment. However, the severe cardiotoxicity limits its use. Thus, it urgent need to attenuate toxicity of DOX without impairing efficacy. Many studies show that Se may protect normal tissues from damages some drugs. Recently, Se@SiO2 nanocomposites emerges as better substitutes for direct element treatment cancer cells their ideal biocompatibility. In present article, we synthesized and confirmed...
Submassive hepatic necrosis (SMHN, defined as of 15-90% the entire liver on explant) is a likely characteristic pathological feature ACLF in patients with hepatitis B cirrhosis. We aimed to comprehensively explore microbiome and bile acids patterns across enterhepatic circulation build well-performing machine learning models predict SMHN status.Based presence or absence SMHN, 17 HBV-related end-stage disease who received transplantation were eligible for inclusion. Serum, portal venous...
Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of the articular cartilage or inflamed joints. Britanin guaiacyl-type sesquiterpene lactone possessing anti-inflammatory and antioxidant activities. In this study, western blotting, Reverse-transcription PCR (RT-PCR), immunofluorescent staining method were used to clarifying molecular mechanisms britanin in alleviating chondrocyte ferroptosis. The effect on reactive oxygen species (ROS) lipid peroxidation levels...
<strong>BACKGROUND</strong> Worldwide, the increasing use of antibiotics has resulted in antimicrobial resistance, leading to studies find alternative treatments. Tea polyphenols have antibacterial properties. Bacteriocins produced by probiotic lactobacilli can inhibit Gram-positive bacteria. This study used a rabbit model infection, following femoral fracture with internal fixation, evaluate efficacy combined tea and Lactobacillus plantarum ST8SH bacteriocin. <strong>MATERIAL AND...
Abstract An association of Matrix Metalloproteinases-1/3 (MMP-1/3) rs1799750/rs3025058 polymorphism with increased risk rotator cuff tear (RCT) has been reported in a Brazilian population. However, this significant not confirmed the Chinese Genotyping was conducted by polymerase chain reaction (PCR)-restriction fragment length and direct sequencing. Our results demonstrated that individuals TT genotype had significantly higher RCT compared those CC genotype. The progression associated 2G...
MiR-7 has been recognized as an osteoarthritis (OA-)-promoting factor, but the specific downstream pathway of miR-7 still remains unknown. Further investigation molecular regulatory mechanism might help develop a novel therapeutic method for OA. In this study, we revealed that Semaphorin 6D (SEMA6D) was direct target gene and presented negative relation with SEMA6D in vitro vivo. could improve OA rat models, indicated by H&E Safranin O-Fast green staining, also μCT analysis. evaluation...
BACKGROUND:This retrospective analysis was designed to compare the outcomes of mid-shaft clavicle fracture operative treatment using bridge combined fixation system (BCFS) versus clavicular locking plate (CLP). MATERIAL AND METHODS:Operative surgeries performed between January 2016 and July 2018 were included in analysis. The surgical internal implants chosen according surgeon preference choice patients BCFS CLP. Functional outcomes, union, complications, pain, patient satisfaction...
Purpose: To investigate the ocular pharmacokinetic properties of intravitreally injected aflibercept in rabbits after using brinzolamide 1%/timolol maleate 0.5% fixed-combination eye drops. Methods: The right 5 was topically administered 30 μL and timolol drops twice a day (q12h). 2 eyes each rabbit were with 1.0 mg (0.025 cc) on 2nd instilling intraocular pressure measured before injection sampling. aqueous humor drawn at 1, 3, 7, 14, 21, 28 days. Aflibercept concentrations vitreous (28...
The low bone mineral density due to abnormally activated osteoclasts can induce disorders such as osteopenia and osteoporosis. MiR-25-3p modulates sphingosine-1-phosphate receptor 1 (S1PR1) expression enhance osteoclast motivation. association between miR-25 rs41274221 polymorphism osteoporosis susceptibility is unknown. Herein, 300 patients with 320 healthy controls were genotyped using polymerase chain reaction Sanger sequencing explore the role of in odds ratios (ORs) 95% confidence...
Abstract Background: MiR-7 has been recognized as a promoting factor of osteoarthritis (OA), but the specific down-stream pathway miR-7 still remains unknown. Further investigation molecular regulatory mechanism might help develop novel therapeutic method for OA. Results: Here we revealed that Semaphorin 6D (SEMA6D) was direct target gene miR-7, which presented negatively relation in vitro and vivo. Lucubration SEMA6D suggested is validated to promote anabolic metabolism reduce catabolism...
Medication safety is one of the primary considerations in drug therapy.With increase categories and diversification delivery routes, more attention has been paid to ocular adverse events caused by topical systemic administration.Topical administration can directly induce toxicity eye tissues.After administration, especially long-term drugs may permeate blood-ocular barrier cause toxic effects on anterior segment posterior eye.In this article, we reviewed reports studies most commonly...
Objective To investigate the clinical features and therapeutic effects of acute craniocerebral trauma in infants children under 10 years old. Methods A retrospective analysis 130 cases with cranial injury old from January 2016 to 2018 was conducted. Among them, 72 were males 58 females, average age (4.12±0.63) years. The mechanisms, types, treatment methods prognosis analyzed. divided into two groups: 0~5 group 6~10 group. characteristics groups analyzed, differences mechanism, type...
Objective To evaluate composite bridge internal fixation in the treatment of limb metaphyseal fractures children. Methods From October 2015 to December 2018, 16 children was treated by for at Department Orthopaedics, The Second People's Hospital Changzhou. They were 11 boys and 5 girls, aged from 8 14 years (average, 11.0 years). Their located proximal humerus 4 cases, distal femur 3 tibia cases 6 cases. According Salter-Harris classification, type Ⅱ, Ⅲ Ⅳ. time injury surgery ranged...