A5101679956- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Ecology and Vegetation Dynamics Studies
- Ocular Infections and Treatments
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Antibiotics Pharmacokinetics and Efficacy
- Forest ecology and management
- Animal Ecology and Behavior Studies
- Plant Water Relations and Carbon Dynamics
- Glaucoma and retinal disorders
- Plant and animal studies
- Advanced Polymer Synthesis and Characterization
- Ecosystem dynamics and resilience
- Photodynamic Therapy Research Studies
- Forest Ecology and Biodiversity Studies
- Corneal Surgery and Treatments
- Leaf Properties and Growth Measurement
- Essential Oils and Antimicrobial Activity
- Architectural and Urban Studies
- Ocular Diseases and Behçet’s Syndrome
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Plant and Fungal Species Descriptions
Wuhan Botanical Garden
2020-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2020-2024
Henan Provincial Eye Hospital
2012-2023
Henan Provincial People's Hospital
2013-2023
Zhengzhou University
2010-2023
Chengdu Institute of Biology
2023
University of Göttingen
2022
Propagation des Ondes : Étude Mathématique et Simulation
2022
Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration Jingguo Li, Zhanrong Tianyang Zhou, Junjie Zhang, Huiyun Xia, Heng Jijun He, Siyu Liya Wang Henan Eye Institute, Hospital, Provincial People’s Hospital and Zhengzhou University Zhengzhou, People’s Republic of China Purpose: The cornea is main barrier to drug after topical application. aim this study was evaluate the abilities generated from positively penetrate Methods:...
Non-ionic surfactant micelles are helpful for improving the diffusion of topically delivered drugs through cornea. This study aimed to develop terbinafine hydrochloride (TH)-loaded based on a soft non-ionic surfactant-macrogol 15 hydroxystearate (HS 15) and investigate their in vivo cornea permeation. Briefly, 0.25% TH-loaded HS (TH-HNMs) were developed using simple co-solvent method. Characterization TH-HNMs by Zetasizer transmission electron microscopy (TEM) revealed that spherical...
Fungal keratitis (FK) remains a severe sight-threatening disease, and case management is difficult due to ocular intrinsic barriers drug shortages. Econazole (ECZ), broad-spectrum antifungal agent, limited in applications the poor water solubility strong irritant property.We successfully prepared solid-lipid nanoparticle-based ECZ eye drops (E-SLNs) by microemulsion method, physicochemical properties of E-SLNs were investigated. Corneal permeability, ability against Fusarium spp., irritation...
Luliconazole (LCZ), a novel imidazole drug, has broad-spectrum and potential antifungal effects, which makes it possible cure for fungal keratitis; nevertheless, its medical use in ocular infections is hindered by poor solubility. The purpose of this study was to design optimize LCZ nanoemulsion (LCZ-NE) formulations using the central composite design-response surface methodology, investigate improving bioavailability following topical administration. LCZ-NE formulation composed Capryol 90,...
Fungal keratitis is an infectious disease caused by pathogenic fungi with a high blindness rate. Econazole (ECZ) imidazole antifungal drug insoluble ability. Econazole-loaded solid lipid nanoparticles (E-SLNs) were prepared microemulsion method, then modified positive and negative charge. The mean diameter of cationic E-SLNs, nearly neutral E-SLNs anionic 18.73±0.14, 19.05±0.28, 18.54±0.10 nm respectively. Zeta potential these different charged SLNs formulations 19.13±0.89, -2.20±0.10,...
Fungal keratitis (FK) is a serious infectious corneal disease that leads to blindness. Butenafine (BTF) an allylamine drug with high antifungal activity, but its poor water solubility and low bioavailability limit clinical application in ophthalmology. To increase aqueous permeability, butenafine was encapsulated d-ɑ-tocopheryl polyethylene glycol succinate (TPGS) polymeric nanomicelles improve the of for treatment FK. successfully fabricated into EE 96.34 ± 1.65 % DL 6.71 0.099 %. The...
Vorinostat (suberoylanilide hydroxamic acid, SAHA), an FDA-approved drug for cutaneous T cell lymphoma, has antiangiogenic and anti-inflammatory activity thus therapeutic potential inflammatory corneal neovascularization (CNV). However, its practical administration is limited due to poor aqueous solubility permeability. This study aimed enhance the permeability of SAHA by promoting inclusion into a complex with hydroxypropyl-β-CD (HPβCD) topical application. In phase-solubility studies,...
Abstract Foundation species structure forest communities and ecosystems but are difficult to identify without long‐term observations or experiments. We used statistical criteria––outliers from size‐frequency distributions scale‐dependent negative effects on alpha diversity positive beta diversity––to candidate foundation woody plant in 12 large forest‐dynamics plots spanning 26 degrees of latitude China. these data (1) Chinese forests, (2) test the hypothesis––based a midlatitude peak...
Slope aspect can cause environmental heterogeneity over relatively short distances, which in turn affects plant distribution, community structure, and ecosystem function. However, the response adaptation strategies of plants to slope aspects via regulating their physiological morphological properties still remain poorly understood, especially alpine ecosystems. Here, we selected four common species, including Bistorta macrophylla, vivipara, Cremanthodium discoideum, Deschampsia littoralis,...
Purpose: To evaluate the aqueous humor pharmacokinetics of a preservative-free 0.005% latanoprost unit-dose eye drop (test drug) compared with that benzalkonium chloride (BAK)-preserved branded product (control following topical application to rabbits. Methods: A total 120 healthy New Zealand albino rabbits were administrated test drops (T group) or control (C for comparative study. The was collected at 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 h after single dose multiple doses....
Purpose: To evaluate the ocular pharmacokinetics of clarithromycin (CLA) eye drops topically applied to corneas rabbits. Methods: One 50-μL drop CLA (0.25%) was administered each New Zealand white rabbit in a single dose group, and one 6 times at 5-min intervals loading group. The effect debridement on corneal penetration also investigated de-epithelium drug concentrations cornea aqueous humor (AH) were assayed using high-performance liquid chromatography with tandem mass spectrometry...
Aim Wuling Mountains range from the northeast to southwest in Central China, a region with high habitat complexity and diversity that supports substantial plant species diversity. Connecting northern subtropics mid-subtropics, also link floras of Eastern South-Western China. Despite long-standing interest how important role play exchange, patterns their underlying drivers are still not well characterized. Here, spatial distribution woody this is described structuring biodiversity surrounding...
From supporting wood production to mitigating climate change, forest ecosystem services are crucial the well-being of humans. Understanding mechanisms that drive dynamics can help us infer how maintain and improve predictions under change. Despite growing number studies exploring above ground biomass (AGB) dynamics, questions in biodiversity individuals still remain unclear. Here, we first explored patterns community different aspects (i.e., AGB, density biodiversity) based on short-term...
Luliconazole (LCZ) is a novel antifungal imidazole with broad-spectrum and high susceptibility of Aspergillus Fusarium are the dominant species fungal keratitis, may potentially be new medical treatment option for ocular infection. To evaluate LCZ distribution in tissues after topical application development ophthalmic delivery system, it important to have bioanalytical method measuring drug concentrations different aqueous humor (AH). A selective sensitive ultrahigh performance liquid...
Purpose: To investigate the ocular pharmacokinetic properties of intravitreally injected aflibercept in rabbits after using brinzolamide 1%/timolol maleate 0.5% fixed-combination eye drops. Methods: The right 5 was topically administered 30 μL and timolol drops twice a day (q12h). 2 eyes each rabbit were with 1.0 mg (0.025 cc) on 2nd instilling intraocular pressure measured before injection sampling. aqueous humor drawn at 1, 3, 7, 14, 21, 28 days. Aflibercept concentrations vitreous (28...
AbstractIn vitro studies, the efficacy of polyethylenimine(PEI) coupled ASODNs nanoparticles (PEI/ASODN) was compared with that traditional (non-coupling) delivery system against hTERT in esophageal squamous cancer cells (EC9706). The result showed PEI/ASODN uptake by EC9706 significantly higher than ASODN; growth rate transfected for lower ASODN. Nanoparticles PEI/ASODN, but not ASODN, abrogated expression mRNA and protein, also induced apoptosis cells. In vivo without NGR(PEI/ASODN or...
To evaluated the ocular pharmacokinetics of carnosine (CAR, a biologically active dipeptide which occurs naturally throughout human body) 5% eye drops following topical application.CAR were topically applied repeatedly (50 μL × 4) at an interval 5 min. Aqueous humor and lens collected after 5, 15, 30, 45, 60, 90, 120, 150, 180 CAR concentration was determined by high performance liquid chromatography-tandem quadrupole mass spectrometer (HPLC-MS/MS).CAR in treated eyes significantly higher...
Previous studies have shown that the extensive green roof (EGR) can serve to retain rainwater and mitigate runoff, but most of were in temperate zone. Located hot rainy subtropical zone, Guangzhou(GZ) is one China's earliest cities promote vertical greening, yet researches on EGR recent years focus more cooling effect, substrate screening selection tests, than mitigation runoff. For this study, three test platforms set up GZ EGRs with thicknesses 30mm, 50mm 70mm summer higher concentration...