A5100749828- Ocular Infections and Treatments
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Antifungal resistance and susceptibility
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Traditional Chinese Medicine Analysis
- Photodynamic Therapy Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Advanced Drug Delivery Systems
- Protease and Inhibitor Mechanisms
- Intimate Partner and Family Violence
- Bee Products Chemical Analysis
- Advanced Optical Sensing Technologies
- Retinopathy of Prematurity Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- COVID-19 epidemiological studies
- Pigment Synthesis and Properties
- Diet, Metabolism, and Disease
- Ginseng Biological Effects and Applications
- Ocular and Laser Science Research
Qiqihar University
2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Henan Provincial People's Hospital
2008-2024
Zhengzhou University
2013-2024
Henan Provincial Eye Hospital
2011-2024
Henan University
2018-2024
Shenzhen Nanshan Center for Chronic Disease Control
2023
Second Affiliated Hospital of Guangzhou Medical University
2008
Guangzhou Medical University
2008
To investigate the epidemiology, risk factors, fungal spectrum and to test antifungal drug susceptibility of these isolates at a tertiary eye care referral centre in central China.The medical microbiology records 2064 culture-proven cases (2064 eyes) keratitis diagnosed Henan Eye Institute between January 2000 March 2009 was retrospectively reviewed. The were identified subgroup 103 subjected tests for amphotericin B, fluconazole ketoconazole by broth microdilution method.A total confirmed...
Abstract Fusarium proliferatum ( F. ) is known as a pathogen of corn and other crops, but its role in fungal keratitis has not been well investigated. Among 877 isolates, we identified 155 (17.7%) stains according to their morphological features partial DNA sequencing translation elongation factor- $$1\alpha $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mn>1</mml:mn> <mml:mstyle> <mml:mo>α</mml:mo> </mml:mstyle> </mml:math> (EF- this study. In vitro antifungal...
In this paper, we study a diffusive SIS epidemic model with logistic source, saturation rate, and spontaneous infection mechanism. Based on the uniform bounds of parabolic system, global attractivity endemic equilibrium is established in homogeneous environment. Moreover, prove existence via topological degree theory. We mainly analyze effects dispersal, saturation, limiting behaviors equilibrium. These results show that source can enhance persistence infectious disease, causing disease to...
Fungal keratitis is one of the major causes visual impairment worldwide. However, effectiveness corneal collagen cross-linking (CXL) for fungal remains controversial. In this study, we developed an in vitro and vivo models to assess efficacy CXL Fusarium keratitis.The effect fungicidal was evaluated on cultures solani which were exposed irradiation different durations. Viability appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin nm). Each batch...
The effects of soy isoflavone (SIF) on insulin sensitivity and adipocytokines in high-fat-diet-induced resistant (IR) rats were studied. Male Sprague Dawley (n = 80) randomly assigned into a basal diet fed group high-fat group. IR model control three SIF-treated groups with different dosages. Thirty days later, the fasting blood glucose, serum mRNA expressions perirenal white adipose tissue measured. Homeostasis Model Assessment was calculated. administration 450 mg kg(-1) d(-1) SIF...
The role of mast cells (MCs) in fungal infection is largely unknown. This study was to explore a protective and mechanism MCs keratitis. Experimental keratitis (FK) mouse model developed. Mice untreated (UT) or receiving corneal wound without (Mock) were used as controls. Large number connective tissue found normal mice. MC activation with degranulation observed, the percentage degranulated/total high FK. Dilated limbal vasculature increased permeability, well infiltrated neutrophils...
Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline discovery of new antibiotics, antimicrobial drugs are now required. In present study, we determined antibacterial activity diacerein, anti-inflammatory drug, against 76 Gram-positive cocci isolated from bacterial patients vitro anti-Staphylococcus aureus mouse model vivo The MICs diacerein were tested using broth microdilution method A BALB/c Staphylococcus animal...
Dysregulated host response is an important cause of critical illness. Coagulation reaction the most primitive and can be used to assess patient status. reactions may amplified in very old patients (VOPs). This study aimed demonstrate coagulation critically ill VOPs by linking cytokines, coagulation, fibrinolytic processes. We analyzed 33 admitted our hospital, with average age 91.97. Laboratory test results were collected double checked. In-hospital mortality, Intensive Care Unit (ICU) stay,...
Coronary heart disease (CHD) is the leading cause of mortality worldwide. The Chinese medicinal formula Guanxin II has been shown to have a favorable effect in attenuation angina. aim this study was compare pharmacokinetics ferulic acid (FA), which vasorelaxant compound present II, healthy volunteers and patients with angina pectoris following administration II. Ex vivo experiments were performed order investigate FA on human internal mammary artery (IMA) provide evidence that it bioactive...
Purpose: To evaluate the ocular pharmacokinetics of clarithromycin (CLA) eye drops topically applied to corneas rabbits. Methods: One 50-μL drop CLA (0.25%) was administered each New Zealand white rabbit in a single dose group, and one 6 times at 5-min intervals loading group. The effect debridement on corneal penetration also investigated de-epithelium drug concentrations cornea aqueous humor (AH) were assayed using high-performance liquid chromatography with tandem mass spectrometry...
Purpose: To measure the cell size and density in five layers of central cornea widely used inbred C57BL/6 mouse strain using vivo three-dimensional (3D) two-photon (2PH) imaging.Methods: Corneas were scanned a 2PH laser scanning fluorescence microscope after staining with plasma membrane stain Hoechst 33342. Good quality 3D images selected for analysis. Cell was determined by counting nuclei predefined cube images. measurements, including surface area, volume, nuclear area automatically...
Introduction The incidence and prevalence of disability cognitive impairment, which are age-related, increase as China has become an ageing society. This study aims to establish the Shenzhen Ageing Cohort Study (SZ-ageing) explore epidemiological situation, risk factors biomarkers impairment among Chinese elderly individuals. Methods About 3000 participants aged 65 years older be recruited from communities in by using a multistage sampling method. They will receive baseline investigation...
Background Infective keratopathy is a key cause of corneal blindness in China,and fungal keratitis proved to have higher incidence and bigger threats infective keratitis.Researches showed that topical immunology plays an important effect during the development keratitis,but its mechanism still studying.Objective This experiment was explore critical immunocyte process keratitis.Methods Forty-eight SPF 12-week-old male C57BL/6J mice were included randomized into control group model group.The...
Objective To investigate the imaging manifestations of different filamentous fungal strains under confocal laser scanning microscope and slit-lamp microscope, evaluate feasibility rapid diagnosis therapeutic efficacy judgment for culture negative patients. Methods A trail was performed.Nine hundred ninety-three patients with keratitis (FK) which were varified by included in Henan Eye Hospital from September 2013 to January 2014.Distribution fungi positive rate corneal microscopy...