<h3>BACKGROUND AND PURPOSE:</h3> Braided self-expandable stents and flow diverters of uniform construction may develop zones heterogeneous porosity in vivo. Unwanted stenoses also occur at the extremities device. We studied these phenomena dedicated benchtop experiments. <h3>MATERIALS METHODS:</h3> Five braided devices decreasing were studied. To simulate discrepancies diameters between landing parent vessel aneurysm neck area, device inserted into silicone tubes various (2–3 mm), leaving...

Flow diverters (FDs) are increasingly used to treat complex intracranial aneurysms, but preclinical studies that could guide clinical applications lacking. The authors designed a modular aneurysm model in canines address this problem.Three variants of one were constructed 21 animals. Sidewall (n=5), curved sidewall and end-wall bifurcation (n=7) aneurysms treated with prototype 36-wire FDs. Four more 48-wire lower-porosity Angiographic results postimplantation at 3 months scored an ordinal...

<h3>BACKGROUND AND PURPOSE:</h3> FDs are new intracranial stents designed to occlude aneurysms while preserving flow jailed arterial branches. We tested this fundamental principle in a aneurysm model. <h3>MATERIALS METHODS:</h3> Canine lateral wall aneurysms, featuring branch located immediately opposite the aneurysm, were created 16 animals study effects on or occlusion using single HP (<i>n</i> = 4), 2 overlapping an FD 8). Two other animals, which efferent was anastomosed fundus, also...

Haemorrhagic complications can occur following aneurysm treatment with flow diverters (FD), but the underlying mechanism remains unknown. We describe a case where deformation of device may have contributed to complication. A patient giant, previously unruptured cavernous that extended intracranially cause oedema internal capsule was treated diversion. Treatment followed by multiple episodes peri-aneurysmal haemorrhages within eight days. which occurred it curved cross neck created residual...

Endovascular treatment of cerebral aneurysms, a minimally invasive alternative to surgery, is too often followed by recanalization and recurrences. The purpose this work was assess if in situ beta radiation can inhibit after coil embolization.Radioactive platinum coils (32P-coils) were produced ion implantation 32P. A single-coil arterial occlusion model used compare angiographic pathological results at 1 12 weeks nonradioactive 32P-coil embolization maxillary, cervical, vertebral arteries...

<b>BACKGROUND AND PURPOSE:</b> Endovascular treatment of aneurysms may result in complete or incomplete occlusions be followed by recurrences. The goal the present study was to better define pathologic features associated with so-called healing recurrences after coiling and propose an alternative concept currently accepted view. <b>MATERIALS METHODS:</b> Experimental canine venous pouch were created using a T-type (group A, <i>N</i> = 29) Y-type constructed bifurcation B, 37) between carotid...

<h3>BACKGROUND AND PURPOSE:</h3> The relationship between aneurysm dimensions, flow, thrombosis, and rupture remains poorly understood. We attempted to clarify this by exploring various swine models. <h3>MATERIALS METHODS:</h3> Bilateral carotid aneurysms were constructed according 3 protocols in 24 animals: small with wide necks (group 1; <i>n</i> = 6 animals); 2; 4 animals), giant large 3; 14 animals). Group included subgroups, related testing the model experimental conditions: neck was...

Endovascular treatment can improve the outcome of patients treated for ruptured intracranial aneurysms as compared with surgical clipping, but angiographic recurrences are frequent. Endothelial denudation before coil embolization may prevent recanalization and results endovascular treatment.We pathological 3 months after occlusion paired canine arteries (n=16), or without previous endothelial lining using an device. The technique was then used to denude neck carotid venous pouch bifurcation...

We thank Sherif and Plenk for their careful reading of our work thoughtful comments. They gave us an occasion to read more recent material from laboratory, which unfortunately could not be included in review, was limited 1961–2008. are also grateful have the

<h3>BACKGROUND AND PURPOSE:</h3> Endovascular treatment of wide-neck bifurcation aneurysms often results in incomplete occlusion or aneurysm recurrence. The goals this study were to compare coil embolization with without the assistance self-expandable stents and examine how may influence neointima formation. <h3>MATERIALS METHODS:</h3> Wide-neck constructed 24 animals and, after 4–6 weeks, randomly allocated 1 5 groups: 1) using braided stent (<i>n</i> = 5); 2) 2 a Y configuration 3) 6); 4)...

Flow diverters (FDs) are increasingly used for complex intracranial aneurysms. As these self-expanding devices deployed across an aneurysm neck, they can undergo deformations. The potential clinical consequences of FD deformations remain unclear. We describe immediate thrombotic complication attributed to a stereotypical stenotic deformation extremity that occur when landing zones insufficient length. This case is supplemented with in vitro studies showing the relationship between i) length...

Flow diverters (FDs) are increasingly used for bifurcation aneurysms. Failure of aneurysm occlusion may be caused by residual flow maintaining patency the jailed branch along with aneurysm. Our aim was to test whether endovascular could improve efficacy diversion aneurysms.Sixteen wide-necked lingual-carotid artery aneurysms were created in eight canines. Patent randomly allocated 4 weeks later combined using coils and/or Onyx (n=6) or alone (n=8). Angiographic results at 3 months scored an...

<h3>BACKGROUND AND PURPOSE:</h3> FDs are the latest, most promising tool to treat giant and complex aneurysms. Currently available experimental aneurysm models do not reproduce potential clinical difficulties of treating these lesions with FDs. <h3>MATERIALS METHODS:</h3> Six large or canine fusiform aneurysms were created on distal carotid arteries 4 animals. Four had multiple arterial branches originating from aneurysm; 2 other all clipped at time construction. Aneurysms treated...

Background and Purpose — We sought to investigate the role of endothelial lining in aneurysmal persistence recurrence after endovascular treatment aneurysms. Methods Bilateral venous pouch canine carotid aneurysms were studied by angiography pathology 1, 2, 3 weeks intraoperative collagen sponge embolization, coated or not with fibrinogen (n=15). In 12 dogs one aneurysm was removed before results compared a control bilateral embolization. 4 animals embolization covered endothelium...