A5103164569- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Plant Genetic and Mutation Studies
- Metastasis and carcinoma case studies
- Telomeres, Telomerase, and Senescence
- Sepsis Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Liver Disease and Transplantation
- CRISPR and Genetic Engineering
- Bioactive natural compounds
- Genetically Modified Organisms Research
- Molecular Biology Techniques and Applications
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Venous Thromboembolism Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Pancreatic and Hepatic Oncology Research
- Peanut Plant Research Studies
- Genomics and Phylogenetic Studies
- Sesame and Sesamin Research
- RNA Interference and Gene Delivery
- Traditional and Medicinal Uses of Annonaceae
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Tianjin Nankai Hospital
2016-2024
Second Affiliated Hospital of Zhejiang University
2020
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2018
Fred Hutch Cancer Center
2011-2013
The majority of cancer stem cells exist in the G0, or quiescent phase cell cycle. However, can escape quiescence following routine radiotherapy and chemotherapy, resulting tumor recurrence. Presently, achieving accurate regulation growth order to study a specific state, including (mostly G0 G1 phase), proliferative S phase) differential G2/M states, be challenging. This makes determination cycle state-specific characteristics analysis potential intervention treatments difficult, particularly...
Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the assumption that genes are conserved across mammalian species and hence inform human carcinogenesis, numerous investigators have used genetic linkage studies rats identify responsible for differential Using a backcross between resistant Copenhagen (Cop) susceptible Fischer 344 (F344) strains, we mapped novel carcinoma (Mcs30) locus centromeric region on chromosome 12 (LOD score of ∼8.6 at D12Rat59...
Background: Obstructive Jaundice (OJ) is a common clinical condition with potential outcomes, including hepatocyte necrosis, bile duct hyperplasia, significant cholestatic liver fibrosis, and, in severe cases, failure. Resveratrol (RES), polyphenol present grapes and berries, has demonstrated efficacy improving OJ. However, the precise mechanism of its action remains unclear. Methods: In this study, we employed network pharmacology to investigate underlying molecular RES treatment The...
Dysregulated host response is an important cause of critical illness. Coagulation reaction the most primitive and can be used to assess patient status. reactions may amplified in very old patients (VOPs). This study aimed demonstrate coagulation critically ill VOPs by linking cytokines, coagulation, fibrinolytic processes. We analyzed 33 admitted our hospital, with average age 91.97. Laboratory test results were collected double checked. In-hospital mortality, Intensive Care Unit (ICU) stay,...
The combination approach is now a well-established treatment for cancer. present study evaluated the potential of curcumin and resveratrol on p53 post-translational modifications during gastric We segregated rats into five groups that included normal controls, dimethylhydrazine (DMH) treated, DMH + treated. Morphological analyses tumor nodules confirmed carcinogenesis in after 25 weeks administration. significantly induced carcinogenesis, as evidenced by high burden DMH-treated compared with...
Analysis of the change cells in bile is an evolving research field biliary pathophysiology and has potential value diagnosis therapy. However, laboratory studies cell across world are scarce. Bile was collected from clinical patients with cholangiocarcinoma (CC). To optimize separation method CC, we studied factors that may affect vitality including dilution buffer, centrifugal force, time, store time temperature. Then these were modified performance evaluated by flow cytometry respect to...
Abstract Using Quantitative Trait Locus (QTL) mapping in a backcross between susceptible Fischer 344 and resistant Copenhagen rat strains, we identified Fry, the ortholog of Drosophila melanoganster furry gene, as mammary carcinoma susceptibility (Mcs) gene. The Fry allele harbors two single nucleotide polymorphisms that alter amino acid residues are highly conserved from yeast to humans. One these SNPs replaces an Alanine with Serine residue, creating de novo concensus sequence for several...