Qian Chen

ORCID: 0009-0008-0770-7101
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About
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Research Areas
  • Advanced biosensing and bioanalysis techniques
  • Biosensors and Analytical Detection
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Machine Learning in Bioinformatics
  • DNA and Nucleic Acid Chemistry
  • Bacteriophages and microbial interactions
  • Meat and Animal Product Quality
  • Advanced Nanomaterials in Catalysis
  • Polyamine Metabolism and Applications
  • Advanced Fluorescence Microscopy Techniques
  • Electrochemical Analysis and Applications
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Curcumin's Biomedical Applications
  • Glycosylation and Glycoproteins Research
  • Food Chemistry and Fat Analysis
  • bioluminescence and chemiluminescence research
  • Protein Hydrolysis and Bioactive Peptides
  • Viral Infectious Diseases and Gene Expression in Insects
  • Proteins in Food Systems
  • Studies on Chitinases and Chitosanases
  • Retinal Development and Disorders
  • CRISPR and Genetic Engineering
  • Advanced Cellulose Research Studies
  • Amino Acid Enzymes and Metabolism
  • ATP Synthase and ATPases Research

Anhui University of Technology
2021-2024

Fuzhou University
2019-2023

Northeast Agricultural University
2022-2023

Shanghai Ocean University
2020-2022

Jiangsu Normal University
2019

City of Hope
2018

Cancer Genetics (United States)
2018

McGovern Institute for Brain Research
2012

Massachusetts Institute of Technology
2012

Methicillin-resistant Staphylococcus aureus (MRSA) exhibits multiresistance to a plethora of antibiotics, therefore, accurate detection methods must be employed for timely identification facilitate effective infection control measures. Herein, we construct high-efficiency ratiometric electrochemiluminescent (ECL) biosensor that integrates multiple exonuclease (Exo) III-assisted cyclic amplification units rapid trace amounts MRSA. The target bacteria selectively bind the aptamer, triggering...

10.1021/acs.analchem.3c05410 article EN Analytical Chemistry 2024-01-02

Several circulating miRNAs are associated with the pathogenic process of acute myocardial infarction (AMI). Thus, analyzing in circulatory system is important for diagnosis and treatment AMI, especially early-stage diagnosis. Based on characteristics miRNAs, an ultrasensitive multitargeted electrochemiluminescence (ECL) sensing platform was developed a versatile probe that can couple DNAzyme hybridization chain reaction amplification. The target miRNA auxiliary chains form circular unit...

10.1021/acs.analchem.1c01051 article EN Analytical Chemistry 2021-05-04

Many studies have demonstrated that the extracellular domain of human epidermal growth factor receptor 2 (HER2 ECD) level in serum can act as a breast cancer biomarker and serve monitoring neoadjuvant therapy cancer. In this study, we developed sensitive ascorbic acid (AA)-mediated AuNBPs (gold nanobipyramids) method with NADH (reduced nicotinamide adenine dinucleotide I) assistance, further fabricated high-resolution multicolor immunosensor for visual detection HER2 ECD by using signal...

10.1021/acs.analchem.9b04828 article EN Analytical Chemistry 2019-12-02

It is crucial that simple and high-throughput methods for determining multiple, or groups of, sulfonamides (SAs) be developed since they are widely used in animal husbandry aquaculture. We a paper-based multicolor colorimetric aptasensor to detect 3 SAs: sulfaquinoxaline (SQ), sulfamethoxypyridazine (SMP) sulfamethoxydiazine (SMD). Using broad-specificity aptamer as bioreceptor, we reduced the growth of nicotinamide adenine dinucleotide I (NADH)–ascorbic acid (AA)-mediated gold...

10.3390/chemosensors11070386 article EN cc-by Chemosensors 2023-07-09

ABSTRACT The enzyme-linked immunosorbent assay (ELISA) is a basic technique used in analytical and clinical investigations. However, conventional ELISA still not sensitive enough to detect ultra-low concentrations of biomarkers for the early diagnosis cancer, cardiovascular risk, neurological disorders, infectious diseases. Herein we show mechanism utilizing CRISPR/Cas13a-based signal export amplification strategy, which double-amplifies output by T7 RNA polymerase transcription...

10.1101/781237 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2019-09-24

Objective To evaluate the clinical performance of INNOVANCE D-Dimer,and provide information for application. Methods 402 cases sodium citrate anticoagulant blood were tested with assay and PLUS on CA7000 analyzer to measure plasma DDimer levels.VIDAS-30 immunology was also used validate two assays.4 patients elevated D-Dimer monitored continuously during 5 days using respectively,then consistency trend between 2 assays analyzed.Plasma specimens added hemoglobin,bilirubin triglyceride...

10.3760/cma.j.issn.1009-9158.2013.07.016 article EN Zhonghua jianyan yixue zazhi 2013-07-11

Objective To investigate the virulence gene and mutation features in Chinese patients with autosomal dominant noctumal frontal lobe epilepsy(ADNFLE) by using direct sequencing(DS) PCR products all exons of CHRNA4 6 ADNFLE families, to interpret molecular pathogenesis affected ADNFLE. Methods Six families were collected, included 66 people 24 ADNFLE, 200 healthy volunteers selected as control group.The genomic DNA was extracted.The 1-6 amplified PCR.The sequenced analyzed.All data...

10.3760/cma.j.issn.2095-428x.2013.12.006 article EN Zhonghua shiyong erke linchuang zazhi 2013-06-20

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Effects of pH and Salt Concentration on the Formation Properties Chitosan–Cellulose Nanocrystal Polyelectrolyte–Macroion ComplexesHezhong Wang, Chen Qian, Maren Roman*Cite this: Biomacromolecules 2012, 13, 4, 1231Publication Date (Web):March 16, 2012Publication History Published online16 March 2012Published inissue 9 April 2012https://doi.org/10.1021/bm300322yCopyright © 2012...

10.1021/bm300322y article EN Biomacromolecules 2012-03-16
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