A5000218377- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Axon Guidance and Neuronal Signaling
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Apelin-related biomedical research
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- UAV Applications and Optimization
- Organ Transplantation Techniques and Outcomes
- Cytokine Signaling Pathways and Interactions
- Biosimilars and Bioanalytical Methods
- Advanced Wireless Communication Technologies
- Angiogenesis and VEGF in Cancer
- Electrochemical sensors and biosensors
- Enzyme Catalysis and Immobilization
- Energy Harvesting in Wireless Networks
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Hydrogen's biological and therapeutic effects
- Fungal Biology and Applications
- Forest, Soil, and Plant Ecology in China
- Biological and pharmacological studies of plants
Nanjing University
2014-2024
Shanxi Agricultural University
2024
Henan Agricultural University
2023-2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2021-2024
Jinyintan Hospital
2024
China Pharmaceutical University
2023
Xidian University
2022-2023
Anshan Hospital
2020-2021
Wenzhou University
2021
Basigin, which has four isoforms, plays an important role in invasion of hepatocellular carcinoma (HCC). Detailed transcriptional regulation and functions the basigin isoforms have not been reported except case predominant isoform basigin-2, act as inducer matrix metalloproteinases (MMPs). Here we determined that basigin-3, basigin-4 were most abundant transcript variants human cell lines. GeneRacer PCR luciferase reporter assays showed basigin-3 initiated from alternative promoter....
This study aims to profile dysregulated microRNA (miRNA) expression in clear cell renal carcinoma (ccRCC) and identify key regulatory miRNAs ccRCC.miRNA profiles nine pairs of ccRCC tumor samples at three different stages the adjacent, non-tumorous tissues were investigated using miRNA arrays. Eleven identified be commonly dysregulated, including up-regulated (miR-487a, miR-491-3p miR-452) eight down-regulated (miR-125b, miR-142-3p, miR-199a-5p, miR-22, miR-299-3p, miR-29a, miR-429,...
Dexamethasone (DEX) is used to treat ocular surface diseases. However, regulating DEX duration in tears while preventing its absorption into the anterior chamber critical for balancing therapy effects and side effects. In this study, a novel magnetic nanoparticle (MNP)-micelle (MC) co-delivery system (MMDS) was developed. The MC moiety MMDS served as carrier MNP part endowed with magnetic-responsive properties. To extend residency, magnetically attracted by an external magnet after...
ω‑3 fatty acids have potential anticancer effects, and consuming food rich in reduces the human renal cell carcinoma (RCC) risk. However, direct effect of on RCC vitro is unknown. In present study, effects α‑linolenic acid (ALA), an acid, were observed proliferation line OS‑RC‑2. The activity gene expression levels peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) cyclooxygenase‑2 (COX‑2) OS‑RC‑2 cells measured by ELISA real‑time RT‑PCR, respectively, following ALA treatment. (20‑80 µM)...
Transforming growth factor-beta (TGF-beta) is a potent immunosuppressor that has been associated with tumor evasion from the host immune surveillance and, thus, progression. We tested novel immunotherapy for human renal cell cancer (RCC) using technique involves adoptive transfer of autologous tumor-reactive, TGF-beta-insensitive CD8(+) T cells into RCC-challenged immunodeficient mice to identify its antitumor responses.The present study was conducted one-to-one strategy treat tumor-bearing...
In this paper, the research work of torque model in plate rolling process, with biting impact considered, is carried out based on mechanical dynamics and process technology. The five-degree-of-freedom dynamic was established for main drive system actual heavy mill, considering clearance between parts. peak torques under different conditions were calculated. influence time steady-state analyzed: decreases increasing, increases increasing. calculation parameters. improved by rebuilding level...
Lubricating oil deterioration in operating machinery is a complicated and dynamic process with combined effects of working conditions, contaminations wear which makes the unpredictable whole life-span cycle, deteriorated lubricating may increase rate cause severe afterwards. On-line monitoring provides only solution to evaluate overall variation conditions by supplying real-time data. Focusing on this issue, paper presents an investigation on-line multi-object system. Three indexes,...
Abstract A new method for the efficient conversion of pyridine methanols and ethyl carboxylates to esters in air catalyzed by Novozym 435 (N435) was reported. The enzyme transesterification reaction performed under optimum conditions: N435 (60 mg) as a biocatalyst, acetonitrile (2.5 mL) solvent, molar ratio (0.2 mmol) carboxylats (1.0 1 : 5, molecular sieve 3 1.00 g, temperature 50 °C, revolution speed 150 rpm time 36 h. still retained yield 80 % after repeated use 10 times. Under optimal...
This work studies optimal solar charging for solar-powered self-sustainable UAV communication networks, considering the day-scale time-variability of radiation and user service demand. The objective is to optimally trade off between coverage performance net energy loss network by proactively assigning UAVs serve, charge, or land. Specifically, studied problem first formulated into a time-coupled mixed-integer non-convex optimization problem, further decoupled two sub-problems tractability....
BACKGROUND: Spindle and kinetochore-associated protein 1 (SKA1) is a component of SKA, which essential for proper chromosome segregation. Recently, SKA1 was found to be over-expressed in several types human cancers. However, reports on the relationship between expression prognosi s bladder cancer, particular, are lacking. OBJECTIVES: To clarify clinical significance as prognostic biomarker early recurrence progression patients with non-muscle invasive cancer (NMIBC). METHODS: The...
Objective: To investigate the long-term effect of triple organ transplantation (liver, kidney, and pancreas) in a patient with end-stage liver disease, post chronic hepatitis B, cirrhosis, renal failure, insulin-dependent diabetes mellitus caused by pancreatitis to explore optimal surgical procedure. Case: A 43-year-old man progressive emaciation hypourocrinia for 2 months. Results indicated exocrine pancreatic insufficiency related (CP) after developing hepatic failure. Simultaneous...
This paper mainly focuses on the development of disaster social work in Mainland China and intervention relief. Before Wenchuan earthquake initial stage post-earthquake, was based individual psychotherapy; from to year 2012 which post-earthquake recovery reconstruction completed, relief began emphasise community building integration, while basic framework for also established. Social workers begin explore new mode developmental localised work. By combining with practical experiences work,...
Abstract Background The CD105+ cell clones isolated from renal carcinoma (RCC)were characterized as cancer stem cells. This study aimed to explore the antitumor mechanism of transform growth factor-β(TGF-β) insensitive CD8+ T cells against in vitro and vivo. Methods were primary RCC lines by immunofluorescence, qRT-PCR western-blotting analysis. expression levels TGF-β1 examined 105 tissues correlation regression analysis performed. tumor specific TGF-beta expanded ex vivo previously...