A5074548953- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Photodynamic Therapy Research Studies
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Cancer, Hypoxia, and Metabolism
- Sulfur Compounds in Biology
- Advanced Drug Delivery Systems
- MXene and MAX Phase Materials
- Diabetic Foot Ulcer Assessment and Management
- Immune cells in cancer
- Metal complexes synthesis and properties
- Antimicrobial agents and applications
- Supramolecular Self-Assembly in Materials
- Silk-based biomaterials and applications
Wenzhou Medical University
2017-2025
University of Chinese Academy of Sciences
2019-2025
Affiliated Eye Hospital of Wenzhou Medical College
2019-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2022-2024
Wenzhou Institute of Technology Testing & Calibration
2024
Zhejiang Lab
2021-2023
Chinese Academy of Sciences
2017-2023
Wenzhou University
2018-2023
State Key Laboratory of Ophthalmology
2023
Switch
2022
M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds can fail the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise clinical practice of wound healing. However, current hydrogels always needed for complex interventions high-cost treatments, such as cytokines cell therapies. In this study, a novel glycyrrhizic acid (GA)-based hybrid dressing intrinsic properties is developed to promote rapid This...
Polydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in antibacterial therapy due to their ease of synthesis, good biodegradability, long-term safety, and excellent photostability. However, the therapeutic effects PDA are generally limited by low conversion efficiency (PCE). Herein, PDA@Ag synthesized via growing Ag on surface then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits high PCE (38.2%),...
Most commonly used wound dressings have severe problems, such as an inability to adapt shape or a lack of antibacterial capacity, affecting their ability meet the requirements clinical applications. Here, nanocomposite hydrogel (XKP) is developed by introducing polydopamine nanoparticles (PDA NPs) into food gum matrix (XK, consisting xanthan and konjac glucomannan, both FDA-approved thickening agents) for skin healing. In this system, embedded PDA NPs not only interact with form excellent...
Polysaccharide hydrogels are widely used in tissue engineering because of their superior biocompatibility and low immunogenicity. However, many these unrealistic for practical applications as the cost raw materials is high, fabrication steps tedious. This study focuses on facile optimization agarose-polydopamine hydrogel (APG) scaffolds skin wound healing. The first objective was to evaluate effects polydopamine (PDA) mechanical properties, water holding capacity cell adhesiveness APG. We...
Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study...
Combination therapy shows great promise in circumventing cisplatin resistance. We report herein the development of a novel nanoscale drug delivery system (nDDS) based nanotherapeutic that combines chemotherapy and photodynamic (PDT) into one single platform to achieve synergistic anticancer capacity conquer Mesoporous silica nanoparticle (MSNs) was used as vector conjugate prodrug load photosensitizer chlorin e6 (Ce6) afford dual loaded MSNs/Ce6/Pt. The hybrid nanoparticles have an average...
Abstract Pathogenic bacteria infection is a serious threat to human public health due the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option improve efficiency compared conventional therapeutic agents. In addition drug loading capacity of nanocarriers, which typically around 10%, further lowers dose that pathological are exposed to. Moreover, nanocarriers not eliminated from body may cause side effects. These limitations have...
Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead the development of chronic diseases. Biocompatible hydrogel antioxidants composed natural materials, such as polysaccharides and polyphenols, are significant option for ROS scavenging. However, rapidly achieving with convenient, economical, safe, efficient features remains challenging. Herein, facile synthesis a physically cross-linked polyphenol/polysaccharide by introducing tannic...
Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano‐sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining application SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich vacancies developed interlayer gaps trioxide nanobelts expanded. Owing to increased vacancy density wide gap‐induced narrower band gap...
Photodynamic therapy (PDT) is a promising strategy for cancer treatment. It can not only generate reactive oxygen species (ROS) to cause the chemical damage of tumor cells in presence enough but also promote antitumor immunity T through enhancing production interferon γ (IFN-γ). However, one phenomenon ignored so far that enhanced IFN-γ caused by PDT may significantly increase expression programmed death-ligand 1 (PD-L1) on cell membrane and thus could inhibit immune killing effects cells....
Polydopamine nanoparticles (PDA NPs) are an appealing biomimetic photothermal agent for antibacterial treatment because of their long-term safety, excellent photostability, accessible manufacturing, and good biodegradability. However, the low conversion efficiency (PCE) PDA NPs requires high-power near-infrared light irradiation, which severely restricts practical application. In this work, PDA@Cu were fabricated by growing Cu in situ on surface then introduced into a polyelectrolyte...
Currently, the role of lysosome, endoplasmic reticulum, or dictyosome in transcription and translation programmed cell death ligand 1 (PD-L1) is well revealed, but function mitochondria PD-L1 expression tumors still not fully researched, making it hard to offer a novel regulation strategy. In this research, newly revealed that oxidative phosphorylation (OXPHOS) depression can be used as an effective down-regulation method. To ideal high-effective tumor mitochondria-targeted OXPHOS...