A5040592630- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Electrospun Nanofibers in Biomedical Applications
- Pressure Ulcer Prevention and Management
- Nanoplatforms for cancer theranostics
- Advancements in Transdermal Drug Delivery
- Corneal Surgery and Treatments
- Laser Applications in Dentistry and Medicine
- Antimicrobial agents and applications
- Planarian Biology and Electrostimulation
- Mesenchymal stem cell research
- Silk-based biomaterials and applications
- Advanced Drug Delivery Systems
- Luminescence and Fluorescent Materials
- Antimicrobial Peptides and Activities
- Advanced Photocatalysis Techniques
- Spinal Cord Injury Research
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Surgical Sutures and Adhesives
Wenzhou Medical University
2021-2024
University of Chinese Academy of Sciences
2024
Affiliated Eye Hospital of Wenzhou Medical College
2023
Polydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in antibacterial therapy due to their ease of synthesis, good biodegradability, long-term safety, and excellent photostability. However, the therapeutic effects PDA are generally limited by low conversion efficiency (PCE). Herein, PDA@Ag synthesized via growing Ag on surface then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits high PCE (38.2%),...
Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study...
Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead the development of chronic diseases. Biocompatible hydrogel antioxidants composed natural materials, such as polysaccharides and polyphenols, are significant option for ROS scavenging. However, rapidly achieving with convenient, economical, safe, efficient features remains challenging. Herein, facile synthesis a physically cross-linked polyphenol/polysaccharide by introducing tannic...
Polydopamine nanoparticles (PDA NPs) are an appealing biomimetic photothermal agent for antibacterial treatment because of their long-term safety, excellent photostability, accessible manufacturing, and good biodegradability. However, the low conversion efficiency (PCE) PDA NPs requires high-power near-infrared light irradiation, which severely restricts practical application. In this work, PDA@Cu were fabricated by growing Cu in situ on surface then introduced into a polyelectrolyte...
Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at...
Current diabetic wound treatments remain difficult in clinical due to bacterial infection and excessive reactive oxygen species (ROS). An ideal dressing should have prominent antibacterial ROS scavenging abilities. In this work, a conveniently multifunctional hydrogel (abbreviated as CuTA/SG) was constructed by incorporating copper/tannic acid nanosheets into dynamic cross-linking network composed of oxidized sodium alginate, gelatin, Ca2+. The resulting CuTA/SG had excellent exudate...
Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel...
Oral ulcers can be managed using a variety of biomaterials that deliver drugs or cytokines. However, many patients experience minimal benefits from certain medical treatments because poor compliance, short retention times in the oral cavity, and inadequate drug efficacy. Herein, we present novel hydrogel patch (SCE2) composed biopolymer matrix (featuring ultraviolet-triggered adhesion properties) loaded with cuttlefish ink nanoparticles (possessing pro-healing functions). Applying...
Bacterial infection can impede the healing of chronic wounds, particularly diabetic wounds. The high-sugar environment wounds creates a favorable condition for bacterial growth, posing challenge to wound healing. In clinical treatment, irregular shape and poor mechanical properties traditional gel adjuvants make them susceptible shear compression, leading morphological changes fractures, difficult adapt Traditional are prepared in advance, while situ is formed at site administration after...