A5013509736- Phytoestrogen effects and research
- Adipokines, Inflammation, and Metabolic Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Saffron Plant Research Studies
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Biological Research and Disease Studies
- Immune cells in cancer
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- Kruppel-like factors research
- Hedgehog Signaling Pathway Studies
- Flavonoids in Medical Research
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
Tianjin Medical University
2024-2025
Eastern Hepatobiliary Surgery Hospital
2022-2023
Second Military Medical University
2021-2023
Shanghai Cancer Institute
2020
Xiamen University
2017
Sichuan University
2008
Introduction Cholangiocarcinoma (CCA) is a malignant tumor of the biliary epithelium with poor prognosis. The lack biomarkers to predict therapeutic response and prognosis one major challenges for CCA treatment. Tertiary lymphoid structures (TLS) provide local pivotal microenvironment immune responses. prognostic value clinical relevance TLS in remain unclear. We aimed explore characteristics significance CCA. Methods investigated using surgery cohort containing 471 patients (cohort 1) an...
Gemcitabine is a nucleoside analog that has been successfully used in the treatment of multiple cancers. However, intrinsic or acquired resistance reduces chemotherapeutic potential gemcitabine. Here, we revealed previously unappreciated mechanism by which phosphatase and tensin homolog (PTEN), one most frequently mutated genes human cancers, dominates decision-making process central to regulation gemcitabine efficacy cholangiocarcinoma (CCA). By investigating gemcitabine-treated CCA cohort,...
The effects of soy isoflavone (SIF) on insulin sensitivity and adipocytokines in high-fat-diet-induced resistant (IR) rats were studied. Male Sprague Dawley (n = 80) randomly assigned into a basal diet fed group high-fat group. IR model control three SIF-treated groups with different dosages. Thirty days later, the fasting blood glucose, serum mRNA expressions perirenal white adipose tissue measured. Homeostasis Model Assessment was calculated. administration 450 mg kg(-1) d(-1) SIF...
Abstract NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles oxidation, promotes degradation in unstressed conditions. SQSTM1/p62, an oncogenic aberrantly accumulated hepatocellular carcinoma (HCC), binds sequestrates Keap1, leading to prevention degradation. Here, we show that p15INK4b-related sequence/regulation nuclear pre-mRNA domain-containing 1A (RPRD1A) highly expressed HCC tumors...
The effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate influence ARM with aim identifying novel targets and developing strategies reduce chemoresistance. Bioinformatics analysis explore ARM‑associated mechanisms contributing treated EOC cells, primarily OVCAR3 human adipose tissue extracts (HATES) from peritumoral...
ABSTRACT Thrombin has been shown to play a key role in lung diseases such as pulmonary fibrosis via the induction of fibrotic cytokine‐ chemokine (CC motif) ligand‐2 (CCL2) expression. We previously reported that transcription factor nuclear factor‐κB (NF‐κB) is responsible for thrombin‐induced CCL2 expression human fibroblasts (HLFs). Here, we extended our study investigate epigenetic regulation mechanism HLFs. HLFs were cultured F‐12 medium. protein and mRNA levels detected by ELISA...
Abstract Cholangiocarcinoma (CCA) is an epithelial malignancy with a dismal prognosis owing to limited treatment options. Here, we identified several compound candidates against CCA using high-throughput drug screen approved or emerging oncology drugs, among which kinesin spindle protein (KSP) inhibitors showed potent cytotoxic effects on cells. Treatment KSP SB743921 and ARRY520 caused significant tumor suppression in xenograft models vivo. Mechanistically, led the formation of abnormal...
The liver is the central organ for digestion and detoxification has unique metabolic regenerative capacities. hepatobiliary system originates from foregut endoderm, in which cells undergo multiple events of cell proliferation, migration, differentiation to form parenchyma ductal under hierarchical regulation transcription factors. Studies on development diseases have revealed that SRY-related high-mobility group box 9 (SOX9) plays an important role embryogenesis progression diseases. SOX9...
Hepatocellular carcinoma (HCC) is the sixth incidence of cancer and third leading cause mortality in world. Facing ever-increasing population HCC patients, there still an urgent need to find good diagnostic prognostic markers explore new therapeutic targets. Phosphotriesterase-related (PTER) protein, expressed protein liver injured or ploycystic kidneys, was reported be correlated with serum aspartate aminotransferase (AST) alanine transaminase (ALT). Our study aimed investigate expression...
Abstract Tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) has only limited clinical benefit and reaches a bottleneck due to its drug resistance. Here, through whole transcriptome sequencing (RNA-Seq) lipidomic analysis, we uncover that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5 interactor (URI) endows HCC with resistance TKIs-induced ferroptosis. Mechanistically, URI directly interacts TRIM28 promotes p53...
Objective To investigate the protective effect of crocin on oxidative stress cell model PC12 and PI3K/Akt signal pathway, as well further explore mechanism cells. Methods Cells were divided into control group, group VE group. The survival rate was detected by MTT method, expression mRNA protein RT-PCR Western blot. Results With concentration in 0.625 μM 5 μM, increased a dose-dependent manner. average optical density PI3K Akt 0.435±0.044 0.375±0.034, 0.378±0.038 0.386±0.043...